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BCL2

BCL2,即B細(xì)胞淋巴瘤/白血病-2基因,別名包括Bcl-2家族中的抗凋亡蛋白,如Bcl-2、Bcl-XL、Bcl-W、Mcl-1等。它最初在血液淋巴細(xì)胞中被發(fā)現(xiàn),能夠顯著抑制細(xì)胞死亡。BCL2基因的作用機(jī)制復(fù)雜,主要通過(guò)調(diào)控線粒體途徑來(lái)抑制細(xì)胞凋亡,它能夠阻止細(xì)胞色素c的釋放,抑制活化的Caspases對(duì)線粒體的影響,從而維持細(xì)胞生存。此外,BCL2還能通過(guò)抗氧化作用、抑制鈣離子跨膜流動(dòng)和調(diào)節(jié)離子通道蛋白功能等多種機(jī)制來(lái)發(fā)揮作用。BCL2在細(xì)胞凋亡的信號(hào)通路中扮演著關(guān)鍵角色,它通過(guò)與Bax等促凋亡蛋白相互作用,形成二聚體,調(diào)節(jié)線粒體膜的通透性,進(jìn)而影響細(xì)胞色素c的釋放和Caspase級(jí)聯(lián)反應(yīng)的激活。BCL2的生物學(xué)意義重大,它不僅在細(xì)胞存活和凋亡的平衡中發(fā)揮作用,還與多種疾病的發(fā)生發(fā)展密切相關(guān),包括癌癥、神經(jīng)退行性疾病等。BCL2的功能失調(diào)可能導(dǎo)致細(xì)胞凋亡途徑的異常激活,影響細(xì)胞的正常生理功能。

熱銷(xiāo)產(chǎn)品

Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) (CSB-CF002611RA)

驗(yàn)證數(shù)據(jù)

CSB-CF002611RA

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BCL2 Recombinant Monoclonal Antibody (CSB-RA564360A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA564360A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U-937 whole cell lysate, THP-1 whole cell lysate, Raji whole cell lysate, Mouse Spleen whole cell lysate
All lanes: Bcl-2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27, 23 kDa
Observed band size: 27 kDa

CSB-RA564360A0HU

IHC image of CSB-RA564360A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit (CSB-E08854r)

驗(yàn)證數(shù)據(jù)

CSB-E08854r 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E08854r

規(guī)格:96T/48T

靈敏度:0.078 ng/mL

檢測(cè)范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BCL2 Antibodies

BCL2 for Mus musculus (Mouse)

BCL2 for Homo sapiens (Human)

BCL2 for H, M, R

BCL2 Proteins

BCL2 Proteins for Gallus gallus (Chicken)

BCL2 Proteins for Homo sapiens (Human)

BCL2 Proteins for Mus musculus (Mouse)

BCL2 Proteins for Rattus norvegicus (Rat)

BCL2 Proteins for Bos taurus (Bovine)

BCL2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

BCL2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

BCL2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

BCL2 Proteins for Rattus norvegicus (Rat)

BCL2 ELISA Kit

BCL2 ELISA Kit for Homo sapiens (Human)

BCL2 ELISA Kit for Mus musculus (Mouse)

BCL2 ELISA Kit for Rattus norvegicus (Rat)