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免疫檢查點(diǎn)

Immune Checkpoints

免疫檢查點(diǎn)是免疫激活的調(diào)控因子，主要在免疫應(yīng)答過程中調(diào)節(jié)T細(xì)胞受體（TCR）的抗原識別。它們在維持免疫穩(wěn)態(tài)和預(yù)防自身免疫方面至關(guān)重要。根據(jù)不同的免疫激活作用，免疫檢查點(diǎn)可分為兩種類型：共刺激免疫檢查點(diǎn)和共抑制免疫檢查點(diǎn)。共刺激免疫檢查點(diǎn)是指一系列可以進(jìn)一步刺激免疫反應(yīng)的免疫檢查點(diǎn)，如CD28，ICOS和CD137。相反，共抑制免疫檢查點(diǎn)對抑制免疫反應(yīng)的免疫檢查點(diǎn)，如PD1，CTLA-4和VISTA。在有效的抗腫瘤免疫過程中，T細(xì)胞作為核心的執(zhí)行者，首先被T細(xì)胞受體介導(dǎo)的抗原識別信號激活，同時(shí)眾多的共刺激信號和共抑制信號精細(xì)調(diào)節(jié)T細(xì)胞反應(yīng)的強(qiáng)度和質(zhì)量。在生理情況下，共刺激分子與免疫檢查點(diǎn)分子保持平衡，從而最大程度減少對于周圍正常組織的損傷，維持對自身組織的耐受、避免自身免疫反應(yīng)。而腫瘤細(xì)胞可以通過此機(jī)制，異常上調(diào)共抑制分子及其相關(guān)配體，抑制T細(xì)胞激活，從而逃避免疫殺傷。

免疫檢查點(diǎn)產(chǎn)品

近幾年， CUSABIO研發(fā)團(tuán)隊(duì)致力于靶向免疫研究，為廣大科研用戶開發(fā)了一系列免疫檢查點(diǎn)重組蛋白。這些重組免疫檢查點(diǎn)蛋白涵蓋多種物種和標(biāo)簽，秉承客戶至上的原則，所有蛋白產(chǎn)品在發(fā)貨前我們都會對其生物活性進(jìn)行再次分析和驗(yàn)證。另外，我們還提供蛋白質(zhì)定制服務(wù)，如果您找不到您需要的蛋白質(zhì)，請聯(lián)系我們進(jìn)行定制服務(wù)。

產(chǎn)品名稱 貨號 規(guī)格
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) CSB-AP005131HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) CSB-AP005141HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) CSB-AP005151HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005171HU 1mg(1mg*1 or 500ug*2)/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human CD160 antigen (CD160) (Active) CSB-AP005221HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active) CSB-AP005241HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active) CSB-AP005251HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active) CSB-AP005261HU 1mg(1mg*1 or 500ug*2)/500μg/50μg/10μg
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active) CSB-AP005271HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005281HU 100ug/20ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005291HU 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug
Recombinant Mouse Tumor necrosis factor receptor superfamily member 14 (Tnfrsf14), partial (Active) CSB-AP005311MO 1mg(1mg*1 or 500ug*2)/500ug/50ug/10ug