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  4. Recombinant Human Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK1), partial

Recombinant Human Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK1), partial

  • 中文名稱：
    人PPP4R3A重組蛋白
  • 貨號：
    CSB-YP757098HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PPP4R3A重組蛋白
  • 貨號：
    CSB-EP757098HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PPP4R3A重組蛋白
  • 貨號：
    CSB-EP757098HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PPP4R3A重組蛋白
  • 貨號：
    CSB-BP757098HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PPP4R3A重組蛋白
  • 貨號：
    CSB-MP757098HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FLFL1; KIAA2010; MEK1 SUPPRESSOR 1; MSTP033; P4R3A_HUMAN; PP4R3 ALPHA; PP4R3; PP4R3A; PPP4R3A; Protein phosphatase 4 regulatory subunit 3A; PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA; Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1; SMEK homolog 1, suppressor of mek1 (Dictyostelium); smek1; Smk 1; SMK1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair.
  • 基因功能參考文獻：
    1. A variant in PPP4R3A was associated with reduced metabolic decline in Alzheimer's disease patients. PMID: 29130521
    2. sMEK1 significantly inhibited BMI-1-stimulated oncogenesis. PMID: 27878292
    3. Loss of sMEK1 is associated with Ovarian Neoplasms. PMID: 26378810
    4. The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. PMID: 22349239
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
  • 蛋白家族：
    SMEK family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20219

    OMIM: 610351

    KEGG: hsa:55671

    STRING: 9606.ENSP00000337125

    UniGene: Hs.533887