Rat Muscarinic acetylcholine receptor M1(CHRM1) ELISA kit
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中文名稱(chēng):大鼠蕈毒堿型乙酰膽堿受體M1(CHRM1)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-EL005381RA
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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別名:Chrm1 ELISA kit; Chrm-1Muscarinic acetylcholine receptor M1 ELISA kit
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縮寫(xiě):
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類(lèi)型:serum, plasma, tissue homogenates, cell lysates.
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檢測(cè)范圍:0.27 ng/ml- 200ng/ml
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靈敏度:0.27 ng/ml
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Others
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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線性度:
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Effect of the Biofield Energy Treated Proprietary Test Formulation for Sleep Biomarkers in the Unpredictable Chronic Stress (UCS) Animal Model UCSUCSA Model - jndc-chemistryarticles.info,/,2023
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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基因功能參考文獻(xiàn):
- PKC delta activation modulates neurotrophins levels by a signaling pathway that involves M1R activation and ultimately leading to an increase in retinal ganglion cells survival in vitro. PMID: 29705702
- Results establish an intracellular pathway linking M1 receptors, inositol triphosphate receptors, and ubiquitin proteasome system activity to object memory destabilization and suggest a previously unacknowledged role for cholinergic signaling in long-term memory modification and storage. PMID: 29030298
- Study examined the expression of M1 muscarinic ACh receptors in the hippocampus at 7 and 30 days following experimental bilateral vestibular lesions (BVL) in rats using autoradiography. Analysis of the brain tissue revealed a significant reduction in the number of M1 receptors throughout the hippocampus and striatum at 30 days but not at 7 days following BVL. PMID: 27569857
- M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product. PMID: 26626425
- Our results suggest that the mechanism for the deficits in learning and memory of rats with chronic fluorosis may be associated with the decreased expressions of M1 and M3 in mAChRs PMID: 25417050
- Neonatal hypoglycemia decreased total muscarinic receptors (p < 0.001) with reduced muscarinic M1, M2, and M3 receptor genes (p < 0.001) in one month old rats. PMID: 25474381
- M1 cholinergic receptor activation in the central nervous system can modulate endotoxin tolerance in rat liver PMID: 25008070
- Selective M1 and M4 receptor activation each improved memory. PMID: 24480931
- Blockade of M1-cholinoreceptors does not prevent the inhibitory effect of carbacholine on contractility of the atrial and ventricular myocardium. PMID: 24288746
- M1 mAChR may have a role (via the PKC-ERK1/2 pathway) in the neuroprotective effects of lesatropane PMID: 23988164
- The results of this study findings suggested that M1R mechanisms in the BLa are complex, involving postsynaptic effects as well as regulating release of neurotransmitters from presynaptic terminals. PMID: 23559406
- There is a significant decrease in muscarinic M1 receptors in the brain stem following spinal cord injury. PMID: 23184186
- M1-mAChRs function at both surface and intracellular sites in telencephalon neurons including the hippocampus PMID: 23678982
- Muscarinic receptor expression is developmentally regulated; M1, M3, and M4 receptors are the main subtypes expressed in oligodendrocyte progenitor cells. PMID: 21913336
- Report therapeutic potential of the M(1) receptor positive allosteric modulator BQCA for the treatment of memory deficits observed in Alzheimer's disease. PMID: 23085025
- Data suggest that Chrm1 is down-regulated in cell membranes of parotid glands in a model of periodontitis and participates in potassium release; Chrm1 expression appears to return to control level upon indomethacin treatment of periodontitis. PMID: 22513211
- Muscarinic receptor activation determines the downstream effects of store-operated Ca(2+)-entry on neuronal membrane excitability and energy metabolism. PMID: 22088219
- Expression of muscarinic receptor M1, M3, M5 subunits decreased in the flocculus after unilateral labyrinthectomy. PMID: 19160866
- Use of scannning mutagenesis uncovers helix 8 of the M1 mAChR, and a G protein recognition site is delineated in the activated state of the receptor. PMID: 21247934
- study showed that M and M receptors, IP3 and cGMP were functionally regulated during diabetes as function of age PMID: 21054404
- These data indicate a novel mechanism of synaptic plasticity in which activation of M1 receptors results in AMPA receptor endocytosis, via a mechanism involving interactions between GluA2, GRIP and liprin-alpha. PMID: 19534762
- Chrm1 receptor is located on presynaptic glutamatergic terminals afferent to the recorded pyramidal neuron, thus decreasing glutamate release. PMID: 20600670
- muscarinic M(1) receptor showed a significant decrease and muscarinic M(3) receptor subtype showed a significant increased binding in the cerebral cortex of hypoglycemic rats compared to diabetic and control PMID: 21126518
- Cholinergic activation through M(1)-like receptor enhances basket-cell activity & promotes the generation of nested theta & gamma rhythms, enhancing hippocampal function and associated performance. PMID: 20433901
- Thus, the current study identifies ASIC1a as a novel target for muscarinic signaling. PMID: 19730136
- Acetylcholine through muscarinic M1 and M3 receptors stimulated calcium release from the pancreatic islets. PMID: 19554469
- The results indicate that muscarinic M(1) modulation of Ca(V)2.1 Ca(2+) channels in these neurons involves phosphoinositide hydrolysis. PMID: 19883739
- Results highlight long-term low dose somatotropin and insulin treatment in regulating muscarinic M1 and M3 cholinergic and NMAR1 and mGluR5 glutamate receptor subtypes in aging rats and rejuvenation of brain function. PMID: 19666081
- no change on muscarinicM1 mRNA expression was found in the hippocampus of isolation reared rats PMID: 12384226
- In the neuromuscular junction, the modulation of Ach release via M1 and M2 muscarinic autoreceptors differs between the developing and adult rat PMID: 12534975
- This represents the first demonstration of M1 receptors on neuronal progenitor cells and supports the notion that M1 muscarinic receptors may play a role in development of the nervous system PMID: 14675151
- muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production is augmented by synaptic activity to facilitate Ca2+ release in hippocampal neurons PMID: 15342646
- central muscarinic M1 and M3 receptor subtypes functional balance is suggested to regulate sympathetic and parasympathetic activity, which in turn control the islet cell proliferation and glucose homeostasis PMID: 15350825
- M1 mAChR stimulation leads to GSK-3beta inactivation. Cross-talk between muscarinic signaling and Wnt components underlie neuroprotective effect of M1 mAChR activation. PMID: 15474371
- endogenous GRK2 is a key regulator of M1 mACh receptor signaling in hippocampal neurons PMID: 15743771
- Stimulation of M1 muscarinic acetylcholine receptors activates endogenous transient receptor potential-canonical subtype 6 (TRPC6) channels in neuronal PC12D cells. PMID: 15994335
- KCNQ channel currents in striatal medium spiny neurons were potently reduced by M1 muscarinic receptors. PMID: 16093396
- ductules and epididymis suggests that these receptors play a role in the modulation of luminal fluid composition and smooth muscle contraction. PMID: 16160857
- study shows that infection with low numbers of Hymenolepis diminuta leads to modulation of the cholinergic components of the myenteric plexus & M2 receptor mRNA & that large number of worms result in suppression in relative expression of M1 receptor mRNA PMID: 16541262
- results show that the dicyclomine did not affect IA and CFC consolidation, suggesting specific involvement of M1 muscarinic receptor only in acquisition these tasks, and these effects was not state-dependent PMID: 16647280
- Data suggest that acetylcholine acting on M1 and M2 acetylcholine receptors may contribute to selective excitability enhancement or depression in individual, rostrally projecting sensory neurons. PMID: 16820015
- Ach agonists inhibit the non-quantal secretion of ACh from motor nerve terminals by acting on post-synaptic M1 receptors coupled to Ca(2+) channels in the sarcolemma to induce sarcoplasmic Ca(2+)-dependent synthesis and the release of NO. PMID: 17561934
- The findings suggest that activation of M1-type muscarinic cholinergic receptors in the dorsomedial striatum facilitate the flexible shifting of response patterns by maintaining or learning a new choice pattern once selected. PMID: 17709264
- Four derivatives (5a-5c and 5e) showed considerable M1 receptor binding affinity (in vitro) and elicited beneficial effects in vivo memory and learning models (Rodent memory evaluation, plus and Y maze studies). PMID: 17719699
- Study suggests that formation of a direct hydrogen bond between the highly conserved side chains of Asp71 and Asn414 may be a critical feature stabilizing the activated state of the M1 muscarinic acetylcholine receptor. PMID: 17823120
- Taken together these data suggest that the level of synaptic activity may determine the different kinases recruited to regulate M1 mACh receptor desensitization in neurons. PMID: 17908240
- insulin modulates binding parameters and gene expression of total and muscarinic M1 receptors. PMID: 17960828
- Data show that L- and N-type calcium channel current, but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. PMID: 18247369
- These results provide further evidence of the expression of the M(1) muscarinic receptor subtype in the rat heart PMID: 18443764
- Data suggest that 77-LH-28-1 is a potent, selective, bioavailable and brain-penetrant agonist at the M1 mAChR. PMID: 18454168
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM1 sub-subfamily
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