Human Thymosin β4 ELISA Kit
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中文名稱:人胸腺肽β4(Thymosin β4)酶聯(lián)免疫試劑盒
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貨號:CSB-E11910h
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:
This Human TMSB4X ELISA Kit was designed for the quantitative measurement of Human TMSB4X protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 78 ng/mL-5000 ng/mL and the sensitivity is 19.5 ng/mL .
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別名:Fx ELISA Kit; Hematopoietic system regulatory peptide ELISA Kit; Prothymosin beta 4 ELISA Kit; PTMB 4 ELISA Kit; PTMB4 ELISA Kit; Seraspenide ELISA Kit; T beta 4 ELISA Kit; T beta-4 ELISA Kit; TB4X ELISA Kit; THYB 4 ELISA Kit; Thyb4 ELISA Kit; Thymosin beta 4 ELISA Kit; Thymosin beta 4 X chromosome ELISA Kit; Thymosin beta 4 X linked ELISA Kit; TMSB 4 ELISA Kit; TMSB4 ELISA Kit; Tmsb4x ELISA Kit; TYB4_HUMAN ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:78 ng/mL-5000 ng/mL
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靈敏度:19.5 ng/mL
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Signal Transduction
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human thymosin β4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 88 Range % 84-96 1:2 Average % 98 Range % 92-105 1:4 Average % 94 Range % 90-102 1:8 Average % 97 Range % 92-106 -
回收率:
The recovery of human thymosin β4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 89 82-94 EDTA plasma (n=4) 102 96-108 -
標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. ng/ml OD1 OD2 Average Corrected 5000 2.411 2.312 2.362 2.206 2500 1.835 1.736 1.786 1.630 1250 1.212 1.203 1.208 1.052 625 0.703 0.694 0.699 0.543 312 0.394 0.404 0.399 0.243 156 0.277 0.286 0.282 0.126 78 0.223 0.228 0.226 0.070 0 0.155 0.156 0.156 -
數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Thymosin β4, a potential marker of malignancy and prognosis in hepatocellular carcinoma W Wang,Scandinavian Journal of Gastroenterology,2022
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
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基因功能參考文獻(xiàn):
- Serum Tbeta4 level can be used as a biomarker for the diagnosis of NASH and was negatively correlated with the oxidation state of the liver PMID: 29271227
- we suggest that overexpression of Tbeta4 might play a role in the progression of gastric gastrointestinal stromal tumors PMID: 28756979
- Tbeta4 exerts a protective effect on murine colitis, indicating that recombinant adeno-associated virus carrying thymosin beta4 could potentially be developed into a promising agent for the therapy of inflammatory bowel diseases. PMID: 28127198
- Results showed that the TMSB4 pseudogene, lncRNA-MSR, was upregulated in the damaged cartilage and was activated in chondrocytes in response to mechanical stress. Furthermore, lncRNA-MSR regulated the expression of TMSB4 by competing with miRNA-152 in chondrocytes. PMID: 27469625
- Tbeta4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo. Mechanistic investigations revealed a significant decrease in Notch1 activation in Tbeta4 gene-silenced cells. PMID: 27521796
- Developed an innovative biotechnological method for thymosin beta4 production that employs the peptide acetylation in vivo. PMID: 27015974
- Serum thymosin beta4 concentrations were correlated with the occurrence and severity of obstructive sleep apnea syndrome. PMID: 27086675
- Overexpression of Tbeta4 enhanced cell proliferation and colony formation in oral squamous cell carcinoma. PMID: 26276576
- Tbeta-4 was validated in clinical samples using a tissue microarray to predict overall survival in colon cancer patients PMID: 26556858
- this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro. PMID: 26789270
- this study demonstrates, for the first time, that Tbeta4 is expressed in developing periodontal tissue and that its expression is associated with osteoblastic/cementoblastic differentiation. PMID: 26361868
- This article reviews the potential role of thymosin beta 4 in liver fibrosis by describing the effects of exogenous and endogenous thymosin beta 4 , and discusses the possible signaling pathway regulated by TB4X. [review] PMID: 26006229
- The results of the present study suggested that Tb4 may promote HB metastasis via the induction of EMT, and that Tb4 may therefore be a target for the development of novel treatments for patients with Hepatoblastoma . PMID: 25695679
- these results suggest that NO could regulate the expression of Tbeta4 by direct or indirect effect of HIF-1alpha on Tbeta4 promoter. PMID: 25271630
- the exchange of bound actin between Tbeta4 and profilin involves both steric and allosteric components. PMID: 25313062
- Thymosin beta4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/beta-catenin signaling pathway. PMID: 25218472
- Regarding HCC, Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC to human cancers that express these beta-thymosins. PMID: 24704991
- Thymosin beta-4 levels in the serum and synovial fluid of knee osteoarthritis patients are significantly correlated with disease severity. PMID: 23816466
- Thymosin beta 4 silencing in glioblastoma cells inhibits cell migration and invasion. PMID: 24355709
- cell trafficking of thymosin beta-4 PMID: 23967050
- Tbeta4 expression was upregulated significantly in primary and recurrent colorectal cancers PMID: 24098025
- Tbeta4 expression was also co-localized with CD133 expression in primary ovarian carcinomas. PMID: 23055022
- Detection its amino acid conservation suggest an important role of Tb4 in the homeostasis of the mammalian oral cavity. PMID: 23262355
- Thymosin beta4 could be associated with morphogenesis and tumor invasion in ameloblastoma and may play a role in the behavior of ameloblastoma. PMID: 23235961
- Tbeta4 plays a key role in odontoblastic differentiation of human dental pulp cells. PMID: 23613983
- Tbeta4 is an important myocardin-related transcription factor (MRTF) regulator that controls the G-actin-MRTF-A interaction.Tbeta4 competed with MRTF-A for G-actin binding, thus interfering with G-actin-MRTF-A complex formation. PMID: 23811404
- REVIEW: role of Tbeta4 in thrombosis and platelet aggregation PMID: 22944663
- Thymosin beta4 expression reveals intriguing similarities between fetal and cancer cells. PMID: 23045970
- investigated whether GSK-3 activity is regulated by thymosin beta-4 (Tbeta4) and associated with Tbeta4-mediated migration in gastric cancer cells; expression of GSK-3alpha, beta-catenin and E-cadherin could be negatively regulated by Tbeta4 induced ERK phosphorylation; suggests that Tbeta4 could be a novel regulator to control Wnt signal pathway PMID: 22328534
- The Our data confirm the concept that externally added Tbeta4 must be internalized to induce intracellular mechanisms supporting endothelial cell migration. PMID: 22652458
- Thymosin beta4 Tbeta4 may play an important role in bone degradation and inflammation in RA but not OA. PMID: 22004227
- kininogen-1 and thymosin-beta(4) are potential new biomarkers for human chronic hepatitis C. PMID: 21496200
- Tbeta4 is regulated by IL-18 and is involved in IL-18-enhanced IFN-gamma secretion in NK cells. PMID: 21742406
- Elevated expression of thymosin beta4 is associated with early-stage cervical cancers. PMID: 21213129
- Thymosin beta4 may play a role in diabetic retinal neovascularization. PMID: 21332672
- findings suggest that Tbeta4 by sequestering actin prevents binding of AKT, thus inhibiting its phosphorylation PMID: 21514425
- The expression of thymosin beta4 is highly related with tumorigenesis of certain tumors including the osteosarcoma and colorectal cancers. PMID: 20975530
- Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. PMID: 21314931
- we have identified an extracellular signaling pathway where Tbeta4 increases cell surface ATP levels via ATP synthase and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced cell migration PMID: 21106936
- overexpression of Tbeta4 is strongly associated with HIF-1alpha and HIF-2alpha expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer PMID: 21109953
- The TB4 could be a hypoxia responsive regulator to control tumor cell migration in angiogenesis and tumor metastasis. PMID: 20821256
- colorectal cancer stem cells from different patients have higher Tbeta4 levels than normal epithelial cells PMID: 20566622
- Data in colon cancer tissue microarray showed that thymosin beta4 and HIF-1alpha co-localized in these biopsies. PMID: 20691219
- Data show a strong expression of Tbeta(4) in gut and endocrine pancreas during development. PMID: 20161756
- study demonstrated a clear relationship between reductions in serum thymosin beta4 level and severity of hepatitis B virus-related liver failure PMID: 20128033
- Data show that thymosin beta4 was differentially expressed in HGF-treated HUVECs compared with control. PMID: 12163032
- araC regulates the transcriptional level of thymosin beta4 and actin PMID: 12962156
- in response to T beta 4 stimulation, AP-1 activity increases to enhance PAI-1 transcription through its unique AP-1-like element at -59 to -52 in the PAI-1 promoter. PMID: 14592829
- upregulation of Tbeta-4, by promoting the disruption of cell-cell adhesion and consequential activation of the beta-catenin signaling, could be event in the acquisition of growth advantages as well as invasive phenotypes in human colorectal carcinomas PMID: 15235586
- activated factor XIII incorporates thymosin beta(4) into the isolated gamma-module and alphaC-domain (fibrinogen A alpha); in fibrin the latter serves as the major incorporation site PMID: 15311936
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亞細(xì)胞定位:Cytoplasm, cytoskeleton.
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蛋白家族:Thymosin beta family
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組織特異性:Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.
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