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Human E-Selectin ELISA kit

  • 中文名稱：
    人E選擇素(E-Selectin/CD62E)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04540h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        SELE (E-選擇素) 是一種跨膜受體蛋白，主要表達于內(nèi)皮細胞表面，能夠介導白細胞的黏附和轉移。SELE 的表達受到多種炎癥介質(zhì)的調(diào)節(jié)，它可以被視為一種炎癥標記物。SELE 的異常表達與多種疾病有關，例如心血管疾病、炎癥性腸病等。
        華美生物所提供的Human E-Selectin ELISA kit屬于ELISA檢測試劑盒，采用雙抗夾心法定量檢測人血清、血漿、組織勻漿樣本中的SELE，其靈敏度為0.078 ng/mL，檢測范圍為0.312 ng/mL-20 ng/mL。
     
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
    SELE是選擇素E的縮寫，是一種黏附分子，可以調(diào)節(jié)白細胞的黏附和遷移，最近的研究表明其在多種疾病的發(fā)生和發(fā)展中具有重要作
  • 功能：
    Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
  • 基因功能參考文獻：
    1. Results highlight novel mechanisms by which p38 downregulates the expression of E-selectin through miR-146a and miR-31 following inflammatory stimuli associated to cancer progression. PMID: 29402939
    2. Levels of E and P selectin showed positive correlation with the length of stay. PMID: 29517629
    3. Our study shows a significant association of E-selectin gene polymorphism(Leu554Phe) with essential hypertension. PMID: 29178542
    4. The highest levels of sL- and sE-selectin were observed in colorectal patients with lymph node metastasis. PMID: 27775438
    5. Circulating CD62E(+) microparticle levels are abnormal in subjects with pre-diabetes. PMID: 28927403
    6. sVCAM-1 reflects xerostomia in primary Sjogren's syndrome. sICAM-1 and sE-selectin may be additional parameters of secondary Sjogren's syndrome activity. PMID: 29068581
    7. Neutrophil rolling over E-selectin at precise shear stress transmits tension and catch-bond formation with L-selectin via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit PMID: 28811304
    8. E-selectin-dependent rolling promotes adhesion to HA by both physically slowing cells and enabling them to position proximal to the surface, thereby increasing the on rate of adhesion. PMID: 28765175
    9. High E-selectin expression is associated with breast cancer metastasis. PMID: 27220365
    10. his study shows that two adhesion molecules, shed as soluble forms, are elevated during the acute phase of leptospirosis: E-selectin and s-ICAM1. These molecules may interfere with the process of immune cell recruitment to clear Leptospira at tissue levels. PMID: 28686648
    11. ELAM-1 upregulation may promote disorder in adhesion, and migration of the cells leading to the endometriosis disorder. PMID: 27433816
    12. Elevated endothelium-related mediators (vWF, E-selectin and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis. PMID: 28007459
    13. interplay between flow-dependent on-rate and off-rate of E-selectin-ligand bonds determine flow-enhanced cell rolling stability PMID: 27558713
    14. High SELE expression is associated with Inflamed Atherosclerotic Plaque. PMID: 27237221
    15. In this study, we addressed this question by analysing sLex expression together with two glycoproteins (BST-2 and LGALS3BP), shown to interact with E-selectin in a carbohydrate-dependent manner, in a cohort of 249 invasive breast cancers PMID: 27176937
    16. SELE expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    17. E-selectin concentrations in this study were associated with hyperglycemia, possibly reflecting early endothelial damage. E-selectin was not useful to assess carotid intima-media thickness, a marker of subclinical atherosclerosis, which appeared to be determined by aging and male gender. PMID: 27141013
    18. Plasma E-selectin is overexpressed in pediatric patients with mycoplasma pneumoniae pneumonia and myocardial injury. PMID: 26843511
    19. The significant presence of CLA+ T cells and E-selectin (CD62E) expressions in the OLPG suggests their involvement in the etiopathogenesis of oral lichen planus ; however, only a weak correlation between CLA+ T cells and E-selectin was observed. PMID: 26332489
    20. BD patients have a lower expression of ICAM-1, VCAM-1, and E-selectin in their tumor tissues. BD-HDL facilitates the adhesion of tumor cells to vascular endothelium by upregulating the expression of ICAM-1 and VCAM-1, thereby promoting the initial progression of breast cancer metastasis PMID: 26872904
    21. The E-selectin S149R polymorphisms is associated with the oncogenesis of breast cancer. PMID: 26828984
    22. Neisseria meningitidis caused a high level of E-selectin expression elicited by the activity of phosphorylated ATF2 transcription factor on the E-selectin promoter. PMID: 26153406
    23. E-selectin is more effective than cTnI in diagnosing myocardial injury in children. PMID: 26617843
    24. Inhibition of E-selectin expression allows an anti-tumoral effect on sLex-expressing hepatocellular carcinoma tumors in vivo PMID: 26988221
    25. Glycosphingolipids likely contribute to human myeloid cell adhesion to E-selectin under fluid shear, particularly the transition of rolling cells to firm arrest. PMID: 26868209
    26. Data show that both mucin16 (MUC16) and podocalyxin (PODXL)-E-selectin-mediated interactions are mechanically stronger than like L-selectin interactions at the single-molecule level. PMID: 26329844
    27. These findings provide consistent evidence that A516C and G98T polymorphisms of the SELE gene may be associated with increased susceptibility of coronary artery disease. PMID: 26937892
    28. Glaucomatous MYOC mutations activate the IL-1beta/NF-kappaB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. PMID: 26396484
    29. P. gingivalis was shown to activate NOD1, NOD2, and TLR2 expression, resulting in increased E-selectin expression in endothelial cells; direct inhibition of NF-kappaB and P38 MAPK significantly attenuated E-selectin expression induced by P. gingivalis in endothelial cells PMID: 25939768
    30. The number of E-selectin-positive cells was significantly higher in the tuberculoid form than in the lepromatous form of leprosy skin lesions. PMID: 26051909
    31. Gene-based study revealed significant associations of the SELE gene with Blood Pressure phenotypes for the first time among the Chinese Han population. PMID: 25424718
    32. This study showed that no significant differences in F206L Polymorphism of l-Selectin Between the Patients with Bronchial Asthma and Control. PMID: 24798295
    33. Blood ESEL was higher in pregnant women with preeclampsia, and non-pregnant women with a history of preeclampsia than women without preeclampsia or a history of preeclampsia. PMID: 26116870
    34. The findings suggest that C allele carriers of the SELE gene polymorphism (A561C) might be predisposed to EH in the Chinese population. PMID: 25171839
    35. E-selectin promoter was highly and specifically acetylated in the confluent monolayer after tumor necrosis factor alpha activation. PMID: 24690766
    36. E-selectin interactions with glycoprotein ligands (CD44/hematopoietic cell E-/L-selectin ligand and PSGL-1) mediate the initial capturing of cells out of flow. PMID: 26124272
    37. SELE rs3917412 and MTHFR rs1801133 SNPs could serve as pharmacogenetic predictors of tumor recurrence in patients with early-stage colon cancer treated with oxaliplatin-based adjuvant chemotherapy PMID: 24980946
    38. sE-selectin and the LDL were the most important predictors of late arteriovenous fistula stenosis PMID: 24627030
    39. The C allele of E-selectin A561C gene polymorphism might increase the essential hypertension (EH) risk in Asian population, whereas the T allele of E-selectin C1839T gene polymorphism might decrease the EH risk. [meta-analysis] PMID: 25003340
    40. Bereaved respondents had higher levels of inflammatory biomarkers IL-6 and sE-selectin, but not CRP and sICAM-I than the non-bereaved. PMID: 24266503
    41. SE-selectin and PAPPA may contribute to future cardiovascular events in women post preeclampsia; in contrast, ApoB may be involved in a protective mechanism PMID: 25238218
    42. the haplotype TCC in the Han hypertensive patients and the haplotype GGC in the Mongolian patients had independent effects in increasing the risk for essential hypertension; multiple single-nucleotide polymorphisms in combination in SELE may confer a risk of hypertension. PMID: 25748737
    43. Found the AC genotype to be a significant risk factor for hemorrhagic stroke and we also found significant differences in AC genotype and C allele among hemorrhagic stroke and ischemic stroke patients. PMID: 25168603
    44. The rs5361 E-selectin gene polymorphism is not a susceptibility marker for ACS in Western Mexico population. However, sE-selectin may be a biological marker of ACS. PMID: 25147432
    45. ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes PMID: 25498912
    46. an upregulation of E-selectin and the associated influx of neutrophils may play a significant role in the resolution of inflammation as well as for the pathophysiology of nasal polyps of Caucasian chronic rhinosinusitis patients. PMID: 24995349
    47. in human aortic and vein endothelial cells, expression and release of ICAM-1 and E-selectin were induced by treatment with conditioned medium collected from Pal-stimulated pTHP-1 cells PMID: 25201247
    48. CD62E was found to be a new biomarker for patients with hypertension and hyperlipidemia. PMID: 24820735
    49. High E-Selectin expression is associated with small cell lung cancer metastasis. PMID: 24699516
    50. there was association between the E-selectin S128R polymorphism and the risk of cancer. PMID: 24815478

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Selectin/LECAM family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10718

    OMIM: 131210

    KEGG: hsa:6401

    STRING: 9606.ENSP00000331736

    UniGene: Hs.82848