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中文名稱:人胎球蛋白B(FETUB)酶聯(lián)免疫試劑盒
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貨號:CSB-EL008598HU
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:
The product CSB-EL008598HU is a sandwich ELISA kit developed to measure levels of human Fetuin-B (FETUB) in multiple samples, including serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of FETUB in samples. The color intensity is measured at 450 nm via a microplate reader.
FETUB is a highly selective and potent inhibitor of metallopeptidases (MPs) of the astacin family. It is a liver-derived plasma protein with serum concentrations of about 0.01 g/l in humans. FETUB plays an essential role in female fertility. By blocking ovastacin, fetuin-B counteracts premature zona pellucida (ZP) hardening before fertilization and therefore maintains female fertility by keeping the ZP penetrable to sperm. Studies have found that FETUB is elevated in type 2 diabetes patients and FETUB knockdown improves glucose metabolism in obese mice. FETUB is also an inhibitor of basic calcium phosphate, blocking unwanted calcification.
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別名:16G2 ELISA Kit; 2310011O17Rik ELISA Kit; AI255764 ELISA Kit; D17980 ELISA Kit; Fet ELISA Kit; Fetub ELISA Kit; FETUB_HUMAN ELISA Kit; Fetuin beta ELISA Kit; Fetuin-B ELISA Kit; Fetuin-like protein ELISA Kit; Fetuin-like protein IRL685 ELISA Kit; Gugu ELISA Kit; IRL685 ELISA Kit; Pp63 ELISA Kit
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縮寫:FETUB
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:0.137 ng/ml-100 ng/ml.
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靈敏度:0.137 ng/ml.
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Cardiovascular
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻
- Fetuin B alleviates testosterone propionate-induced oxidative stress and mitochondrial dysfunction in KGN cells by upregulating the TGFR2/SMAD3 pathway Y Gao,ResearchSquare,2022
- Proteomic Analysis of Serum from Patients with Major Depressive Disorder to Compare Their Depressive and Remission Statuses Jiyeong Lee et al, Psychiatry Investig,2015
相關(guān)產(chǎn)品
靶點詳情
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功能:Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.
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基因功能參考文獻:
- High Serum fetuin-B expression is associated with insulin resistance. PMID: 29194974
- fetuin B may serve as a potential biomarker for coronary artery disease PMID: 28822077
- Increased serum fetuin-B level was significantly associated with higher risk of insulin resistance. Common genetic variants of FETUB SNPs (rs4686434, rs6785067, and rs3733159) were significantly associated with serum fetuin-B concentrations but were not associated with insulin resistance. PMID: 29390354
- serum level of fetuin B in the control subjects was lower than it in nonalcoholic fatty liver disease patients. fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD. PMID: 27628583
- Further studies need to elucidate factors contributing to fetuin B regulation in humans, as well as the pathophysiological significance of fetuin B upregulation in gestational diabetes PMID: 28183456
- Data indicate that fetuin-B was one of the highly expressed serum proteins in acute myocardial infarction. PMID: 25671698
- Reduced expression of fetuin-b led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels. PMID: 22739111
- serum fetuin has a role in processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells PMID: 15280384
- results support the hypothesis that fetuin-A serum levels are associated with bone cell activity PMID: 16797392
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亞細胞定位:Secreted.
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蛋白家族:Fetuin family
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組織特異性:Liver and testis.
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數(shù)據(jù)庫鏈接:
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