The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA948047(CAPZA3 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
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F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.
基因功能參考文獻:
Capping protein alpha3 may play a physiologically important role in sperm architecture as well as in fertility of the human male. PMID: 12029070
蛋白家族:
F-actin-capping protein alpha subunit family
組織特異性:
Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region.