Mouse Ornithine carbamoyltransferase, mitochondrial(OTC) ELISA kit
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中文名稱:小鼠鳥氨酸氨甲酰基轉(zhuǎn)移酶,線粒體(OTC)酶聯(lián)免疫試劑盒
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貨號:CSB-EL017270MO
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
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靶點(diǎn)詳情
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功能:Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
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基因功能參考文獻(xiàn):
- Gene correction in adult OTC-deficient mice was lower and accompanied by larger deletions that ablated residual expression from the endogenous OTC gene, leading to diminished protein tolerance and lethal hyperammonemia on a chow diet PMID: 26829317
- The corresponding OTC tissue enzyme activities were between 3-6% of normal control in mouse and human liver. The use of the cryptic splice sites was reproduced in minigenes carrying murine or human mutant sequences PMID: 25853564
- Serum OCT seemed to reflect tumor necrosis factor-alpha-mediated hepatic damage in diabetic obese mice and could be useful in the application for non-alcoholic fatty liver disease with features of metabolic syndrome, such as obesity and diabetes. PMID: 19793175
- in vivo regulation by HNF4alpha PMID: 11994307
- Results highlight the importance of the interaction between the OTC spf-ash mutation (ornithine transcarbamylase deficiency) and genetic backgrounds on metabolic phenotypes (ureagenesis, arginine metabolism, and nitric oxide production). PMID: 17925451
- Phenotypic correction of OTC deficiency using low-dose helper-dependent adenoviral vectors is reported. PMID: 18563850
- Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. PMID: 19318352
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相關(guān)疾?。?/div>Defects in Otc are the cause of the Sparse fur (spf) phenotype. Spf mouse have an OTCase with an overall decrease in activity, and altered substrate affinity.亞細(xì)胞定位:Mitochondrion matrix.蛋白家族:ATCase/OTCase family數(shù)據(jù)庫鏈接:
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