TNFRSF13C
TNFRSF13C(又稱B-cell-activating factor receptor,BAFF-R)是與BAFF結(jié)合的特異性受體。BAFF-R作為B細(xì)胞譜系表面的標(biāo)志物,在多種B細(xì)胞惡性腫瘤中高度表達(dá),是免疫治療的理想靶點。在機(jī)制上,BAFF-R信號激活NFkB通路,促進(jìn)腫瘤存活和增殖。B細(xì)胞淋巴瘤和急性淋巴細(xì)胞白血?。╝cute lymphoblastic leukaemia,ALL)患者中BAFF-R表達(dá)增加與疾病進(jìn)展相關(guān)。相關(guān)研究報道已表明,BAFF-R信號是B細(xì)胞生長和存活的驅(qū)動因素。這一關(guān)鍵特征提示,可以通過下調(diào)BAFF-R表達(dá)來限制B細(xì)胞腫瘤逃避治療的能力。BAFF/BAFF-R軸已成功地用于自身免疫性疾病,特別是針對BAFF配體的單克隆抗體。最近,靶向BAFF-R的單克隆抗體在臨床前模型中顯示了對慢性淋巴細(xì)胞性白血病(CLL)的療效,尤其是與Bruton酪氨酸激酶抑制劑聯(lián)合使用時,該單克隆抗體已進(jìn)入臨床試驗(NCT03400176)。
Recombinant Human TNFRSF13C 活性蛋白實驗驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 2 μg/ml can bind TNFRSF13C, the EC50 is 9.943-15.72 ng/ml.
TNFRSF13C Antibodies
TNFRSF13C for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA853495LA01HU | TNFRSF13C Antibody | Human | ELISA |
CSB-PA853495LC01HU | TNFRSF13C Antibody, FITC conjugated | Human | |
CSB-PA853495LD01HU | TNFRSF13C Antibody, Biotin conjugated | Human | ELISA |
CSB-PA984896 | TNFRSF13C Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA249091 | TNFRSF13C Antibody | Human,Mouse | ELISA,IHC |
TNFRSF13C Proteins
TNFRSF13C Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP853495HU CSB-EP853495HU CSB-BP853495HU CSB-MP853495HU CSB-EP853495HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP002181HU | Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein (TNFRSF13C), partial (Active) | E.Coli |
CSB-MP853495HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), partial (Active) | Mammalian cell |
TNFRSF13C Proteins for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP884026MO CSB-EP884026MO CSB-BP884026MO CSB-MP884026MO CSB-EP884026MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 13C (Tnfrsf13c), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF13C ELISA Kit
TNFRSF13C ELISA Kit for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL023972MO | Mouse Tumor necrosis factor receptor superfamily member 13C(TNFRSF13C) ELISA kit | serum, plasma, tissue homogenates | 9.75 pg/ml |