Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active)
In Stock-
中文名稱:小鼠Fgf2重組蛋白
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貨號(hào):CSB-AP004061MO
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規(guī)格:¥576
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圖片:
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其他:
產(chǎn)品詳情
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純度:Greater than 95% as determined by SDS-PAGE.
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內(nèi)毒素:Less than 0.01 EU/μg as determined by LAL method.
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生物活性:The ED50 as determined in a cell proliferation assay using BALB/c 3T3 cells is 0.3-1.8 ng/ml.
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基因名:
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Uniprot No.:
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別名:Fgf2; Fgf-2Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
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種屬:Mus musculus (Mouse)
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蛋白長(zhǎng)度:Full Length
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來源:E.coli
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分子量:17.15 kDa
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表達(dá)區(qū)域:1-154aa
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氨基酸序列MAASGITSLPALPEDGGAAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
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蛋白標(biāo)簽:Tag-Free
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產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:Lyophilized from a 0.2 μm filtered solution of 20mM PB, 400mM NaCl, 0.02% Tween 80, 4.0% Sucrose, 4.0% Manntiol, pH 7.0
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儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
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基因功能參考文獻(xiàn):
- expressed in tissues of the female reproductive tract; affects sperm motility and acrosomal exocytosis PMID: 29866768
- present study highlights the central role for FGF-2 in the progression and maintenance of newly acquired blood and lymphatic vessels in the cornea of HSV-1-infected mice in the absence of infectious virions PMID: 28378806
- NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice. PMID: 28944834
- Knockout of the 18-kDa FGF-2 isoform significantly attenuated atherogenesis, reduced aortic plaques, reduced macrophage infiltration and suppressed oxidative stress in mice fed with a high fat diet at all-time points. PMID: 29466783
- Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis. PMID: 29305908
- FGF2 signaling can regulate osteoblastic niche cells to support HSC homeostasis in response to bone marrow damage PMID: 28662672
- Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signaling. PMID: 27496348
- altered glycosaminoglycans (GAG) distribution in mucopolysaccharidoses I (MPS I) chondrocytes, and altered GAG, FGF2 and Indian hedgehog distribution in growth plates from MPS I mice, is reported. PMID: 27105565
- Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling. PMID: 28452589
- tissue engineered periosteum can deliver FGF-2, TGF-beta1, and ASCs to a mouse critical-sized femur defect and further optimization may yield improved bone allograft healing. PMID: 27874253
- Thus, FGF-2 levels in hESCs culture systems can be manipulated to generate cells with longer telomere which would be advantageous in the applications of hESCs in regenerative medicine. PMID: 27757766
- Low FGF2 expression is associated with cardiac ischemia and systolic dysfunction. PMID: 28771625
- Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB. PMID: 27725190
- data suggest that FGF2 levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2, and FGFR3. PMID: 27133954
- The differentiation of ERF-overexpressing trophoblast stem cell lines also suggests that ERF may have an FGF2-independent effect during the commitment towards syncytiotrophoblasts. PMID: 28244611
- Novel VF-Trap fusion protein on blockage of VEGF and FGF-2 activity to prevent angiogenesis. PMID: 27130666
- FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation PMID: 27404388
- These results support that controlling the aberrant expression of TGF-beta1 and FGF-2 via inhibition of Wnt/beta-catenin signaling could serve as a potential therapeutic strategy for pulmonary fibrosis. PMID: 27112840
- (125)I-bFGF mAb inhibits growth of experimental hepatocellular carcinomas. PMID: 27275095
- In vivo, GSPP treatment (200 mg/kg/d) not only inhibited the growth of colon carcinoma, but also inhibited the tumor lymphangiogenesis. Conclusion. GSPP possesses the antitumor ability by inhibiting bFGF-inducing lymphangiogenesis in vitro and in vivo, which may further inhibit tumor lymphatic metastasis. PMID: 27190997
- The present study indicates that a broad array of genes associated with functions of the cytoskeleton is significantly dysregulated in the MSC cortex of FGF-2 knockout mice PMID: 26970009
- Lack of fibroblast growth factor-2 results in an increased volume of the striatal target area in mice. PMID: 26642808
- Low RICTOR expression was detected in quiescent, confluent mouse aortic endothelial cells, whereas high doses of FGF2 induced high RICTOR expression that was associated with strong mTORC2-specific protein kinase Ca and AKT phosphorylation PMID: 26635098
- Endogenous FGF2 secreted by trophoectoderm cells regulates protein expression and distribution in trophectoderm cells via FGFR2. PMID: 26378412
- IL-1beta promotes FGF-2 expression in chondrocytes PMID: 26811540
- FGF2 monoclonal antibody inhibited angiogenesis B16-F10 metastatic melanoma model. PMID: 26655277
- Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha. PMID: 25975959
- These results demonstrated that recombinant human endostatin could in-hibit tumor metastasis by inhibition of the expression of c-Myc and bFGF in gastric cancer tissue as well as by inhibition of angiogenesis PMID: 26125720
- Cytosolic LMW FGF2 functions as a negative regulator in RIG-I-mediated antiviral signaling. PMID: 26466960
- Data show that, depending of its concentration, FGF2 can be either a positive or negative factor of adipogenesis by regulating the ERK signaling pathway providing a mechanistic basis for FGF2 roles in adipogenesis and development of fat tissues. PMID: 25790378
- Trans-regulation of oligodendrocyte myelination by neurons through Arf6-regulated secretion of fibroblast growth factor-2. PMID: 25144208
- Data indicate that microbiota-driven fibroblast growth factor 2 (FGF2) and interleukin-17 (IL-17) cooperate to repair the damaged intestinal epithelium. PMID: 26320657
- suggest that CD44-positive cells might be a source of cerebellar oligodendrocytes and that FGF-2 plays important roles in their development at an early postnatal stage PMID: 26079890
- This study reveals a novel role for the ERK5-MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts. PMID: 26032256
- Astrocyte-derived bFGF is required for regulation of dopaminergic neurons differentiation of the stem cells and may provide a strategy targeting astrocytes for treatment of Parkinson's disease. PMID: 25517983
- both bone morphogenetic protein and Wnt pathways may be involved in mediating the effects of fibroblast growth factor 2 on dental pulp cells PMID: 25158181
- FGF2 isoforms modulate bone and phosphate homeostasis via multiple pathways related to bone formation, osteoblast differentiation, and Wnt and Fgf2 signaling. PMID: 25389287
- Endostar might exert its anti-tumor effect via suppressing b-FGF-induced angiogenesis and b-FGF-activated MAPK signaling pathway. PMID: 25597785
- Basic FGF stimulated mesenchymal stem cell proliferation is NF-kappaB pathway dependent. PMID: 25065316
- FGF2 acts as a protective growth factor after lung epithelial injury, and call into question the role of FGF2 as a profibrotic growth factor in vivo. PMID: 24988442
- The augmentation of FGF2 expression and reduced optokinetic responses during the resolution of surface vasculopathy may indicate a role for FGF2 in the maintenance of neuroretinal function in OIR/ROP. PMID: 25525167
- These studies demonstrate a feedback loop between Klotho depletion and FGF2 activation in renal fibrosis. PMID: 25130652
- These findings indicate that the lens epithelium of MCT mice has increased expression of TGFbeta before cataract affection and that changes in the expression of FGF2 as well as TGFbeta may contribute to the progression of the cataract in the mice. PMID: 24279395
- FGF2 regulates lymphatic endothelial cell -specific gene expression and suppresses TGFB1 signalling through Smad2. PMID: 24357720
- Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF. PMID: 23918206
- 131 FGF2-regulated miRNAs during lens fiber cell differentiation PMID: 24142921
- In this model the S-domains at the non-reducing ends of the two HS proteoglycan chains are proposed to interact with the FGF2-FGFR2 protein complex. PMID: 24563485
- Data suggest that Fgf2-Fgfr2 (fibroblast growth factor 2/fibroblast growth factor receptor 2) signal cascade is involved in stimulating cell proliferation in prostate basal epithelium in absence of androgen replacement therapy following castration. PMID: 23946540
- Therefore, constitutive deletion of Fgf2 or Fgfr1 knockdown in oligodendrocyte lineage cells is sufficient to overcome impairment of sensorimotor coordination after cuprizone demyelination. PMID: 23684572
- expression of Mll-Ell in myeloid progenitor cells resulted in autocrine production of Fgf2 and Fgf2-dependent cytokine hypersensitivity. PMID: 24089521
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亞細(xì)胞定位:Secreted. Nucleus.
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蛋白家族:Heparin-binding growth factors family
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