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  4. Human heart fatty acid binding protein,h-FABP ELISA Kit

Human heart fatty acid binding protein,h-FABP ELISA Kit

  • 中文名稱：
    人心型脂肪酸結(jié)合蛋白(h-FABP)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09185h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        心型脂肪酸結(jié)合蛋白（Fatty acid-binding protein 3，F(xiàn)ABP3），是一種在心臟、肌肉和脂肪組織等處表達(dá)的細(xì)胞內(nèi)蛋白，參與脂肪酸的轉(zhuǎn)運(yùn)和代謝，與心肌梗死等心臟疾病有關(guān)。
        華美生物所提供的Human heart fatty acid binding protein,h-FABP ELISA Kit屬于ELISA檢測試劑盒，采用雙抗夾心法定量檢測人血清、血漿、組織勻漿樣本中的FABP3，其靈敏度為19.5 pg/mL，檢測范圍為78 pg/mL-5000 pg/mL。
     
  • 別名：
    422 protein ELISA Kit; Cardiac FABP ELISA Kit; Cardiac Fatty Acid Binding Protein ELISA Kit; FABP 11 ELISA Kit; FABP 3 ELISA Kit; FABP11 ELISA Kit; FABP3 ELISA Kit; FABPH_HUMAN ELISA Kit; Fatty acid binding protein 11 ELISA Kit; Fatty acid binding protein 3 ELISA Kit; Fatty acid binding protein 3 muscle and heart ELISA Kit; Fatty acid binding protein 3 muscle and heart mammary derived growth inhibitor ELISA Kit; Fatty acid binding protein 3 muscle ELISA Kit; Fatty acid binding protein 3; muscle and heart (mammary derived growth inhibitor) ELISA Kit; Fatty acid binding protein 3; muscle ELISA Kit; Fatty acid binding protein heart ELISA Kit; Fatty acid binding protein; heart ELISA Kit; Fatty acid binding protein; muscle and heart ELISA Kit; Fatty acid binding protein; skeletal muscle ELISA Kit; Fatty acid-binding protein 3 ELISA Kit; Fatty acid-binding protein ELISA Kit; H FABP ELISA Kit; H-FABP ELISA Kit; heart ELISA Kit; Heart type fatty acid binding protein ELISA Kit; Heart-type fatty acid-binding protein ELISA Kit; M FABP ELISA Kit; M-FABP ELISA Kit; Mammary derived growth inhibitor ELISA Kit; Mammary-derived growth inhibitor ELISA Kit; MDGI ELISA Kit; Muscle fatty acid binding protein ELISA Kit; Muscle fatty acid-binding protein ELISA Kit; Mylein protein P2 homolog ELISA Kit; O FABP ELISA Kit; OTTHUMP00000003898 ELISA Kit; P2 adopocyte protein ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    脂肪酸結(jié)合蛋白3（FABP3），也稱為心肌型脂肪酸結(jié)合蛋白（H-FABP），是一種小分子蛋白質(zhì)，主要在心肌和骨骼肌中表達(dá)。最新的研究表明，F(xiàn)ABP3可以作為心肌梗死的生物標(biāo)志物，在早期診斷和評估患者的病情嚴(yán)重程度方面具有潛在的臨床應(yīng)用。此外，F(xiàn)ABP3在心肌細(xì)胞中的表達(dá)也與心肌細(xì)胞存活和損傷修復(fù)相關(guān)，可能成為心臟疾病治療的潛在靶點(diǎn)。除此之外，F(xiàn)ABP3還參與調(diào)控脂肪代謝和炎癥反應(yīng)等生物學(xué)過程。
  • 功能：
    FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
  • 基因功能參考文獻(xiàn)：
    1. the frequency of h-FABP positivity among acute myocardial infarction patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI area under curve was superior to that of h-FABP. PMID: 28650717
    2. The present study demonstrated that pre-operative FABP3 gene expression in the atrium is reduced in patients with post-operative atrial fibrillation, independent of age and left atrial diameter. These findings suggest a potential link between altered fatty acid transport in the atrium and increased AF onset after cardiac surgery PMID: 28807550
    3. This study demonstrated that FABP3 CSF levels were increased in the Alzheimer's disease and dementia with Lewy bodies groups compared with the other neurological diseases and Parkinson's disease groups. PMID: 28750675
    4. Data suggest H-FABP as a potential marker for indicating myocardial ischemia. PMID: 28077344
    5. Serum levels of FABP3 in polymyositis/dermatomyositis patients were significantly increased and were mainly distributed in slow twitch muscle fibers, displaying a closer association with muscle weakness than did serum levels of CK and myoglobin. PMID: 26891180
    6. data indicate that FABP3 may in be part involved in ARA uptake in these cells and its expression may be regulated by ARA, insulin, LXR and the state of cellular differentiation. PMID: 28515017
    7. The higher interaction footprint of aptamer N53 incited synergistic conformational changes in both N53 and FABP3 during interaction, leading to a decline in binding affinity in comparison to aptamer N13 which corroborated to the calculated Kd values. PMID: 27545084
    8. There was no significant correlation between H-FABP, free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) levels in hyperthyroid patients PMID: 26859315
    9. For patients recruited PMID: 28419114
    10. significantly correlated to the major adverse events during hospitalization for acute pulmonary embolism PMID: 27916210
    11. HFABP expression is significantly elevated in in-stent coronary resteonisis . Overexpression of HFABP induces multiple pathway-related promotion of inflammation, growth and migration in vascular smooth muscle cells. PMID: 27372431
    12. cardiac damage in patients with CO poisoning could be partially mediated by CO-induced oxidative stress, where H-FABP3 level was directly and strongly associated with MDA and ADMA levels PMID: 27150386
    13. findings demonstrate the interobserver reliability of a qualitative point of care h-FABP assay PMID: 27363942
    14. Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression PMID: 26867681
    15. FABP3 expression was significantly lower in the schizophrenia group than in the control group. PMID: 26792082
    16. This study demonstrated that CSF FABP-3 may be an early marker for later development of dementia. PMID: 26484922
    17. Bedside H-FABP measurements may contribute to correct early diagnoses, as its levels are elevated soon following myocardial infarction, and measurement is easy, with a rapid result. PMID: 26212703
    18. Perioperative plasma H-FABP levels may be used for risk stratification of acute kidney injury and mortality following cardiac surgery. PMID: 25830762
    19. The C/G-G/G haplotype at RS2271072 and RS10914367 single nucleotide polymorphism of FABP3 might be a prognostic factor in patients with coronary atherosclerosis. PMID: 24695477
    20. FABP3 was increased in patients with acute heart failure compared to those without. PMID: 26072112
    21. H-FABP may have a role in occurrence of adverse clinical outcome in pulmonary embolism [meta-analysis] PMID: 25456730
    22. polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization PMID: 26206228
    23. A combination of FABP3 and IL-6 has an additive clinical value for prediction of cerebral infarction outcome. PMID: 23497639
    24. plasma level of H-FABP at 24h after the event may be an early and independent factor associated with survival to discharge in out-of-hospital cardiac arrest PMID: 24785584
    25. Serum H-FABP levels progressively increased from the control group to the OH group. PMID: 25234940
    26. Elevated H-FABP serum levels in patients with essential hypertension were predictive of future cardiovascular events. PMID: 25147067
    27. The frameshift and missense mutations in FABP3, FABP5, and FABP7 genes have been identified in schizophrenia and autism spectrum disorder in humans and in mouse behavioral studies. PMID: 25027319
    28. H-FABP level was increased in association with greater numbers of cardiovascular risk factors and was an independent risk factor for all-cause and cardiovascular deaths. PMID: 24847804
    29. Report correlation between preoperative serum h-FABP and the postoperative incidence of acute kidney injury in cardiac surgery patients. PMID: 25212385
    30. Studied the relationship between severity of CAD and heart-type fatty acid-binding protein (H-FABP)in patients with non-ST-segment elevation acute coronary syndrome. PMID: 24164992
    31. The s-H-FABP level is an effective biomarker for risk stratification in non-surgical intensive care patients. PMID: 24817549
    32. The levels of H-FABP, NT-proBNP, and cTnI were correlated with heart function, and can be used for the diagnosis of early-stageheart failure in children with congenital heart disease PMID: 24899611
    33. Despite, h-FABP was successful to predict 30-days mortality in patients with PE at intermediate risk; it is suggested to be failed in determining the patients who will benefit from thrl therapy. PMID: 24264959
    34. Results show that MDGI is expressed in human brain tumor specimens in a grade-dependent manner and its expression positively correlated with the histologic grade of the tumor, suggesting MDGI as a novel marker for malignant gliomas. PMID: 24493698
    35. Our findings indicate that Abeta-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau PMID: 24088526
    36. the addition of H-FABP significantly enhanced the sensitivity and accuracy of diagnosis as compared to a prior-generation troponin assay alone, especially in patients who presented early PMID: 23328883
    37. Overexpression of FABP3 inhibited cell growth and proliferation via negative regulation of the cell cycle and down-regulation of cell growth factors, but enhances cell survival in hypoxic or ischemic conditions. PMID: 24583397
    38. The H-FABP rapid test provides additional diagnostic certainty in suspected acute coronary syndrome. PMID: 23332896
    39. H-FABP is related to MetS and FAC status in asymptomatic SCI patients. PMID: 23483223
    40. Heart-type fatty acid binding protein (hFABP) and VEGF CSF concentrations distinguished between healthy controls and patients with AD dementia with a sensitivity and specificity of 57 and 35%, and 76 and 84%, respectively PMID: 23591828
    41. Patients with multi-trauma had significantly higher H-FABP concentrations at 24 and 48 h PMID: 23590685
    42. Measurement of heart-type FABP in patients with acute myocardial infarction shows no improvement for early diagnosis compared with sensitive troponin assay. PMID: 22078394
    43. The early stages of Alzheimer's disease and vascular dementia have elevated cerebrospinal fluid levels of FABP protein compared to controls. PMID: 23254629
    44. One-year increases in skin autofluorescence and plasma H-FABP, used separately and in combination, are strong predictors of overall and cardiovascular mortality in hemodyalisis patients. PMID: 23635017
    45. High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support. PMID: 23734811
    46. Elevated serum H-FABP during the convalescent stage of AMI predicted long-term mortality and readmission for HF after survival discharge in the post-AMI patients. PMID: 23291993
    47. plasma h-fabp was correlated with initial stroke score, and was significantly higher in patients with poor clinical outcome PMID: 22766253
    48. The methylation status of FABP3 is associated with phenotypes of metabolic syndrome. PMID: 23510163
    49. study confirmed an association of H-FABP with the pathogenesis of clinical and experimental obesity-related glomerulopathy, and suggests that such a process might be related to podocytes and lipid dysmetabolism PMID: 23029183
    50. investigation of H-FABP as biomarker for metabolic disorders: Data suggest that serum H-FABP levels are higher in subjects with insulin resistance and metabolic syndrome than in subjects without such metabolic disorders regardless of gender. PMID: 23093954

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3557

    OMIM: 134651

    KEGG: hsa:2170

    STRING: 9606.ENSP00000362817

    UniGene: Hs.576372