Human soluble interleukin-1 receptor Ⅱ,IL-1sRⅡ ELISA kit

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

1. The expression of SLC22A4, IL1R2 and VNN3, were independently associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure patients. PMID: 29901123
2. these results reveal that the IL-1/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of ulcerative colitis patients PMID: 26530134
3. Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD. PMID: 27461004
4. present study demonstrated the ability of Staphylococcus aureus to induce IL-1RII shedding in myeloid cells PMID: 26967533
5. Expression level of IL1R2 was down regulated in cervical squamous cell carcinoma. PMID: 28341182
6. reduced risk of preterm birth in Indian women with the minor allele of rs2072476 polymorphism PMID: 26607028
7. No significant differences in the lymphocyte mRNA levels of IL-1R2, IL-6R, and Gp130 were observed between MDD patients and NC. These studies suggest abnormal gene expression of these cytokines and their membrane-bound receptors in the lymphocytes of MDD patients, and that their mRNA expression levels in the lymphocytes could be a useful biomarker for depression. PMID: 27138824
8. IL1R2 rs2310173 genotype GT was mildly protective against ankylosing spontylitis only in HLA-B27-negative patients. PMID: 26590821
9. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea PMID: 26888452
10. This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with ankylosing spondylitis in Northern Han Chinese. PMID: 25736356
11. Suggest IL-1R2 as potential biomarker of acute respiratory distress syndrome. PMID: 25849954
12. Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6, levels were positively correlated with a composite measure of aggression. PMID: 25650410
13. results suggested that IL1R2 could have oncogenic potential in osteosarcoma PMID: 25432697
14. Interleukin-1alpha Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2 PMID: 26324711
15. A genetic susceptibility locus for AgP may lie within or close to the IL1R2 locus in Japanese aggressive periodontitis. PMID: 24818754
16. First study evaluating for associations between cytokine gene variations and the development of persistent breast pain in women following breast cancer surgery: 1 SNP (IL1R2 rs11674595) and 1 haplotype (IL10 haplotype A8) were associated with pain PMID: 24411993
17. Data indicate a significant increase in the levels of IL-8, TNF-alpha and IL-1R2 in the CSF of both meningitis groups as compared to controls, and the concentrations of IFN-gamma and IL-1 differed significantly only between the mumps group and control. PMID: 24313836
18. Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1alpha, controlling necrosis-induced sterile inflammation. PMID: 23395675
19. The methylation statuses of the IL10 and IL1R2 genes were significantly reduced in the SLE patient samples relative to the healthy controls PMID: 22048455
20. ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population. PMID: 20652271
21. interactions between TLR4 and IL-1R2 are associated with cervical pro-inflammatory cytokine concentrations. PMID: 21704385
22. Results suggest that under atherogenic conditions, there is a decrease in IL-1R2 expression in monocytes/macrophages and in the vascular wall that may facilitate IL-1 signaling. PMID: 21683158
23. As already reported in endometriotic cells, endometrioid ovarian cancer cells exhibit a decrease in the expression of IL-1RII. These findings highlight a common signature between endometrioid ovarian cancer and implants of endometriosis. PMID: 21083841
24. reduced levels of mRNA in the endometrium of women suffering from endometriosis reveals a profound defect in gene expression with reduced capability of endometrial tissue to down-regulate IL-1 activity PMID: 11804955
25. the unique sIL1R-II binding ability of human IL-1beta is due to a single amino acid difference compared with monkey IL-1beta PMID: 12356774
26. findings point toward a deficiency in the mechanisms involved in the down-regulation of IL-1 actions at the systemic level and reveal soluble interleukin-1 receptor type II as a key factor involved in that process PMID: 12372465
27. to evaluate whether the interleukin (IL)-1 decoy receptor (R)is correlated with severity of infection in critically ill patients and reflects the activation of anti-inflammatory pathways by glucocorticoid hormones PMID: 12377932
28. soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor PMID: 12530978
29. The type II IL-1 decoy receptor acts as a scavenger of IL-1, representing a novel autoregulatory mechanism of the IL-1 system in neutrophils. PMID: 12794127
30. serum IL-1 alpha and IL-1 soluble receptor type 2 levels in women with ovarian cancers were significantly higher than those in cervical cancer, and in patients with benign disorders, and in healthy control PMID: 14674121
31. a reduced release of sIL-1RII by the endometrial tissue of women with endometriosis and revealed a proteolytic post-translational mechanism which may be involved in the down-regulation of IL-1RII levels PMID: 15705625
32. Increased circulating levels of interleukin 1 receptor, type II is associated with Hepatitis C virus positive patients and with those affected also by non-Hodgkin's lymphoma and cryoglobulinemia syndrome PMID: 16596202
33. These findings reveal that nuclear localization of pre-IL-1alpha depends on the binding to HAX-1 and that biological activities might be elicited by the binding to both HAX-1 and IL-1RII in SSc fibroblasts. PMID: 16971486
34. BACE1 and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP PMID: 17307738
35. decreased IL1R2 expression is predominant in the eutopic and ectopic endometrium of women with endometriosis when compared with normal women. PMID: 17324958
36. Suggest that IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis. PMID: 17482186
37. Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis. PMID: 17517439
38. Chorionic gonadotropin down-regulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells. PMID: 17702847
39. Levels of interleukin-1beta and Il1R2in the peritoneal fluid of normal women and patients with endometriosis suffering from pelvic pain and infertility. PMID: 17919610
40. IL1R2 was greatly decreased with future rejection and FLT3, ITGAM, and PDCD1 showed borderline changes in future cardiac rejections. PMID: 18096476
41. was detected more often in chronic periodontitis gingival crevicular fluid than in aggressive periodontitis gingival crevicular fluid, and there was no correlation between gingival crevicular fluid concentration and clinical parameters. PMID: 18315432
42. Results suggest that interleukin-1 receptor type II overexpression is likely, through activation of the IL-1alpha precursor pathway, to enhance cell migration. PMID: 19026558
43. Alternate splicing of interleukin-1 receptor type II in vitro correlates with clinical glucocorticoid responsiveness in patients with autoimmune inner ear disease. PMID: 19401759
44. IL1R2 showed significant associations with Aspirin-intolerant asthma. PMID: 19489917

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[Isoform Short]: Secreted.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein.

Interleukin-1 receptor family

HGNC: 5994

OMIM: 147811

KEGG: hsa:7850

STRING: 9606.ENSP00000330959

UniGene: Hs.25333