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  4. Human Bone morphogenetic protein 8A(BMP8A) ELISA kit

Human Bone morphogenetic protein 8A(BMP8A) ELISA kit

  • 中文名稱：
    人骨形態(tài)發(fā)生蛋白8A(BMP8A)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL002745HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    This Human BMP8A ELISA Kit was designed for the quantitative measurement of Human BMP8A protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 37.5 pg/mL-2400 pg/mL and the sensitivity is 9.38 pg/mL.

  • 別名：
    BMP-8A ELISA Kit; BMP8 ELISA Kit; Bmp8a ELISA Kit; BMP8A_HUMAN ELISA Kit; Bone morphogenetic protein 8A ELISA Kit; FLJ14351 ELISA Kit; FLJ45264 ELISA Kit; OP 2 ELISA Kit; Osteogenic protein 2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    37.5 pg/mL-2400 pg/mL
  • 靈敏度：
    9.38 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Stem Cells
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
  • 基因功能參考文獻：
    1. Authors found that Bmp8a, but not Bmp8b, was expressed predominantly in the neonatal mouse spermatogonia. Although most BMPs induce activation of SMADs 1, 5, and 8 (SMAD1/5/8), but not SMADs 2 and 3 (SMAD2/3), they found that BMP8A induced signaling through both sets of transcription factors. PMID: 28465413
    2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20424473
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21650

    KEGG: hsa:353500

    STRING: 9606.ENSP00000327440

    UniGene: Hs.472497