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  4. Human CXC-chemokine ligand 16,CXCL16 ELISA Kit

Human CXC-chemokine ligand 16,CXCL16 ELISA Kit

  • 中文名稱：
    人CXC趨化因子配體16(CXCL16)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08871h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        趨化因子2（C-X-C motif chemokine ligand 2）是一種由炎癥介導(dǎo)產(chǎn)生的細(xì)胞因子，可以調(diào)節(jié)炎癥和免疫反應(yīng)。它通過(guò)作用于CXCR2受體介導(dǎo)細(xì)胞信號(hào)傳導(dǎo)，參與調(diào)節(jié)中性粒細(xì)胞的趨化和激活。
        華美生物所提供的Human CXC-chemokine ligand 16,CXCL16 ELISA Kit屬于ELISA檢測(cè)試劑盒，采用雙抗夾心法定量檢測(cè)人血清、血漿、組織勻漿樣本中的CXCL16，其靈敏度為3.603 pg/mL，檢測(cè)范圍為46.875 pg/mL-3000 pg/mL。
     
  • 別名：
    C-X-C motif chemokine 16 ELISA Kit; Chemokine (C X C motif) ligand 16 ELISA Kit; Chemokine; CXC motif; ligand 16 ELISA Kit; CXC chemokine ligand 16 ELISA Kit; Cxcl16 ELISA Kit; CXCLG16 ELISA Kit; CXL16_HUMAN ELISA Kit; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein ELISA Kit; SCYB16 ELISA Kit; Small inducible cytokine B16 precursor ELISA Kit; Small-inducible cytokine B16 ELISA Kit; SR-PSOX ELISA Kit; SRPSOX ELISA Kit; Transmembrane chemokine CXCL16 ELISA Kit; UNQ2759/PRO6714 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    46.875 pg/mL-3000 pg/mL
  • 靈敏度：
    3.603 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human CXCL16 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    CXCL16主要參與T細(xì)胞、NK細(xì)胞和巨噬細(xì)胞的趨化作用，同時(shí)也是重要的炎癥介質(zhì)，能促進(jìn)炎癥反應(yīng)的形成和細(xì)胞凋亡。最新研究表明，CXCL16不僅在腫瘤發(fā)生、發(fā)展過(guò)程中發(fā)揮重要作用，而且在神經(jīng)退行性疾病、心血管疾病等方面也有潛在作用。
  • 功能：
    Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
  • 基因功能參考文獻(xiàn)：
    1. demonstrate that macrophages can promote the migration and invasion of ovarian carcinoma cells by affecting the CXCL16/CXCR6 pathway PMID: 30049511
    2. activation of cancer-associated fibroblasts and expression of CXCL16, shown to be a monocyte chemoattractant. PMID: 27725631
    3. Enhanced CXCL16 expression in lung cancer tissue promoted the proliferation and invasion of lung cancer cells. CXCL16 might promote proliferation and invasion of lung cancer by regulating the NF-kappaB pathway. PMID: 29353287
    4. increased plasma sCXCL16 might be implicated in the pathogenesis of immune thrombocytopenia and have a relationship with Th1/Th2 imbalance. PMID: 28886489
    5. Serum CXCL16 levels are significantly increased in patients with gallstone, and are independently associated with liver injury in Chinese population, suggesting that CXCL16 may be a biomarker of liver injury in subjects with gallstone or NAFLD. Hepatic CXCL16 mRNA and protein levels were also significantly increased in gallstone patients PMID: 28722105
    6. IFN-gamma, CXCL16 and uPAR are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in systemic lupus erythematosus. PMID: 28628472
    7. Data showed that reverse signaling via CXCL16 promotes migration in CXCL16-expressing melanoma and glioblastoma cells, but does not affect proliferation or protection from chemically-induced apoptosis. PMID: 28698473
    8. Study showed, for the first time, highly significant relationships of circulating CXCL16 level with cardiac injury markers in dialysis patients. PMID: 28633141
    9. Women with gestational diabetes mellitus and preeclampsia had a dysregulated CXC chemokine ligand 16 during pregnancy, and in gestational diabetes mellitus, the increase in CXC chemokine ligand 16 early in pregnancy and after 5 years was strongly associated with their lipid profile. PMID: 28856928
    10. Data suggest that primary cells from papillary renal cell carcinoma secrete the chemokines IL8, CXCL16, and chemerin; these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 = interleukin-8; CXCL16 = C-X-C motif chemokine ligand 16) PMID: 28759013
    11. Our study demonstrated that CXCL16-CXCR6 mediates CD8(+) T-cell skin trafficking under oxidative stress in patients with vitiligo, and CXCL16 expression in human keratinocytes induced by ROS is, at least in part, caused by unfolded protein response activation PMID: 27826097
    12. eGFR and serum albumin had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease. PMID: 27665581
    13. The expression of CXCL16 and and its receptor, CXCR6, their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines are reported. PMID: 27869573
    14. Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. PMID: 27877078
    15. CXCL16 single nucleotide polymorphisms significantly impacted myocardial infarction risk in a Chinese Han population. PMID: 28286356
    16. Transmembrane-CXCL16 specifically acts as a receptor for soluble-CXCL16 in human meningioma cells. PMID: 27784296
    17. Higher levels CXCL16 may be a biomarker for predicting stroke incidence and might contribute to plaque destabilization. PMID: 27355560
    18. CXCL16 is released into the circulation as a result of cardiac surgery and that high post-operative CXCL16 levels are associated with an increased severity of post-operative organ dysfunctions. PMID: 26499307
    19. Serum CXCL16 may be a novel biomarker for the diagnosis of patients with diabetic coronary artery disease. PMID: 27098626
    20. High CXCL16 expression is associated with prostate cancer. PMID: 26799186
    21. In conclusion, rheumatoid arthritis synovial fibroblasts were activated by CXCL16 to produce RANKL via pathways involving JAK2/STAT3 and p38/MAPK PMID: 26621504
    22. Our data suggest that CXCL16 induces angiogenesis in autocrine manner via ERK, Akt, p38 pathways and HIF-1alpha modulation PMID: 26707275
    23. Cell proliferation enhancing and anti-apoptosis activity requires the intracellular domain and apparently the dimerization of the transmembrane chemokine ligand. PMID: 26796342
    24. Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation. PMID: 26708384
    25. Endothelial CXCL16's action on platelets is not limited to platelet activation. Immobilised CXCL16 also acts as a potent novel platelet adhesion ligand, inducing platelet adhesion to the human vessel wall. PMID: 25904061
    26. HMGB-1, CXCL16, miRNA-30a, and urinary TGF-ss1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS. PMID: 26345917
    27. high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in prostate cancer were independent predictors for a worse clinical outcome PMID: 26272362
    28. PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease PMID: 26045830
    29. These results indicate that MEK inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions. PMID: 26058873
    30. we examined the expression of CXCL16 and CXCR6 and their relations to prognosis in 335 unselected patients with NSCLC, and investigated possible relationships with our previously studied immunologic and angiogenic markers PMID: 26021984
    31. CXCL16 T123V181 haplotype is a moderate genetic risk factor for the development of carotid plaque. PMID: 25142184
    32. Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy PMID: 25661686
    33. injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD. PMID: 25372401
    34. CXCL16 and CXCR6 coexpression is associated with invasiveness of lung cancer. PMID: 24897301
    35. No significant association of the CXCL16 polymorphism was established either with soluble CXCL16 plasma levels or with clinical parameters and course of multiple sclerosis. PMID: 24854635
    36. CXCL16 expression is enhanced in inflammatory cardiomyopathy and is an independent predictor of death in patients with heart failure. PMID: 25223819
    37. Elevated serum sCXCL16 levels were discovered in the systemic lupus erythematosus patients with cutaneous and renal involvement. PMID: 25015061
    38. Silencing CXCL16 could phenocopy the effects of miR-451 on phenotypes of osteosarcoma cells. PMID: 25391425
    39. High circulating CXCL16 levels are associated to human kidney and cardiovascular disease and urinary CXCL16 may increase in kidney injury. PMID: 24861945
    40. Serum CXCL16 may be an indicator of renal injury in subjects with type 2 diabetes mellitus. PMID: 24489966
    41. Serum CXCL16 was increased in patients with active Primary nephrotic syndrome and correlated with blood lipids, urine protein and immune and inflammation responses PMID: 24460887
    42. High serum sCXCL16 is a prognostic marker for poor survival of OC patients, possibly reflecting ADAM-10 and ADAM-17 pro-metastatic activity. PMID: 24518602
    43. CXCL16, iNKT cell-associated cell marker Valpha24, and CD1d were significantly upregulated in esophageal biopsies from EoE patients and correlated with the expression of inflammatory mediators associated with allergy. PMID: 24513807
    44. CXCL16 could be a novel biomarker and potential predictor of disease activity in MS. PMID: 24069377
    45. CXCL16/CXCR6 interaction may play an important role in modifying the response of pDCs to environmental danger signals PMID: 24302814
    46. Our results suggest that the CXCL16/CXCR6 axis appears to be important in the progression of Ewing sarcoma family tumor PMID: 24507753
    47. Data suggest that plasma level of CXCL16 is up-regulated in subjects with metabolic syndrome and correlates with severity of carotid atherosclerosis (i.e., intima-media thickness and plaque index). PMID: 23398954
    48. Erythrocyte adhesion to immobilized platelets requires phosphatidylserine at the erythrocyte surface and CXCL16 as well as CD36 expression on platelets. PMID: 24284794
    49. CXCL16, inversely correlated with CD99 expression in Hodgkin Reed-Sternberg (H/RS) cells. PMID: 23743627
    50. Suggest that expression of transmembrane CXCL16 on surface of plasmacytoid dendritic cell might contribute to high serum IFN-alpha levels seen in patients with Behcet's disease. PMID: 24064021

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 組織特異性：
    Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16642

    OMIM: 605398

    KEGG: hsa:58191

    STRING: 9606.ENSP00000293778

    UniGene: Hs.745037