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ACTG2 Antibody

  • 中文名稱：
    ACTG2兔多克隆抗體
  • 貨號：
    CSB-PA12799A0Rb
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: ACTG2 antibody at 3µg/ml + CEM whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42, 38 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA12799A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA12799A0Rb at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ACTG2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ACT antibody; ACTA3 antibody; ACTE antibody; ACTG2 antibody; ACTH_HUMAN antibody; Actin antibody; Actin gamma 2 smooth muscle enteric antibody; Actin gamma enteric smooth muscle antibody; Actin like protein antibody; ACTL3 antibody; ACTSG antibody; Alpha actin 3 antibody; Alpha-actin-3 antibody; Gamma 2 actin antibody; Gamma-2-actin antibody; gamma-enteric smooth muscle antibody; Smooth muscle gamma actin antibody; Smooth muscle gamma-actin antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Actin, gamma-enteric smooth muscle protein (181-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，ACTG2 Antibody (CSB-PA12799A0Rb)，的標記方式是Non-conjugated。對于ACTG2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA12799B0Rb ACTG2 Antibody, HRP conjugated ELISA
    FITC CSB-PA12799C0Rb ACTG2 Antibody, FITC conjugated
    Biotin CSB-PA12799D0Rb ACTG2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能參考文獻：
    1. fetus with intestinal pseudo-obstruction heterozygous for p.R63G pathogenic variant (NM_001615.3 c.187C>G; rs864309491) in exon 3 PMID: 29072330
    2. Whole exome and Sanger sequencing revealed a pathogenic variant in the ACTG2 gene in 4 out of 28 probands with chronic intestinal pseudo-obstruction and megacystis. Moreover, a mutational hotspot in the ACTG2 gene was recognized. Genetic heterogeneity is evident. PMID: 28422808
    3. R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the intestinal and bladder smooth muscle filaments. PMID: 27007401
    4. ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner. PMID: 28385530
    5. Missense variants in ACTG2 were identified in the patients with either megacystis-microcolon-intestinal hypoperistalsis syndrome or intestinal pseudo-obstruction. PMID: 26813947
    6. A heterozygous missense variant in ACTG2 was identified that impaired actin polymerization in sporadic Megacystis microcolon intestinal hypoperistalsis syndrome. PMID: 26647307
    7. ACTG2 is expressed in a fraction of small intestinal neuroendocrine tumors, can inhibit cell growth in vitro, and is positively regulated by miR-145. PMID: 27107594
    8. Mutations within ACTG2 are associated with fetal megacystis in microcolon intestinal hypoperistalsis syndrome. PMID: 25998219
    9. Phenotypic spectrum of ACTG2 missense variants involved severe pathology in multiple smooth muscle-dependent organs including the biliary tract and the uterus in the family with visceral myopathy. PMID: 25782675
    10. gammaSMA expression in hepatocellular carcinoma is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells PMID: 26110787
    11. ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease. PMID: 24676022
    12. Two novel mutations in the ACTG2 gene, p.R178L and p.R178C, have been identified in two unrelated children with congenital distended bladder, microcolon, and intestinal hypoperistalsis (MMIHS). PMID: 24337657
    13. The R148S variant in ACTG2 as a cause of autosomal dominant familial visceral myopathy in one family. PMID: 22960657
    14. NOX4 and ROS have a role in myofibroblast differentiation and collagen and alpha-actin production of TGF- beta1-induced nasal polyp-derived fibroblasts. PMID: 22722757
    15. SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
    16. It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. PMID: 17009076
    17. TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. PMID: 17554369
    18. The insertion-deletion polymorphism in intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. PMID: 17934296
    19. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053

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  • 相關(guān)疾?。?/div>
    Visceral myopathy (VSCM)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Actin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 145

    OMIM: 102545

    KEGG: hsa:72

    STRING: 9606.ENSP00000295137

    UniGene: Hs.516105