Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human Matrin-3(MATR3) ELISA kit

Human Matrin-3(MATR3) ELISA kit

  • 中文名稱：
    人基質(zhì)蛋白-3(MATR3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL013525HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    This Human MATR3 ELISA Kit was designed for the quantitative measurement of Human MATR3 protein in serum, plasma,tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 23.5 pg/mL-1500 pg/mL and the sensitivity is 5.8 pg/mL.

  • 別名：
    ALS21 ELISA Kit; KIAA0723 ELISA Kit; Matr3 ELISA Kit; MATR3_HUMAN ELISA Kit; Matrin-3 ELISA Kit; Matrin3 ELISA Kit; MPD2 ELISA Kit; VCPDM ELISA Kit; Vocal cord and pharyngeal weakness with distal myopathy ELISA Kit
  • 縮寫：
    MATR3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates, cell lysates
  • 檢測范圍：
    23.5 pg/mL-1500 pg/mL
  • 靈敏度：
    5.8 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Epigenetics and Nuclear Signaling
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins.
  • 基因功能參考文獻：
    1. Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3. PMID: 27731383
    2. Using a novel RNA pulldown approach that utilized endogenous S1-tagged PINCR (a p53-regulated long noncoding RNA), the authors show that PINCR associates with the enhancer region of these genes by binding to RNA-binding protein Matrin 3 that, in turn, associates with p53. PMID: 28580901
    3. Matrin3 physically interacts with intronic pyrimidine-rich sequences and controls alternative splicing. PMID: 28695676
    4. It may not be a common genetic factor in Chinese amyotrophic lateral sclerosis patients. PMID: 26708275
    5. Its mutations strengthens the role of RNA metabolism in amyotrophic lateral sclerosis etiology. PMID: 26493020
    6. A missense mutation in MATR3 was identified in myopathy patients undergoing a needle electromyography. PMID: 26899464
    7. Our findings indicate that mutations in Matrin 3 that are associated with ALS and myopathy do not dramatically alter the normal localization of the protein or readily induce inclusion formation. PMID: 26528920
    8. Three-dimensional mapping of the lamin A-matrin-3 interface showed that the LMNA truncating mutation Delta303, which lacks the matrin-3 binding domain, was associated with an increased distance between lamin A and matrin-3. PMID: 25948554
    9. Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID: 26129669
    10. MATR3 mutation is identified to be a possible cause of amyotrophic lateral sclerosis. PMID: 25771394
    11. No mutations were identified, indicating that MATR3 mutations are not a common cause of Amyotrophic lateral sclerosis in Australian familial cases with predominately European ancestry PMID: 25523636
    12. MATR3 gene disruption is associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. PMID: 25574029
    13. Mutations in MATR3 are rare in French familial ALS and ALS with FTLD patients. PMID: 25158920
    14. This study shows a high risk of abnormal respiratory function with progressive worsening in MATR3 myopathy. PMID: 25677933
    15. Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB. PMID: 25599992
    16. the pY RNA1-s2/Matr3 interaction could play a role in vision PMID: 24558381
    17. Sixteen patients from 6 families with late onset distal myopathy associated with the p.S85C MATR3 mutation were characterized. PMID: 25154462
    18. This study identified mutations in MATR3 in ALS kindreds. also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. PMID: 24686783
    19. Data suggest that the cellular level of MATR3, known to be highly regulated, modulates the stability of a group of gene transcripts. PMID: 21858232
    20. Rev needs MATR3 to promote the cytoplasmic accumulation and translation of unspliced RRE-containing mRNA. PMID: 21771348
    21. MATR3 binds viral RNA and is required for the Rev/RRE mediated nuclear export of unspliced HIV-1 RNAs. PMID: 21771346
    22. Matrin 3 binds Rev RNA to stabilize HIV-1 transcripts leading to increased cytoplasmic expression. PMID: 21771347
    23. MATR3 to be a novel ATM target in response to DNA damage. PMID: 20421735
    24. matrin 3 plays a significant role in controlling cell growth and proliferation PMID: 21182838
    25. study of the association of matr3 with chromosome territories and identification of potential interacting proteins PMID: 19562669
    26. Data show that the nuclear matrix protein matrin 3, cytoskeletal motor protein HMP, and the circadian clock protein lark were significantly decreased in fetal Down syndrome brain. PMID: 12469345
    27. These results suggest that the functions of matrin 3 could be regulated by both Ca(2+)-dependent interaction with calmodulin and caspase-mediated cleavage. PMID: 17658460
    28. the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1gamma, RNA polymerase II, matrin 3, and SAF-A sites PMID: 18618731
    29. nonconservative S85C missense mutation in vocal cord and pharyngeal weakness with distal myopathy PMID: 19344878

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Amyotrophic lateral sclerosis 21 (ALS21)
  • 亞細胞定位：
    Nucleus matrix.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6912

    OMIM: 164015

    KEGG: hsa:9782

    STRING: 9606.ENSP00000354346

    UniGene: Hs.268939