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  4. Rat Retinol binding protein 4,RBP-4 ELISA Kit

Rat Retinol binding protein 4,RBP-4 ELISA Kit

  • 中文名稱：
    大鼠視黃醇結(jié)合蛋白4(RBP-4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09424r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
        RBP4（全稱Retinol-binding protein 4）是一種負(fù)責(zé)維生素A轉(zhuǎn)運(yùn)和代謝的血清蛋白，主要由肝臟合成。其含量水平與多種疾病相關(guān)，如糖尿病、肥胖、代謝綜合征等。研究表明，RBP4可影響胰島素抵抗、葡萄糖代謝以及脂肪代謝等生理過(guò)程，因此被認(rèn)為是一種潛在的治療靶點(diǎn)。
        華美生物所提供的Rat Retinol binding protein 4,RBP-4 ELISA Kit屬于ELISA檢測(cè)試劑盒，采用競(jìng)爭(zhēng)法定量檢測(cè)大鼠血清、血漿、組織勻漿樣本中的RBP4，其靈敏度為39 ng/ml.，檢測(cè)范圍為39 ng/ml-2500 ng/ml.。
     
  • 別名：
    Rbp4 ELISA Kit; Retinol-binding protein 4 ELISA Kit; Plasma retinol-binding protein ELISA Kit; PRBP ELISA Kit; RBP ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
  • 檢測(cè)范圍：
  • 靈敏度：
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    RBP4是一種在維生素A代謝中起關(guān)鍵作用的蛋白質(zhì)，但它也與一些代謝性疾病如肥胖、糖尿病和代謝綜合征等有關(guān)。一些最新的研究表明，RBP4可能作為這些疾病的潛在生物標(biāo)志物和治療靶點(diǎn)，有望為相關(guān)疾病的治療提供新的思路和策略。
  • 功能：
    Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
  • 基因功能參考文獻(xiàn)：
    1. RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
    2. plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
    3. Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
    4. Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
    5. Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
    6. RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
    7. Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 組織特異性：
    Detected in blood plasma (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：