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ADPGK Antibody

  • 中文名稱：
    ADPGK兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001380GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ADPGK
  • 別名：
    2610017G09Rik antibody; ADP dependent glucokinase antibody; ADP GK antibody; ADP-dependent glucokinase antibody; ADP-GK antibody; ADPGK antibody; ADPGK_HUMAN antibody; ATP dependent glucokinase antibody; DKFZP434B195 antibody; RbBP 35 antibody; RbBP-35 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ADPGK
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
  • 基因功能參考文獻(xiàn)：
    1. ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose PMID: 26555263
    2. ADPGK can contribute to tumour cell survival under conditions of high glycolytic dependence. PMID: 23799003
    3. human ADPGK(ADP-dependent glucokinase) catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated. PMID: 22219026
    4. Glucose and insulin response to oral glucose is higher in GCK(261) carriers, indicating clinical heterogeneity in GCK maturity diabetes carriers. PMID: 19903754
    5. The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of glucokinase, particularly if there is a positive family history. PMID: 19309449

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    ADP-dependent glucokinase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25250

    OMIM: 611861

    KEGG: hsa:83440

    STRING: 9606.ENSP00000312250

    UniGene: Hs.562587