Mouse Sortilin(SORT1) ELISA kit

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

1. this study revealed an important role of insulin signaling in regulating adipose Sort1 protein stability, and further suggests that impaired insulin signaling may underlie reduced adipose Sort1 in obesity. PMID: 28844948
2. Present crystal structures that show the sortilin luminal segment (s-sortilin) undergoes a conformational change and dimerizes at low pH. The conformational change, within all three sortilin luminal domains, provides an altered surface and the dimers sterically shield a large interface while bringing the two s-sortilin C-termini into close proximity. PMID: 29167428
3. Altogether, sortilin defines a pathway required for optimal intracellular mycobacteria control and lung inflammation in vivo. PMID: 27389464
4. findings provide insights into the posttranslational regulation of cytokine production through the posttranscriptional control of sortilin expression by TLR signals. PMID: 27220277
5. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined. PMID: 28498396
6. our findings indicate that sortilin is a beneficial protein for the reduction of amyloid pathology in APP/PS1 mice by promoting APP degradation PMID: 29056359
7. we identify interferon-gamma (IFN-gamma) as the key inflammatory mediator controlling sortilin-1 levels PMID: 28742217
8. Data suggest that sortilin expression in both gastrocnemius and extensor digitorum longus muscle is down-regulated by 17-18h of fasting/food deprivation; pathological levels of high blood glucose, as in streptozotocin-induced diabetes, do not alter sortilin expression in skeletal muscle; sortilin expression is elevated during differentiation of myocyte cell line or in presence of high concentration of glucose. PMID: 27980238
9. By contrast, treatment with dexamethasone, which also induced insulin resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side PMID: 27816451
10. Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations. PMID: 28236654
11. sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase activity and serum IL-6. PMID: 27842214
12. This study demonstrated that Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior. PMID: 27118371
13. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. PMID: 26614389
14. Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas and salivary gland. PMID: 26964886
15. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. PMID: 26950419
16. plays a role in innate immune processes and, thus, not in autoimmune neuroinflammation. PMID: 26566674
17. promotes neutrophil adhesion and recruitment via the promotion of cytoskeletal function downstream of integrin-mediated adhesion PMID: 26566675
18. Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase activity. PMID: 25173968
19. Overexpression of SORT1 was shown to reduce Very-Low-Density Lipoproteins , Triglyceride and Apolipoprotein B secretion in mice. PMID: 26477595
20. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. PMID: 26370502
21. sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis. PMID: 25401472
22. Sort1 may play a role in altered hepatic apoB100 metabolism in insulin-resistant conditions PMID: 25805502
23. sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. PMID: 24928897
24. Sortilin-deficient macrophages had significantly reduced uptake of native LDL ex vivo and reduced foam cell formation in vivo, whereas sortilin overexpression in macrophages resulted in increased LDL uptake and foam cell formation. PMID: 25593281
25. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors. PMID: 24416154
26. Sortilin ectopically expressed in undifferentiated cells was translocated to the plasma membrane regardless of the presence or absence of myc7-Glut4 PMID: 23966466
27. Increased saturated fatty acids downregulate liver Sort1 protein, which may contribute to the development of dyslipidemia in obesity and diabetes. PMID: 23904453
28. sortilin is implicated in APP lysosomal and lipid raft targeting via its carboxyl-terminal F/YXXXXF/Y motif. PMID: 23704887
29. this study suggests that sortilin might be involved in different aspects of neurodegeneration in a complex way, supporting the view that sortilin functions in the CNS are broader than being a co-receptor in proneurotrophin and neurotrophin signaling. PMID: 23313508
30. We demonstrate that loss of PGRN impairs proper neurite outgrowth and branching independent of SORT1 PMID: 22781549
31. our findings identified sortilin as an essential neuronal pathway for APOE-containing lipoproteins in vivo and suggest an intriguing link between amyloid-beta catabolism and pro-neurotrophin signaling converging on this receptor. PMID: 23283348
32. Loss of Sortilin reduced the release of interferon-gamma upon infections and in autoimmune colitis. PMID: 23084031
33. Sortilin is required for toxic action of Abeta oligomers (AbetaOs): extracellular AbetaOs trigger apoptosis, and intraneuronal AbetaOs impair degradation pathways. PMID: 22579764
34. model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation PMID: 22751103
35. role of sortilin in light-dependent photoreceptor degeneration PMID: 22558402
36. Endoplasmic reticulum stress target Atf3 acts at the SORT1 promoter region as a transcriptional repressor. PMID: 22466652
37. the regulation of sortilin shedding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway or to the lysosome, thus modulating the bioavailability of endogenous BDNF. PMID: 21730062
38. Results suggest that proneurotrophin-3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex. PMID: 21261755
39. Results describe the antidepressant effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the neurotensin receptor 3 (NTSR3/Sortilin) and acting through TREK-1 inhibition. PMID: 20405001
40. findings demonstrate a role for sortilin as an anterograde trafficking receptor for Trk and a positive modulator of neurotrophin-induced neuronal survival. PMID: 21102451
41. These results suggest that mouse Vps26b-Vps29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network. PMID: 21040701
42. Sortilin-mediated progranulin endocytosis is likely to play a central role in frontotemporal lobar degeneration. pathophysiology. PMID: 21092856
43. Data show that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100, facilitates the formation and hepatic export of apoB100-containing lipoproteins, and regulates plasma low-density lipoprotein cholesterol. PMID: 20816088
44. Sort1 alters plasma LDL-C and very low-density lipoprotein (VLDL) particle levels by modulating hepatic VLDL secretion PMID: 20686566
45. The trafficking of prosaposin and GM2 activator protein to the lysosome in sertoli cells is dependent on sortilin. PMID: 15236333
46. Activation of type I neurotensin receptor-3 in microglial cells mediates the induction of chemokine and cytokine expression by neurotensin. PMID: 15372498
47. Sortilin is not only essential, but also sufficient for biogenesis of GSVs and acquisition of insulin responsiveness in adipose cells. PMID: 15992544
48. The sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging. PMID: 17934455
49. Sortilin, an essential player in adipocyte and muscle glucose metabolism through the control of GLUT4 localisation, is downregulated in obesity and TNF-alpha is likely to be involved in this defect. PMID: 19219422
50. The authors show that the mammalian p75NTR homologue NRH2 critically regulates the expression of sortilin on the neuronal cell surface and promotes p75NTR and sortilin receptor complex formation, rendering cells responsive to proneurotrophins PMID: 19407813

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Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane; Single-pass type I membrane protein.

VPS10-related sortilin family, SORT1 subfamily

Expressed in the brain, particularly the piriform cortex, the cerebral cortex and the hippocampus.

KEGG: mmu:20661

STRING: 10090.ENSMUSP00000099692

UniGene: Mm.157119