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中文名稱:小鼠促卵泡素(FSH)酶聯(lián)免疫試劑盒
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貨號:CSB-E06871m
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規(guī)格:96T/48T
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價格:¥3200/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:FSH (卵泡刺激素,F(xiàn)ollicle-stimulating hormone) FSH是一種由腦下垂體前葉分泌的激素,主要作用于生殖系統(tǒng),促進雌性卵巢和雄性睪丸的發(fā)育和功能,調(diào)節(jié)雌、雄激素的合成和分泌。在女性中,F(xiàn)SH參與卵泡的發(fā)育和成熟,促進卵巢中孕激素和雌激素的分泌。在男性中,F(xiàn)SH則促進精子的生產(chǎn)和分泌。臨床上,F(xiàn)SH是評估生殖系統(tǒng)功能的重要指標,如不孕癥、性早熟、性腺功能減退等疾病。華美生物所提供的Mouse follicle-stimulating hormone,FSH ELISA Kit屬于ELISA檢測試劑盒,采用競爭法定量檢測鼠血清、血漿樣本中的FSH,其靈敏度為2.5 mIU/ml,檢測范圍為4 mIU/ml-140 mIU/ml。
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別名:FshbFollitropin subunit beta ELISA Kit; Follicle-stimulating hormone beta subunit ELISA Kit; FSH-B ELISA Kit; FSH-beta ELISA Kit; Follitropin beta chain ELISA Kit
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縮寫:FSH
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma
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檢測范圍:4 mIU/ml-140 mIU/ml
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靈敏度:2.5 mIU/ml
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Signal Transduction
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測定原理:quantitative
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測定方法:Competitive
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻
- The epithelial Na+ channel (ENaC) in ovarian granulosa cells modulates Ca2+ mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility X Ma, R Xu, J Chen, S Wang, P Hu, Y Wu,Cell Communication and Signaling,2024
- The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model hanqing hong, C Xiao, lichun Weng, Q Wang, D Lai,bioRxiv,2024
- Excessive free fatty acid sensing in pituitary lactotrophs elicits steatotic liver disease by decreasing prolactin levels X Ji,Cell reports,2024
- Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice Y Yokota,Journal of gastroenterology,2023
- Effects of Perilla frutescens Var. Acuta in Busulfan-Induced Spermatogenesis Dysfunction Mouse Model HJ Nam,The world journal of men's health,2024
- Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production J Xu,International journal of molecular sciences,2023
- Ovary-derived Decellularized Extracellular Matrix-based Bioink for Fabricating 3D Primary Ovarian Cells-laden Structures for Mouse Ovarian Failure Correction J Zheng,International Journal of Bioprinting,2023
- Preventive effect of swim bladder hydrolysates on cyclophosphamide‐induced ovarian injury in mice E Ge,journal of obstetrics and gynaecology research,2023
- Selenium mitigates methotrexate‐induced testicular injury: Insights from male NMRI mice model Y Zeng,Birth defects research,2024
- Chlorophytum borivilianum aqueous root extract prevents deterioration of testicular function in mice and preserves human sperm function in hydrogen peroxide (H2O2)-induced oxidative stress S Mararajah,Journal of ethnopharmacology,2023
- Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice L Kong,Food Science and Human Wellness,2023
- Human Pluripotent Stem Cell–Mesenchymal Stem Cell-Derived Exosomes Promote Ovarian Granulosa Cell Proliferation and Attenuate Cell Apoptosis Induced by Cyclophosphamide in a POI-like Mouse Model L Zhang,Molecules,2023
- Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics Y Gao,GeroScience,2023
- Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice W Chen,International Journal of Molecular Sciences,2023
- Hyponatremia-related liver steatofibrosis and impaired spermatogenesis: evidence from a mouse model of the syndrome of inappropriate antidiuresis G Marroncini,Journal of endocrinological investigation,2022
- High Housing Density-Induced Chronic Stress Diminishes Ovarian Reserve via Granulosa Cell Apoptosis by Angiotensin II Overexpression in Mice J Kim,International journal of molecular sciences,2022
- A Docosahexaenoic Acid Derivative (N-Benzyl Docosahexaenamide) as a Potential Therapeutic Candidate for Treatment of Ovarian Injury in the Mouse Model L Guo,Molecules,2022
- FSH blockade improves cognition in mice with Alzheimer's disease Jing Xiong,Nature,2022
- Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice Dacheng Yang,Journal of Hazardous Materials,2022
- Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice Dacheng Yang,Journal of Hazardous Materials,2021
- In Situ Gene Therapy Rescues Doxorubicin-induced Ovarian Damage via Adenovirus Mediated Sirt1 and Tgfbr2 L Ma,Research Square,2021
- Bioinformatic and mouse model reveal the potential high vulnerability of Leydig cells on SARS-CoV-2 J Zhang,Annals of Translational Medicine,2021
- Samul-tang ameliorates oocyte damage due to cyclophosphamide-induced chronic ovarian dysfunction in mice J Kim,Scientific reports,2020
- Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice M Li,Chinese Medicine,2020
- Lung cancer aggressiveness in an intermittent hypoxia murine model of postmenopausal sleep apnea M Torres,Menopause,2020
- Protective effects of selenium on malathion-induced testicular toxicity in mice MA Ibrahim,Indian Journal of Animal Research,2020
- A novel follicle-stimulating hormone vaccine for controlling fat accumulation X Han,Theriogenology,2020
- Receptor Binding Inhibitor Suppresses Carcinogenesis of Cervical Cancer by Depressing Levels of FSHR and ERβ in Mice Gong Z,Anti-Cancer Agents in Medicinal Chemistry,2019
- Hydroxysafflor yellow A exerts beneficial effects via restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice Luo M, et al,Experimental Physiology,2019
- The antioxidant curcumin postpones ovarian aging in young and middle-aged mice Saeideh Hasani Azami, et al,Reproduction, Fertility and Development,2019
- Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice Z Yang, et al,Stem Cell Research & Therapy,2019
- FSH receptor binding inhibitor restrains ovarian cancer through down-regulating expression levels of FSHR and ERβ in mice Zhuandi G, et al,Gene,2018
- Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice Jiao Luo .et al,EBioMedicine,2018
- Determine the Role of FSH Receptor Binding Inhibitor in Regulating Ovarian Follicles Development and Expression of FSHR and ERα in Mice Luju Lai.et al,BioMed Research International,2018
- Lycopene reduces in utero bisphenol A exposure-induced mortality, benefits hormones, and development of reproductive organs in offspring mice Shuang Ma.et al,Environmental Science and Pollution Research,2018
- Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner Koichi Yabiku.et al,BMC Endocrine Disorders,2018
- Genotoxic and Hypogonadism Effect of Triclosan Treatment and the Mitigating Effect of Vitamin E in Male Albino Mice Nahed A Hussien.et al,Journal of Basic and Clinical Pharmacy,/
- Bisphenol A Exposure during Pregnancy Alters the Mortality and Levels of Reproductive Hormones and Genes in Offspring Mice Ma S.et al,Biomed Res Int.,2017
- Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway. Xia T.et al,J Assist Reprod Genet.,2016
- Development and Characterization of Cell-Specific Androgen Receptor Knockout Mice O??ara L.et al,The Nuclear Receptor Superfamily: Methods and Protocols,2016
- Inhibin a-Subunit N-terminus Interacts With Activin Type IB receptor To Disrupt Activin Signaling Zhu J et al,The Journal of Biological Chemistry,2012
相關(guān)產(chǎn)品
靶點詳情
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最新研究進展:促性腺激素(FSH)是一種調(diào)節(jié)性蛋白質(zhì),主要在垂體前葉合成并分泌。FSH對于正常生殖功能是非常重要的,它能促進睪丸和卵巢的發(fā)育和功能,并且參與了性激素的合成和分泌。目前的研究表明,F(xiàn)SH不僅在生殖系統(tǒng)中發(fā)揮作用,在其他組織和器官中也有生物學意義。例如,F(xiàn)SH對于骨代謝、血糖調(diào)節(jié)等方面都有影響。
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功能:Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
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基因功能參考文獻:
- FSH induces autophagy via upregulation of HIF-1A in mouse granulosa cells. PMID: 28817115
- the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated. PMID: 27561202
- These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice. PMID: 27101301
- GnRH stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb gene induction. PMID: 27466366
- Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males. PMID: 26789235
- GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway. PMID: 25635942
- results suggest that FOXO1 binding to the proximal Fshb promoter as well as FOXO1 interaction with SMAD3/4 proteins may result in decreased activin induction of Fshb in gonadotropes PMID: 25423188
- SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
- Data suggest that the BMP2-like Activin A/BMP2 chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A signaling. PMID: 25100748
- Two regions of the proximal Fshb promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 suppression of GnRH-induced Fshb transcription. PMID: 24065703
- Data suggest BMP2 (bone morphogenetic protein 2) stimulates SMAD2/3 signaling in gonadotrophs via Bmpr1a (bone morphogenetic protein receptor type 1A); such signaling via SMAD3 appears to be necessary for up-regulation of Fshb transcription. PMID: 24601881
- The activin A signals via SMAD proteins, but not TAK1 or p38, to regulate murine and ovine Fshb transcription in gonadotrope-like cells. PMID: 22549017
- The insulin/IGF signaling pathway is required for FSH-mediated Sertoli cell proliferation. PMID: 23518924
- FOXL2 is required for FSH synthesis in vivo. PMID: 23340250
- Data indicate that free fatty acids up-regulated luteinizing hormone beta (Lhb) mRNA expression acutely but suppressed follicle stimulating hormone beta (Fshb) mRNA expression. PMID: 23525221
- Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. PMID: 22908268
- Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents. PMID: 22294749
- the pituitary gonadotrope contains an ultra-short, activin-responsive feedback loop utilizing two different isoforms of Smad3, one which acts as an agonist and another that acts as an intracrine antagonist to regulate FSH-beta production. PMID: 21664424
- These data indicate that, in addition to its role in the ovary, FoxL2 function in the pituitary is required for normal expression of FSH. PMID: 21700720
- SMADs and FOXL2 synergistically regulate murine follicle stimulating hormone beta transcription via a conserved proximal promoter element PMID: 21622537
- The LIM-homeodomain transcription factor Isl-1 functions to increase FSHbeta/LHbeta gene transcription, and mediates the effects of leptin on gonadotropin synthesis. PMID: 20702576
- It was shown that SMAD4 has a necessary role in activin A induction of the murine FSHb gene in immortalized gonadotropes. PMID: 20371653
- FoxL2 plays a key role in activin induction of the FSHbeta gene, by binding to sites conserved across multiple species. PMID: 20233786
- FSH promotes primordial follicle formation in mice by stimulating local activin signaling pathways and the expression of oocyte-specific transcription factors. PMID: 19641178
- suggest that inducible cAMP early repressor production antagonizes the stimulatory action of cyclic AMP response element binding protein to attenuate FSH beta transcription at high gonadotropin-releasing hormone pulse frequencies. PMID: 20008557
- GnRH regulation of the FSHbeta gene occurs through induction of multiple Fos and Jun isoforms. PMID: 14570911
- Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression. PMID: 14654247
- activins use both SMAD2- and SMAD3-dependent mechanisms to stimulate FSHbeta transcription in mouse gonadotrope cells. PMID: 14701940
- androgens, glucocorticoids, and progestins act via their receptors to directly activate FSHbeta gene expression in the pituitary gonadotrope PMID: 16675544
- Hypogonadal bone loss is caused, at least in part, by enhanced FSH secretion, which in turn increases TNFalpha production to expand the number of bone marrow osteoclast precursors. PMID: 17003115
- Synergistic interaction between activin and glucocorticoids within gonadotrope cell. This synergy can occur directly at level of mouse FSHbeta promoter. PMID: 17082263
- Results show that GnRH overcomes histone deacetylase (HDAC)-mediated repression of the FSH and LH beta-subunit genes in immature gonadotropes. PMID: 17371839
- Steroid receptors physically interact with Smads and are sufficient for the synergism to occur on the FSHbeta promoter. PMID: 18079204
- The knockdown of PRPF19 or EIF4A3 decreased splicing of Lhb, or of both beta subunit transcripts, respectively. PMID: 18480465
- Bone morphogenetic protein 2 signals via BMPR1A to regulate murine follicle-stimulating hormone beta subunit transcription. PMID: 19211807
- study concludes that the rapid effect of GNRH1 on Fshb expression in LbetaT2 cells is mediated by PGR phosphorylation and loading at the PGR response element within the Fshb promoter together with NCOA3 PMID: 19357364
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亞細胞定位:Secreted.
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蛋白家族:Glycoprotein hormones subunit beta family
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