Human glycoprotein 130,gp130 ELISA KIT

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.; Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response. Also blocks IL11 cluster signaling through IL11R.

1. Low soluble glycoprotein 130 (sgp130) level may serve as an additional indicator of coronary atherosclerosis severity. PMID: 29580104
2. we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex. PMID: 29237553
3. SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage. PMID: 28964648
4. Low levels of serum sgp130 were positively associated with sex hormones in male patients with coronary artery disease, suggesting an important role of sgp130 in the presence of low and imbalanced sex hormones levels. PMID: 29028483
5. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130. PMID: 29038846
6. gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer. PMID: 27917904
7. GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. PMID: 28356514
8. Data show that tumor suppressor adenomatous polyposis coli (APC) loss results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating YAP (YY1-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC). PMID: 28130546
9. an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation. PMID: 27489351
10. age 3 plasma levels of sGP130 were found related to childhood asthma PMID: 27434124
11. This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease. PMID: 27053713
12. we developed a CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decreased their expression PMID: 26969735
13. Intracellular p19 associated with the cytokine receptor subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3) signaling PMID: 26980441
14. High serum GP130 levels were associated with Chronic Spontaneous Urticaria. PMID: 26699882
15. Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. PMID: 26188635
16. In the present study, we analyze the role of a unique cysteine residue (Cys-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms. PMID: 26809098
17. pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements PMID: 26589480
18. Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway. PMID: 26191141
19. Data (including data from molecular dynamics simulation studies) suggest that conformation of GP130 (domains 2 and 3) changes and fluctuates only modestly (inter-domain angles vary only 125-140 degrees). PMID: 25243707
20. GP130 signaling collaborated with MYC to induce MM and was responsible and sufficient for directing the plasma cell phenotype. PMID: 25384216
21. GP130/STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis. PMID: 25747354
22. NDRG2/gp130/STAT3 pathway can mediate the antimetastatic effects of Dp44mT in hepatocellular carcinoma. PMID: 25261367
23. Candidate gene IL6ST were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status. PMID: 24656773
24. Recombinant sgp130-E10Fc binds to a complex of IL-6 and sIL-6R, but not to IL-6 alone, and specifically inhibits IL-6 trans-signaling. Thus, it might play an important role in the regulation of trans-signaling in vivo. PMID: 24973212
25. Low incidence of IL6ST mutations in exon 6 are associated with lung cancer. PMID: 25242236
26. However, activation of the gp130 cell surface receptor is both necessary and sufficient for downregulation of TGF-beta2 in Kaposi's sarcoma-associated herpesvirus-infected cells. PMID: 25275137
27. This review showed that Humanin is a a possible linkage between Alzheimer's disease and type 2 diabetes. PMID: 24365186
28. Aberrant signalling from intracellular compartments might explain the tumorigenic potential of naturally occurring somatic mutations of gp130. PMID: 24213527
29. Data suggest women with inflammatory hepatic adenoma exhibit mutations in gp130/IL6ST (glycoprotein subunit 130, interleukin-6 receptor, HNF1A (hepatic nuclear factor 1 alpha), and CTNNB1 (beta-catenin). [REVIEW] PMID: 25076298
30. serum level decreased in early onset severe pre-eclampsia PMID: 23782174
31. ERK2 binds to the GP130 promoter, where it perhaps interacts with the transcriptional machinery. PMID: 23686311
32. Sgp130 serum levels are significantly higher in subjects carrying the gp130 polymorphism G148C compared to wildtype carriers. PMID: 24629561
33. Higher expression of p-p38, p-C-JUN, p-STAT3, and p-gp130 in the MBC-B group. PMID: 23813018
34. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes PMID: 23536726
35. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway. PMID: 23818941
36. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells. PMID: 24191003
37. Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3. PMID: 24082147
38. Data suggest that soluble gp130 has a role in prostate cancer invasion in an interleukin-6 dependent and independent manner. PMID: 21944124
39. Data suggest flavanoids (naringenin, flavone) suppress interleukin-6/IL6ST signaling and induce expression of SOCS3 (signal transducer and activator of transcription 3) in vascular endothelium; thus, dietary factors act as anti-inflammatory agents. PMID: 23782265
40. gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
41. interleukin-6 receptor polymorphism may be a contributing factor in Castleman Disease, and further research is warranted. PMID: 23372742
42. In a laboratory study, addition of gp130 to culture media improves blastocyst formation and implicates a physiological role in regulating preimplantation development in humans. PMID: 23375201
43. Data indicate that active cruzipain completely abrogated the STAT3 phosphorylation and enzymatically cleaved gp130 ectodomain. PMID: 23253440
44. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. PMID: 23209286
45. gp130 activation is regulated by D2-D3 interdomain connectivity. PMID: 23294003
46. Gp130 mRNA was hardly detectable in endometrium of both fertile and infertile women with no difference between them. Infertile women secreted significantly less gp130 molecules in the uterine flushing compared with fertile women. PMID: 22520363
47. Together these results suggest that the inhibitory effect of OSM on TGF-beta1-induced CTGF mRNA expression is mainly driven by STAT3, thereby providing a signaling mechanism whereby OSM may contribute to tubulointerstitial protection. PMID: 22814105
48. the mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling PMID: 22523320
49. gp130 regulates interleukin 6 signalling as an antagonist in cerebrospinal fluid immediately after subarachnoid haemorrhage PMID: 20660911
50. The IL-6/gp130 signaling pathway is dierctly involved in amyloid-beta precursor protein (APP)-induced glial differentiation. PMID: 20309664

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[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Type I cytokine receptor family, Type 2 subfamily

Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.; [Isoform 2]: Expressed in blood serum (at protein level).

HGNC: 6021

OMIM: 600694

KEGG: hsa:3572

STRING: 9606.ENSP00000338799

UniGene: Hs.532082