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  4. Human cardiac troponin Ⅰ,cTn-ⅠELISA Kit

Human cardiac troponin Ⅰ,cTn-ⅠELISA Kit

  • 中文名稱：
    人心肌肌鈣蛋白Ⅰ(cTn-Ⅰ)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E05139h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    This Human TNNI3 ELISA Kit was designed for the quantitative measurement of Human TNNI3 protein in serum, plasma, urine. It is a Sandwich ELISA kit, its detection range is 47 pg/mL-3000 pg/mL and the sensitivity is 11.75 pg/mL .

  • 別名：
    cardiac muscle ELISA Kit; Cardiac troponin I ELISA Kit; cardiomyopathy; dilated 2A (autosomal recessive) ELISA Kit; Cardiomyopathy; familial hypertrophic; 7; included ELISA Kit; CMD1FF ELISA Kit; CMD2A ELISA Kit; CMH7 ELISA Kit; cTnI ELISA Kit; Familial hypertrophic cardiomyopathy 7 ELISA Kit; MGC116817 ELISA Kit; RCM1 ELISA Kit; Tn1 ELISA Kit; Tni ELISA Kit; TNN I3 ELISA Kit; TNNC 1 ELISA Kit; TNNC1 ELISA Kit; TNNI3 ELISA Kit; TNNI3_HUMAN ELISA Kit; Troponin I ELISA Kit; Troponin I cardiac ELISA Kit; Troponin I cardiac muscle ELISA Kit; Troponin I cardiac muscle isoform ELISA Kit; Troponin I type 3 cardiac ELISA Kit; troponin I; cardiac 3 ELISA Kit; TroponinI ELISA Kit; Ttroponin I type 3 (cardiac) ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    47 pg/mL-3000 pg/mL
  • 靈敏度：
    11.75 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human cTn-Ⅰ in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %94
    Range %90-100
    1:2Average %92
    Range %83-101
    1:4Average %93
    Range %85-103
    1:8Average %95
    Range %90-102
  • 回收率：
    The recovery of human cTn-Ⅰ spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9784-110
    EDTA plasma (n=4)9689-103
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    30002.362 2.407 2.385 2.238
    15001.421 1.453 1.437 1.290
    7500.852 0.846 0.849 0.702
    3750.489 0.512 0.501 0.354
    187.50.323 0.336 0.330 0.183
    940.280 0.286 0.283 0.136
    470.228 0.227 0.228 0.081
    00.146 0.147 0.147 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis]. PMID: 29631448
    2. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review]. PMID: 28545334
    3. the frequency of h-FABP positivity among acute myocardial infarction patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI area under curve was superior to that of h-FABP. PMID: 28650717
    4. Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ. PMID: 29558109
    5. The QT interval has a strong positive linear correlation with cardiac troponin-I levels in Non-ST-elevation myocardial infarction. PMID: 28366473
    6. Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE. PMID: 28728608
    7. In clinical stable patients without known cardiovascular disease, a thorough chest-pain history in combination with hs-TnI testing can identify a significant low-risk group. PMID: 28031149
    8. Study showed that in patients who underwent liver transplantation elevation of preoperative high-sensitivity cardiac troponin I level was associated with 1-year mortality and 30-day mortality. PMID: 28542299
    9. Serial measurement of troponin I revealed a persistent elevation in patients with diabetes mellitus type 2. PMID: 28246236
    10. Plasma troponin C1 (cTnI) is biomarker of choice for diagnosing acute myocardial infarction (AMI) because of its high specificity as biomarker for damage to myocardial tissue. Data suggest the "best cut-off" for plasma cTnI is 0.014 micrograms/L in AMI. These studies were conducted in emergency department of a university hospital in Italy using point-of-care testing in patients presenting with chest pain, ages 18-101. PMID: 28377153
    11. NT-proBNP and hs-cTnI levels were higher in systemic sclerosis patients than controls. Both NT-proBNP and hs-cTnI were associated with the presence of echocardiographic abnormalities. PMID: 27601074
    12. value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following liver transplantation with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation. PMID: 28455997
    13. cTnI levels are common in Fabry disease patients, reflecting cardiac involvement. PMID: 27322070
    14. Report novel troponin I rule-out value below the upper reference limit for acute myocardial infarction. PMID: 27067356
    15. cTnI determined in hemodynamically stable patients with suspected AMI and wide QRS complex using optimized diagnostic thresholds improves rule-in and rule-out with respect to presence of a significant obstructive CAD PMID: 27148734
    16. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP), troponin I, and YKL-40. PMID: 27760764
    17. Serum cardiac troponin I was increased in septic patients with myocardial depression compared to those without myocardial depression. PMID: 27238916
    18. Elevated BNP and hs-cTnI after kidney transplantation identify candidates for targeted risk reduction. PMID: 26910333
    19. These perturbed biophysical and biochemical myofilament properties are likely to significantly contribute to the diastolic cardiac pump dysfunction that is seen in patients suffering from a restrictive cardiomyopathy that is associated with the cTnI R145W mutation. PMID: 27557662
    20. epigenetic modification caused cTnI expression decrease is one of the possible causes that result in a reduced cTnI level and diastolic dysfunction in older mouse hearts PMID: 27184165
    21. Among hospitalized patients with cardiac troponin I values above 30 ng/L, the majority will have myocardial injury. Cardiac nonischemic conditions are associated with very high troponin concentrations, but the outcome is rather good. In contrast, myocardial injury related to noncardiac or multiple conditions carries a very poor long-term prognosis. PMID: 26763756
    22. troponin I carboxy terminal mobile domain and linker sequence has a role in regulating cardiac contraction PMID: 26971468
    23. the last 5 C-terminal residues of cTnI influence the binding of cTnI with cTnC and cTnT and affect the Ca(2+) dependence of filament sliding PMID: 26919894
    24. Study found that N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I are independently associated with incident dementia and NT-proBNP with incident Alzheimer's disease PMID: 28039523
    25. The clones were selected using microtiter plate coated with human cardiac troponin I (hcTnI). Product of hybridoma cells that bind with high affinity to human cardiac troponin I were selected PMID: 27556913
    26. Sex, age, and systolic blood pressure belong to the strongest determinants of hs-cTnI in healthy adults. PMID: 27535138
    27. This review summarizes the recent proteomic data on aminoacid sequences of cTnT and cTnI in various species, as well as selected analytical characteristics of human cardiac troponin high-sensitivity assays PMID: 26876101
    28. In stable coronary artery disease patients successfully treated with PCI, pre-procedural cTnI levels, in the upper limits of the normal range, are associated with hard cardiac endpoints. PMID: 25405803
    29. Calcium channel blockers and adrenergic beta antagonists reduced hs-TnI levels significantly both at rest and during exercise in atrial fibrillation patients/. PMID: 27142292
    30. Compromised interactions of K206I with actin and hcTnC may lead to impaired relaxation and HCM. PMID: 26553696
    31. hsTnI at the time of presentation followed by early advanced coronary CTA assessment improves the risk stratification and diagnostic accuracy for acute coronary syndromes. PMID: 26476506
    32. These findings showed that a double heterozygous mutation in the TNNI3 gene is involved in the pathogenesis of hypertrophic cardiomyopathy via haploinsufficiency. PMID: 26506446
    33. The incidence of adverse cardiovascular events was significantly higher in patients with troponin elevation after carotid endarterectomy, which was mainly attributable to silent non-ST segment elevation MIs that occurred in the early post-operative phase. PMID: 26553374
    34. Four novel missense variants were identified in TNNI3. PMID: 26169204
    35. Letter/Case Report: acute decompensated heart failure with troponin I elevation in hereditary hemochromatosis. PMID: 25916738
    36. In this pilot study, the addition of CACS to hsTnI improves the identification of low-risk subjects in whom CTA might be avoided. PMID: 26049777
    37. Exclusion of acute myocardial infarction 2h after presentation in emergency patients with possible acute coronary syndrome can be achieved using hs-cTnT or hs-cTnI assays. PMID: 24316100
    38. Hybrid coronary revascularization is associated with lower postoperative cTn release, compared with off-pump coronary artery bypass surgery. PMID: 25217621
    39. Carotid endarterectomy is followed by a high incidence of asymptomatic cTnI increase that is associated with late cardiac events. PMID: 25601178
    40. mutations underlying restrictive cardiomyopathy all marked by right-sided cardiac manifestations in South African patients PMID: 25940119
    41. Circulating levels of sensitive cTnI and NT-proBNP are related to LV function and infarct size in patients with stable CAD after revascularization. PMID: 25788439
    42. Serum TnI detected significant myocardial necrosis in a majority of patients with chronic HF due to LVSD and when measured serially, provided independent risk information for poor CV outcomes and deleterious LV remodeling. PMID: 25777344
    43. The elevation of Tn I after PCI in patients with normal initial level is more significant predictor of early (30-day) mortality compared to later (within 12 months) mortality. PMID: 25617100
    44. AF patients both without and with CAD showed similar cTnI concentrations at admission. A second validation of cTnI is mandatory for all patients. PMID: 25653186
    45. cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction PMID: 25381953
    46. Even a single elevated Troponin I value increased the risk of myocardial infarction. PMID: 25195101
    47. Abbott high-sensitivity cardiac-TnI levels in a total of 3314 Korean patients with chest pain, were determined. PMID: 25887868
    48. Absolute delta performed significantly better than relative delta at all time intervals to measure changes in troponin I for early diagnosis of myocardial infarction. PMID: 25261587
    49. The high accordance with LGE, reflecting cardiac dysfunction, suggests that cTNI-elevation can be a useful laboratory parameter for assessing myocardial damage in FD. PMID: 24626231
    50. Using an overall 99th percentile for cTnI does not appear to increase the prevalence of myocardial injury or lead to further hospital admissions from the emergency department. PMID: 26185217

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  • 相關(guān)疾病：
    Cardiomyopathy, familial hypertrophic 7 (CMH7); Cardiomyopathy, familial restrictive 1 (RCM1); Cardiomyopathy, dilated 2A (CMD2A); Cardiomyopathy, dilated 1FF (CMD1FF)
  • 蛋白家族：
    Troponin I family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11947

    OMIM: 115210

    KEGG: hsa:7137

    STRING: 9606.ENSP00000341838

    UniGene: Hs.709179