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BCL2L1

BCL2L1,即B細(xì)胞淋巴瘤/白血病2樣蛋白1,別名BCL2L01、Bcl-2相關(guān)蛋白A1、Bfl-1等。BCL2L1是一種抗凋亡蛋白,屬于Bcl-2家族成員,由人體細(xì)胞自身的基因編碼。它在細(xì)胞凋亡的調(diào)控中起著重要作用,主要通過與促凋亡蛋白如Bax或Bak相互作用,抑制線粒體介導(dǎo)的凋亡途徑。BCL2L1的作用機制涉及其在細(xì)胞質(zhì)和線粒體之間的動態(tài)分布,以及其對線粒體膜通透性的調(diào)控。BCL2L1在生物學(xué)上的意義非常廣泛,它參與了細(xì)胞對各種應(yīng)激反應(yīng)的適應(yīng),包括氧化應(yīng)激、DNA損傷、細(xì)胞因子誘導(dǎo)的應(yīng)激等。BCL2L1的表達(dá)受多種信號通路的調(diào)控,如p53、NF-κB、MAPK等,這些信號通路在細(xì)胞生存和凋亡的平衡中發(fā)揮關(guān)鍵作用。BCL2L1的功能異常與多種疾病的發(fā)生發(fā)展有關(guān),尤其是與腫瘤的發(fā)生發(fā)展密切相關(guān)。在腫瘤細(xì)胞中,BCL2L1的過表達(dá)有助于腫瘤細(xì)胞逃避免疫監(jiān)視和化療誘導(dǎo)的凋亡,因此,它是腫瘤治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Bcl-2-like protein 1 (BCL2L1), partial (CSB-EP002613HU)

驗證數(shù)據(jù)

CSB-EP002613HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BCL2L1 Recombinant Monoclonal Antibody (CSB-RA247982A0HU)

驗證數(shù)據(jù)

CSB-RA247982A0HU

Western Blot
Positive WB detected in: K562 whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Bcl-XL antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27, 19, 26 kDa
Observed band size: 30 kDa

CSB-RA247982A0HU

IHC image of CSB-RA247982A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Bcl-2-like protein 1(BCL2L1) ELISA kit (CSB-EL002613HU)

驗證數(shù)據(jù)

CSB-EL002613HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL002613HU

規(guī)格:96T/48T

靈敏度:0.156 ng/mL

檢測范圍:0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BCL2L1 Antibodies

BCL2L1 for Homo sapiens (Human)

BCL2L1 Proteins

BCL2L1 Proteins for Rattus norvegicus (Rat)

BCL2L1 Proteins for Sus scrofa (Pig)

BCL2L1 Proteins for Mus musculus (Mouse)

BCL2L1 Proteins for Homo sapiens (Human)

BCL2L1 ELISA Kit

BCL2L1 ELISA Kit for Homo sapiens (Human)

BCL2L1 ELISA Kit for Rattus norvegicus (Rat)