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ADAMTS18 Antibody

  • 中文名稱：
    ADAMTS18兔多克隆抗體
  • 貨號：
    CSB-PA493628
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western blot analysis of 3T3 using ADAMTS-18 antibody.. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ADAMTS18 antibody; ADAMTS21A disintegrin and metalloproteinase with thrombospondin motifs 18 antibody; ADAM-TS 18 antibody; ADAM-TS18 antibody; ADAMTS-18 antibody; EC 3.4.24.- antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ADAMTS-18. at AA rangle: 1030-1110
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT and NF-kappaB signaling, further suppressing EMT and metastasis of breast cancer cells. PMID: 28503860
    2. This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) PMID: 28814085
    3. Studies suggest that ADAM metallopeptidase with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target. PMID: 24896365
    4. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers PMID: 24874986
    5. Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia. PMID: 23818446
    6. study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases PMID: 23356391
    7. the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation. PMID: 21862674
    8. ADAMTS18 mutations promote growth, migration, and metastasis in melanoma PMID: 21047771
    9. ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis. PMID: 19806480
    10. Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas. PMID: 17546048
    11. ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. PMID: 19249006

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  • 相關疾病：
    Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17110

    OMIM: 607512

    KEGG: hsa:170692

    STRING: 9606.ENSP00000282849

    UniGene: Hs.188746