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MSLN

Mesothelin:癌癥免疫治療的后起之秀

間皮素(Mesothelin,MSLN)是由MSLN基因編碼的一種細(xì)胞表面糖蛋白。作為一種存在于正常間皮細(xì)胞上的分化抗原,MSLN在正常組織中表達(dá)少,在氣管,卵巢,睪丸,扁桃體和輸卵管的上皮細(xì)胞表面上表達(dá)最低。有研究表明間皮素可能在粘附中發(fā)揮作用。隨著人們對腫瘤中間皮素的研究越來越深入,已經(jīng)發(fā)現(xiàn)它在多種腫瘤的發(fā)生發(fā)展中起著重要作用。MSLN的過表達(dá)可激活NF-κB,MAPK和PI3K通路,并通過誘導(dǎo)MMP7和MMP9的激活和表達(dá)誘導(dǎo)細(xì)胞凋亡或促進(jìn)細(xì)胞增殖,遷移和轉(zhuǎn)移。MSLN已被發(fā)現(xiàn)在高達(dá)幾十種癌癥中異常表達(dá),包括間皮瘤、卵巢癌、肺癌,食道癌,胰腺癌,胃癌,膽管癌,子宮內(nèi)膜癌,胸腺癌,結(jié)腸癌和乳腺癌。目前針對MSLN設(shè)計了各種免疫治療策略,主要包括基于MSLN的抗體療法和CAR-T。迄今報道的MSLN靶向免疫治療具有良好的安全性。因此,MSLN成為了許多常見實體腫瘤中潛在治療靶點。

Recombinant Human MSLN 活性蛋白實驗驗證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.

 

MSLN Antibodies

MSLN for Mus musculus (Mouse)

MSLN for Homo sapiens (Human)

MSLN Proteins

MSLN Proteins for Mus musculus (Mouse)

MSLN Proteins for Rattus norvegicus (Rat)

MSLN Proteins for Homo sapiens (Human)

MSLN ELISA Kit

MSLN ELISA Kit for Homo sapiens (Human)