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  4. Human Troponin I, fast skeletal muscle(TNNI2) ELISA kit

Human Troponin I, fast skeletal muscle(TNNI2) ELISA kit

  • 中文名稱：
    人肌鈣蛋白I，骨骼肌快肌(TNNI2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL024012HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    This Human TNNI2 ELISA Kit was designed for the quantitative measurement of Human TNNI2 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 15.6 pg/mL-1000 pg/mL and the sensitivity is 3.9 pg/mL.

  • 別名：
    AMCD 2B ELISA Kit; AMCD2B ELISA Kit; DA 2B ELISA Kit; DA2B ELISA Kit; fast skeletal muscle ELISA Kit; Fast twitch skeletal muscle troponin I ELISA Kit; fast-twitch isoform ELISA Kit; FSSV ELISA Kit; fsTnI ELISA Kit; TNNI 2 ELISA Kit; Tnni2 ELISA Kit; TNNI2_HUMAN ELISA Kit; tro ELISA Kit; Troponin I ELISA Kit; Troponin I fast skeletal muscle ELISA Kit; Troponin I fast twitch 2 ELISA Kit; Troponin I fast twitch isoform ELISA Kit; Troponin I fast twitch skeletal muscle isoform ELISA Kit; Troponin I skeletal fast ELISA Kit; Troponin I type 2 (skeletal fast) ELISA Kit; Troponin I type 2 ELISA Kit
  • 縮寫：
    TNNI2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

問答及客戶評論

■ 常見問題解答
Q:

Per customer request, can you please provide the following information about this kit:
a. Capture antibody or capture antigen – immunogen type, sequence (including species source and accession no. if available), expression host, clonality and host species.
b. Detection antibody (if applicable) - immunogen type, sequence (including species source and accession no. if available), expression host, clonality and host species.
c. Standard – if recombinant protein please specify sequence (including species source and accession no. if available) and expression host.
d. The customer is asking about cross-reactivity with homologous proteins, espessialy with cTnI. Did you test it? Can you please provide such kind of information with data?

A:
Thanks for your inquiry!
CSB-EL024012hu
This kit is designed against full length protein.
Capture antibody is goat polyclonal antibody.
Detection antibody is goat polyclonal antibody.
Immunogen of capture antibody is 293 cell derived recombinant protein, full length.
Immunogen of detection antibody is 293 cell derived recombinant protein, partial.
Standard is 293 cell derived recombinant protein.There is no cross reactivity with cTnI.

靶點(diǎn)詳情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. PMID: 28436080
    2. TNNI2 gene missense mutation is associated with distal arthrogryposis type 1. PMID: 26374086
    3. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism PMID: 23850728
    4. Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis. PMID: 22519952
    5. Atrial re-expression of ssTnI during paroxysmal atrial fibrillation in patients does not seem to be part of the process of AF-associated cardiomyocyte dedifferentiation but seems to result from transient cardiomyocyte stress at the onset of AF. PMID: 15289369
    6. study found a novel TNNI2 mutation in a Chinese family with distal arthrogryposis type 2B PMID: 16802141
    7. Implantation of stable human clone expressing fast-twitch skeletal muscle troponin I in female BALB/c nude mice inhibits primary tumor growth and suggests that grafts are self-inhibitory by halting angiogenesis. PMID: 17393089
    8. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha. PMID: 18331830
    9. Data found that fTnI normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnI transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes. PMID: 18548613
    10. Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. PMID: 18805052

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  • 相關(guān)疾病：
    Arthrogryposis, distal, 2B (DA2B)
  • 蛋白家族：
    Troponin I family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11946

    OMIM: 191043

    KEGG: hsa:7136

    STRING: 9606.ENSP00000252898

    UniGene: Hs.523403