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CD33

CD33又名氨基肽酶N(APN),是一種跨膜糖蛋白,屬于唾液酸結(jié)合免疫球蛋白樣凝集素的一員。CD33在交聯(lián)或者配體結(jié)合后激活,介導(dǎo)抑制信號(hào),調(diào)節(jié)細(xì)胞內(nèi)鈣動(dòng)員、細(xì)胞粘附、白血病細(xì)胞凋亡、髓系細(xì)胞成熟和細(xì)胞因子的產(chǎn)生等等。CD33在90%以上的急性髓系白血病患者都有表達(dá)。在造血干細(xì)胞表面沒(méi)有表達(dá),在成熟的粒細(xì)胞和其他組織也沒(méi)有表達(dá),CD33作為髓系白血病治療的潛力靶點(diǎn),一批企業(yè)相繼布局了CD33藥物的研發(fā),輝瑞的靶向CD33的ADC藥物Mylotarg已獲批上市。除了ADC藥物外,靶向CD33的雙抗藥物和CAR-T細(xì)胞療法亦在如火如荼地研發(fā)中。

Recombinant Human CD33 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.

CD33 Antibodies

CD33 for Homo sapiens (Human)

CD33 Proteins

CD33 Proteins for Homo sapiens (Human)

CD33 Proteins for Mus musculus (Mouse)

CD33 Proteins for Homo sapiens (Human)

CD33 ELISA Kit

CD33 ELISA Kit for Homo sapiens (Human)