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中文名稱:小鼠胸腺基質(zhì)淋巴細胞生成素(TSLP)酶聯(lián)免疫試劑盒
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貨號:CSB-EL025141MO
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:
CUSABIO's mouse TSLP ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse TSLP in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of TSLP in samples. The color intensity is measured at 450 nm via a microplate reader.
TSLP is a pleiotropic cytokine expressed primarily by epithelial cells at barrier surfaces such as the skin, gut, and lung in response to danger signals. It acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils, and innate lymphoid cells, affecting their maturation, survival, and recruitment. TSLP binds to its receptor (TSLP-R) to exert its biological activities. TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and eosinophilic esophagitis but also to other immune-mediated diseases such as cancer and rheumatoid arthritis.
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別名:Tslp ELISA Kit; Thymic stromal lymphopoietin ELISA Kit; Thymic stroma-derived lymphopoietin ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:15.6 pg/ml-1000 pg/ml
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靈敏度:3.9 pg/ml
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Immunology
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻
- Glycyrrhizic acid suppresses atopic dermatitis‐like symptoms by regulating the immune balance DD Hou,Journal of cosmetic dermatology,2022
- Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection Dai C, et al,Experimental eye research,2019
相關(guān)產(chǎn)品
靶點詳情
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功能:Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
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基因功能參考文獻:
- this paper shows that IL-33 promotes gastrointestinal allergy in a TSLP-independent manner PMID: 28656964
- a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP, and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy. PMID: 29116372
- Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells. PMID: 30011850
- findings suggest a role of TSLP in directly promoting Th2 cell effector function and support the notion of TSLP as a key driver of Th2 PMID: 29339496
- Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. PMID: 26830114
- the pathological mechanisms of particulate matter PM2.5 may be associated with allergic/steroidresistant airway inflammation, Tcell helper (Th)1/Th2 cytokine production and upregulation of TSLP expression in a murine model of allergic and steroid-resistant asthma. PMID: 28765890
- Results suggest combinatorial mechanisms involved in the tissue-selective regulation of thymic stromal lymphopoietin (TSLP) transcription in epidermal keratinocytes and intestinal epithelial cell(s) (IEC). PMID: 28115699
- these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection PMID: 27924821
- blockading the JAK/STAT pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis. PMID: 28214951
- study concludes that IL-33 and TSLP are required for epithelial cell IL-25 expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection PMID: 28701507
- TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin in house dust mite (HDM)-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin and beta-catenin as well as phosphorylation(p)-AKT induced by HDM. In vitro, HDM increased the expression of TSLP and E-cadherin dysfunction by PI3K/Akt signaling pathway. PMID: 28400057
- this study shows that TSLP is a key target of Mi-2beta in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation PMID: 28092372
- These data demonstrate that multiple pathogenic strains of RSV induce IL-13-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection. PMID: 27156176
- the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation. PMID: 26934097
- The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23/type 17 axes. PMID: 26993035
- this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33, IL-25 and TSLP PMID: 27749840
- TNF-alpha and IL-1beta, which are partly produced by LPS-activated leukocytes, contribute to TSLP production via TLR4 activation in vivo. PMID: 27271511
- IL-33-ERK/JNK/p38/Egr-1/TSLP axis involved in allergic skin Th2 inflammation PMID: 26120956
- Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR-Ig improves ALI at least in part by regulation of dendritic cell functions. PMID: 26617780
- TSLP expression in the skin is mediated via RARgamma-RXR pathways. PMID: 26531761
- results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers. PMID: 26927668
- Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice PMID: 26310839
- production by monocyte-derived dendritic cells requires the integration of signals from dectin-1, the IL-1 receptor, and endoplasmic reticulum stress response stress signaling pathways PMID: 26573878
- The short TSLP isoform ameliorates experimental colitis in mice and prevents endotoxin shock. The long TSLP isoform is proinflammatory and is only expressed during inflammation. PMID: 26014813
- Suggest that Treg defects in ApoE(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells and dendritic cells. PMID: 25544178
- expression of, and immune activation by, TSLP contributes significantly to the immunopathology of experimental autoimmune encephalomyelitis. PMID: 25753260
- These results demonstrate a role for TSLP and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions PMID: 25365222
- basophils and TSLP have pivotal roles in Th2 development in the skin during the sensitization phase of food allergy. PMID: 24860117
- Thymic stromal lymphopoietin plays divergent roles in the pathogenesis of atopic and nonatopic asthma phenotypes by either enhancing Th2 responses or curtailing T-helper 17 responses. PMID: 24961817
- TSLP signaling in CD41 T cells is required for not only TH2 memory cell formation in vivo but also the recall response of the memory cells to local antigen challenge. PMID: 25441291
- constitutively expressed by hepatocytes and increased during halothane-induced liver injury PMID: 24723460
- TN DC represent a dermal DC subset that should be considered in future studies of TSLP-dependent contact sensitization and skin immune responses. PMID: 25057004
- Report glyphosphate-rich air samples stimulate airway inflammation via IL-33/TSLP/IL-13 pathways. PMID: 25172162
- TSLP levels peak early but are sustained during the first 48 h of sepsis. PMID: 24990542
- chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process. PMID: 25015831
- Skin Tslp initiates Th2 responses through an orchestrated immune cascade. PMID: 24284909
- plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells. PMID: 24599138
- Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. PMID: 24220317
- Epicutaneous sensitization on a disrupted skin barrier is associated with accumulation of TSLP-elicited basophils, which are necessary and sufficient to promote antigen-induced intestinal food allergy. PMID: 24560412
- promotes mutualistic T-cell responses following intestinal bacterial colonization PMID: 23515135
- RG1 has the inhibitory effect of TSLP production and caspase-1 activity in AR experimental model. PMID: 24053327
- The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR). PMID: 24632570
- These results suggest that Nickel allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells PMID: 24670797
- TSLP stimulation can induce cellular senescence during airway remodeling in asthma. Inhibiting the signaling pathways of cellular senescence overcomes TSLP-induced airway remodeling PMID: 24167583
- These results indicate that the progesterone suppresses Th17 cell responses, and enhances the development of Treg cells, through TSLP-dependent mechanisms, and play a role in female asymptomatic gonococcal infections. PMID: 23835188
- these data suggest that TSLP uniquely participates in local immunity in the respiratory tract and modulation of TSLP levels may promote long-term CD8 T cell immunity in the mucosa when other prosurvival signals are limiting. PMID: 24489089
- Report mouse cell line producing high levels of TSLP which can be used in high-throughput screening for anti-allergy agents. PMID: 24252242
- TSLP expression is enhanced by the absence of microbiota in mice with defective skin barriers PMID: 23698100
- Findings show that keratinocyte-derived TSLP activates sensory neurons directly to evoke itch behaviors. PMID: 24094650
- TSLP expression in CCR2-/- mice may contribute to the propensity of these mice to develop exaggerated Th2-type immune responses PMID: 23472158
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亞細胞定位:Secreted.
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