Mouse Thrombospondin-2(THBS2) ELISA kit
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中文名稱:小鼠血小板反應(yīng)蛋白-2(THBS2)酶聯(lián)免疫試劑盒
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貨號:CSB-EL023488MO
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:THBS2(血小板聚集素-2,Thrombospondin-2)與THBS1具有高度相似性,也是一種多域蛋白,在細(xì)胞外基質(zhì)的形成和維持、細(xì)胞凋亡、細(xì)胞增殖等方面發(fā)揮作用。這些蛋白的含量和表達(dá)水平的變化與多種疾病的發(fā)生和發(fā)展密切相關(guān),因此在臨床醫(yī)學(xué)中具有重要意義。華美生物所提供的Mouse Thrombospondin-2(THBS2) ELISA kit屬于ELISA檢測試劑盒,采用雙抗夾心法定量檢測鼠血清、血漿、組織勻漿樣本中的THBS2,其靈敏度為1.56 ng/ml,檢測范圍為6.25 ng/ml-400 ng/ml。
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別名:Thbs2 ELISA Kit; Tsp2 ELISA Kit; Thrombospondin-2 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates.
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檢測范圍:6.25 ng/ml-400 ng/ml.
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靈敏度:1.56 ng/ml.
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Cardiovascular
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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最新研究進(jìn)展:THBS2是一種血小板的富含蛋白質(zhì),已知在多個生物過程中起到重要的作用。最近的研究表明,THBS2在多種癌癥的發(fā)展中發(fā)揮著作用,例如胃癌、乳腺癌、肺癌等。研究表明,THBS2與腫瘤的侵襲、轉(zhuǎn)移和血管新生有關(guān)。
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功能:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
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基因功能參考文獻(xiàn):
- Data provide evidence that TSP2 transcription is suppressed by hypoxia through a mechanism that requires HIF-1alpha. PMID: 28789925
- TWIST2 induces miR-221-3p expression and consequently suppresses its direct target, THBS2, in lymphatic metastasis cervical cancer. PMID: 29242498
- TSP2 deficiency imparted a brittle phenotype on cortical bone. electron microscopy revealed less intensely stained collagen fibrils with altered morphology in the extracellular matrix assembled by osteoblasts on the anterior surface of TSP2-KO femora. PMID: 26272319
- Enhanced levels of TSP-2 in the skin result in reduced susceptibility to chemically-induced skin carcinogenesis. PMID: 24507936
- in the context of osteoblast differentiation, TSP2 promotes the assembly of a type-I collagen-rich matrix by facilitating pro-collagen processing. PMID: 23763373
- The proposed mechanism for the shift in stem cell fate in fracture healing is that increased vascular density and hence oxygen availability in TSP2-null mice regulates differentiation. PMID: 23775935
- The upregulation of TSP-2 mediated by increased oxidative stress contributes to angiogenesis dysfunction in diabetic bone marrow derived angiogenic cells. PMID: 23723366
- TSP2 is a negative regulator of ischemic fracture healing, and in the absence of TSP2 bone regeneration is enhanced. PMID: 23280580
- Using a TSP-2-knockout mouse model and cardiac cell transplantation, we found significantly reduced fibrosis and increased endothelial cell density in the peri-graft region. PMID: 22512900
- the two TSP2 isforms are differentially modulated at injured and noninjured skeletal sites in an animal undergoing fracture healing. PMID: 22362307
- TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis. PMID: 22308237
- astrocyte-derived TSP-2 is critical for the maintenance of physiological MMP-2 and MMP-9 levels during the foreign body response and contributes to the repair of the BBB PMID: 21704005
- Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 PMID: 21949402
- The secreted protein is an autocrine inhibitor of marrow stromal cell proliferation. PMID: 11874233
- Megakaryocytes require this protein for normal platelet formation and function. PMID: 12732502
- Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling PMID: 12861025
- TSP2-null mice provide an animal model to assist in the understanding of the molecular basis of spontaneous, premature softening of the uterine cervix. PMID: 14561659
- Delay in expression of TSP2 and metalloproteinase 2 in the wounds of aged mice could contribute to their impaired rate of wound healing. PMID: 14996433
- CD36 mediates the antiangiogenic effect of thrombospondin-2, which is modulated by histidine-rich glycoprotein PMID: 15748999
- the absence of TSP2 protects against ovariectomy-induced bone loss by two complementary processes: increased formation and decreased resorption. PMID: 15979292
- Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain. PMID: 18682400
- TSP-2 was found to be present in some, but not all, annulus cells of the human annulus and the mouse annulus. PMID: 18718009
- Taken together, our observations support a role for TSP2 as critical determinant of the brain response to biomaterials. PMID: 19020342
- TSP-2 expression in the heart protects against age-dependent dilated cardiomyopathy. PMID: 19805649
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蛋白家族:Thrombospondin family
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