Mouse L-Selectin ELISA kit

1. data suggest that Ly6C(+)CD62L(+) infected monocytes served as a Trojan horse across the cerebral endothelium to induce brain infection. Therefore, CD62L should be considered as not only a temporally elicited antigen but also a disease-relevant leukocyte marker during the development of neurologic melioidosis. PMID: 27646437
2. Myeloid-derived suppressor cell-induced L-selectin loss occurs through a contact-dependent, post-transcriptional mechanism that is independent of the major L-selectin sheddase, ADAM17, but results in significant elevation of circulating L-selectin in tumor-bearing mice. PMID: 27929373
3. CD8(+) T-cells mediate ischemia reperfusion injury in a fatty liver through L-selectin. PMID: 28543181
4. L-selectin is transported constitutively by the AP-1 complex, leading to the formation of a trans-Golgi network reserve pool; phosphorylation of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin PMID: 28235798
5. freeze and thaw of murine and human Tregs is associated with reduced expression of L-selectin (CD62L), which was previously established to be an important factor that contributes to the in vivo protective effects of Tregs PMID: 26693907
6. endothelial colony-forming cells interact with activated neutrophils via PSGL-1 and L-selectin PMID: 24606340
7. These data indicate that L-selectin plays a major role in the development of C protein induced polymyositis, whereas ICAM-1 plays a lesser role, if any. PMID: 24644046
8. Data suggest that modulation of P- and L-selectins may constitute a promising therapeutic approach. PMID: 24177139
9. These results put into question the utility of CD62L as a predictive biomarker for the efficacy of ex vivo-expanded T cells after ACT in lymphopenic conditions. PMID: 24218360
10. The PSGL-1-L-selectin complex-induced signaling effects on neutrophil slow rolling and recruitment in vivo demonstrate the functional importance of this pathway. PMID: 24127491
11. L-selectin-dependent signalling - exploring the different signals that potentially arise from distinct phases of the multi-step adhesion cascade and the contribution of known binding partners of L-selectin in this respon PMID: 23299028
12. CD62L marks a mature natural killer (NK) cell subset by affecting the magnitude of the local NK cell response to adenovirus infection in the liver. PMID: 23509354
13. Data indicate that naive lung CD4 cells supply the draining lymph nodes through a CD62L-independent, CCR7-dependent pathway. PMID: 23319636
14. Signaling induced by ligation of L-selectin using mAb or endothelial cell-expressed ligand significantly enhanced the chemotaxis of murine T cells and B cells to SLC but not to other homeostatic chemokines. PMID: 22387549
15. Pretreatment of cardiac mesoangioblasts with SDF-1 or transient expression of L-selectin induced a two- to three-fold increase in their transmigration and homing to the damaged heart. PMID: 21869829
16. Hematopoietic lineage cells with Sca-1(high) expression and CD62L(neg/low) expression are characterized as multipotent progenitor cells, based on transient engraftment. PMID: 21998453
17. the binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH. PMID: 21982762
18. CD4 T cell co-stimulation with ICOS promotes the down-regulation of CCR7 and CD62L after activation, leading to a reduced return of activated CD4 T cells to the lymph nodes and a more efficient entry into the lungs. PMID: 21421907
19. Data show a mechanism of control of CD62-L expression involving the miRNA let-7b. PMID: 21768364
20. Atherosclerotic plaques did not exhibit any differences in cellular composition assessed by immunohistochemistry for CD68, CD3, CD4, and CD8 in ApoE(-/-)L-sel(-/-) as compared to ApoE(-/-) mice. PMID: 21760899
21. migratory profile of CD62L-/- Tregs was that of an intermediate activated phenotype with higher expression of pro-inflammatory chemokine receptors compared to CD62LHi Tregs and much greater expression of CCR7 compared to CD62LLo Tregs. PMID: 21070606
22. IL-7 drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1, leading to reduced expression of CD62L and the migration of T cells into circulation. PMID: 20831893
23. In cultured cells and in mice, myeloid differentiation (MyD88)-dependent activation of B cells via Toll-like receptor TLR2 or TLR9 causes rapid loss of expression of CD62L by shedding caused by systemic infection with Salmonella typhimurium. PMID: 20660707
24. Study suggests that L-selectin and ICAM-1 regulate Th2 and Th17 cell accumulation into the skin and lung, leading to the development of fibrosis. PMID: 20624949
25. Division-linked differentiation predicts the differences in proportion of cells CD62L(high) observed between responses of different adoptive transfer number and within individual mice. PMID: 19859082
26. lymphoma cells are the major contributors to levels of soluble forms of L-selectins in lymphoma-bearing mice PMID: 20001233
27. Auditory stress enhances contact hypersensitivity (CH) response and that the augmentation of this CH response might be mediated through L-selectin, but not through P- or E-selectin pathways. PMID: 19948832
28. Our data indicate a critical role for CD62L and lymph node homing for the process of homeostatic proliferation PMID: 19658092
29. the role of L-selectin in induction of alloantigen-specific tolerance PMID: 11823485
30. required for recruitment of dendritic cells to lymph nodes during mouse mammary tumor virus infection PMID: 11830477
31. Surprisingly, L-selectin expressed on endogenous leukocytes also facilitates metastasis in both the syngeneic and xenogeneic (T and B lymphocyte deficient) systems PMID: 11854515
32. CD62L expression is not essential for the development of T cell-mediated type 1 diabetes in NOD mice. PMID: 11884430
33. L-selectin contributes to immune complex-induced skin injury cooperatively with ICAM-1 by regulating the accumulation of neutrophils and mast cells. PMID: 11884469
34. L-selectin dimerization enhances tether formation to properly spaced ligand. PMID: 11907045
35. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. PMID: 12093896
36. influences lymphocyte migration in vivo and increased levels present in certain pathologic conditions may adversely affect leukocyte migration PMID: 12165530
37. CD62L expression is necessary for the diabetes-delaying effect of transfer of CD4+CD25+ splenocytes in vivo, but not for their suppressor function in vitro. PMID: 12193715
38. Culture-activated T cells with the CD62 L-selectin(low) phenotype have potent antitumor activity and memory in vitro and in vivo and when adoptively transferred can eliminate advanced pulmonary metastases and cure subcutaneous tumors. PMID: 12218152
39. L-selectin is involved in the P- and E-selectin-independent migration of cytotoxic T lymphocytes into inflamed skin. PMID: 12370362
40. L-selectin regulates pulmonary fibrosis by mediating the accumulation of leukocytes. PMID: 12414509
41. Loss of nasal passage and reproductive tract immunity in L-selectin-deficient mice at 16 days postprimary intranasal immunization with cholera toxin is due to delay of L-selectin(low)/alpha4beta7 integrin (double- low) B cells entering these sites. PMID: 12421944
42. L-selectin cooperatively with ICAM-1 regulates induction of the immediate-type hypersensitivity response by mediating mast cell accumulation into inflammatory sites. PMID: 12682269
43. L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1, targets specific lymphocyte subsets to BALT. PMID: 12756264
44. leukocyte-expressed PSGL-1 serves as the main L-selectin ligand in inflamed postcapillary venules. PMID: 12756271
45. Data suggest that Trousseau syndrome is likely triggered by interactions of circulating carcinoma mucins with leukocyte L-selectin and platelet P-selectin without requiring accompanying thrombin generation. PMID: 12975470
46. L-selectin shedding from antigen-activated T cells prevents reentry into peripheral lymph nodes PMID: 14597735
47. In a chronic ileitis model, pathogenic CD4+ T cells alternatively engage L-selectin in order to recirculate to the chronically inflamed small intestine. PMID: 15699171
48. L-selectin has a role in the growth of thymic lymphoma PMID: 15705798
49. leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands PMID: 15743805
50. preferential migration of CD62L+CD4+ cells into the appendix as compared to the colon PMID: 15905618

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KEGG: mmu:20343

STRING: 10090.ENSMUSP00000027871

UniGene: Mm.1461