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  4. Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein (EBNA-LP), partial

Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein (EBNA-LP), partial

  • 中文名稱：
    Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein(EBNA-LP) ,partial,Yeast
  • 貨號：
    CSB-YP805852EFA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein(EBNA-LP) ,partial,Yeast
  • 貨號：
    CSB-EP805852EFA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein(EBNA-LP) ,partial,Yeast
  • 貨號：
    CSB-EP805852EFA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein(EBNA-LP) ,partial,Yeast
  • 貨號：
    CSB-BP805852EFA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen leader protein(EBNA-LP) ,partial,Yeast
  • 貨號：
    CSB-MP805852EFA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EBNA-LP
  • Uniprot No.：
  • 別名：
    EBNA-LP; EBNA5Epstein-Barr nuclear antigen leader protein; EBNA-LP; EBV nuclear antigen leader protein; Epstein-Barr nuclear antigen 5; EBNA-5; EBV nuclear antigen 5
  • 種屬：
    Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in the establishment of B-cell immortalization by acting as an EBNA2 coactivator. This transcriptional activation preferentially enhances the expression of the major viral protein LMP1. The interaction between EBNA-LP and host SP100 correlates with coactivation of EBNA2 and the relocalization of SP100 from PML nuclear bodies into nucleoplasm.
  • 基因功能參考文獻：
    1. EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral genome, to enable transcription of virus latency genes. Additionally, EBNA-LP is essential for the survival of EBV-infected naive B cells. PMID: 29462212
    2. EBNALP can modulate the activity of the key transcription activator EP300, an acetyltransferase that activates a broad range of transcription factors. PMID: 29467311
    3. the crystal structure of the nuclear import adaptor importin-alpha1 bound to the nuclear localization signal (NLS) of EBNA-LP that shows EBNA-LP residues 44-RRVRRR-49 binding to the major NLS-binding site at the P0-P5 positions. PMID: 28383161
    4. EBNA2 and EBNA-LP contribute to EBV-mediated B-cell growth transformation. [review] PMID: 26428371
    5. Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2. PMID: 24167291
    6. data strongly support a model in which EBNA2 association with NCoR-deficient RBPJ enhances transcription and EBNALP dismisses NCoR and RBPJ repressive complexes from enhancers PMID: 21518914
    7. Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4. PMID: 17159145
    8. Nuclear-cytoplasmic shuttling is not required for efficient EBNA-LP coactivation function. PMID: 19403674

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  • 亞細(xì)胞定位：
    Host nucleus.
  • 蛋白家族：
    Lymphocryptovirus EBNA-LP family
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:3783746