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AKT2

AKT2,即蛋白激酶Bβ,是一種在細(xì)胞內(nèi)信號(hào)傳導(dǎo)中發(fā)揮重要作用的絲氨酸/蘇氨酸激酶。AKT2主要在胰島素敏感的組織如骨骼肌、脂肪和肝臟中表達(dá),是PI3K/AKT信號(hào)通路的關(guān)鍵組成部分。其作用機(jī)制涉及PI3K產(chǎn)生的PIP3,該物質(zhì)能夠招募AKT2至細(xì)胞膜,并通過磷酸化激活A(yù)KT2。激活后的AKT2能夠磷酸化多種底物,包括FOXO轉(zhuǎn)錄因子、mTOR復(fù)合體等,從而調(diào)控細(xì)胞的生長、代謝、存活和凋亡。AKT2參與的信號(hào)通路包括胰島素信號(hào)通路、IGF-1信號(hào)通路等,這些通路在調(diào)節(jié)細(xì)胞對(duì)營養(yǎng)物質(zhì)的吸收、利用以及能量平衡中起著核心作用。AKT2還與細(xì)胞周期的調(diào)控、細(xì)胞應(yīng)激反應(yīng)和細(xì)胞遷移等過程密切相關(guān)。在生物學(xué)意義上,AKT2對(duì)于維持細(xì)胞的正常生理功能和代謝平衡至關(guān)重要。其異常激活與2型糖尿病、肥胖和某些類型的癌癥等代謝性疾病和腫瘤的發(fā)生發(fā)展有關(guān),是這些疾病治療中的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Mouse RAC-beta serine/threonine-protein kinase (Akt2) (CSB-EP717138MO)

驗(yàn)證數(shù)據(jù)

CSB-EP717138MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AKT2 Antibody (CSB-PA15919A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA15919A0Rb

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat liver tissue
All lanes: AKT2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 52 kDa
Observed band size: 56 kDa

CSB-PA15919A0Rb

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA15919A0Rb at dilution of 1:100

CSB-PA15919A0Rb

Immunofluorescence staining of A549 cells with CSB-PA15919A0Rb at 1:466, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

AKT2 Antibodies

AKT2 for Homo sapiens (Human)

AKT2 Proteins

AKT2 Proteins for Homo sapiens (Human)

AKT2 Proteins for Rattus norvegicus (Rat)

AKT2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

AKT2 Proteins for Mus musculus (Mouse)