ADRA2B Antibody
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中文名稱(chēng):ADRA2B兔多克隆抗體
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貨號(hào):CSB-PA585658
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規(guī)格:¥2024
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱(chēng):Rabbit anti-Homo sapiens (Human) ADRA2B Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:ADRA2B; ADRA2L1; ADRA2RL1; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2BAR
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Synthesized peptide derived from internal of Human Adrenergic Receptor alpha-2B.
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免疫原種屬:Homo sapiens (Human)
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克隆類(lèi)型:Polyclonal
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,IF
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推薦稀釋比:
Application Recommended Dilution IF 1:100-1:500 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
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基因功能參考文獻(xiàn):
- An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion). PMID: 28482761
- Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression. PMID: 28923554
- full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. PMID: 27901063
- The ADRA2B DD genotype was associated with Hypertension and was more common in the native population of Mountain Shoria (Siberia). PMID: 29039833
- stress administered immediately before learning selectively enhanced long-term recall in ADRA2B deletion carriers. Stress administered 30min before learning impaired recognition memory in male deletion carriers, while enhancing recognition memory in female deletion carriers. PMID: 28254464
- This study demonstrated that a deletion variant of the ADRA2B gene encoding the alpha2b-adrenoceptor reduces the stress-induced shift from hippocampal cognitive toward dorsal striatal habit memory. PMID: 28115477
- These results identify a beta2-adrenergic-Ca(2+)-actin axis as a new regulator of cell deformability. PMID: 27875276
- ADRA2B SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids. PMID: 28456594
- These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers. PMID: 26899992
- role of GGA3 in the cell surface export of alpha2B-adrenergic receptor PMID: 26811329
- Common polymorphisms in the ADRA2B gene are not associated with orthostatic hypotension risk in Chinese. PMID: 26427149
- norepinephrine-related neurogenetic differences enhance the subjective vividness of perceptual experience and its emotional enhancement. PMID: 25904801
- The results of this study suggested that ADRA2B is closely related to the individual difference in human attention orientation, but not to the individual difference in emotional processing. PMID: 25325286
- ADRA2B deletion carriers showed decreased neural activity in the amygdala when recognizing emotional faces in control condition and increased amygdala activity under stress. PMID: 25127926
- The ADRA2B deletion variant may selectively predict stress effects on memory in females. PMID: 24997351
- Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block. PMID: 25558682
- Carrying the ADRA2B deletion variant enhances the relationship between arousal at encoding and subsequent memory for moderately arousing events. PMID: 24149058
- ADRA2B mutations are associated with emotional subjectivity of viusal perception. PMID: 24058067
- The ADRA2b deletion variant, which was previously associated with vasoconstriction, to emotional memory and visual perception. PMID: 24269973
- A mutation in alpha2B-adrenergic receptor is associated with autosomal dominant cortical myoclonus and epilepsy. PMID: 24114805
- Carriers of the ADRA2B functional deletion variant showed an impaired recognition and slower retrieval of neutral faces under stress. PMID: 23583499
- Statistically significant prevalence of homozygous genotype DD of ADRA2B gene was found in patients with atrioventricular blocks and sick sinus node syndrome. PMID: 24087960
- this study demonstrated for the first time an independent contribution of the ADRA2B genetic polymorphism to memory impairment and we further suggest a possible protective role of the deletion variant against the disease development. PMID: 23499426
- Adenosine alpha2B receptor is upregulated in the peripheral blood leukocytes of multiple sclerosis patients. PMID: 23225885
- Molecular dynamics simulations of palmitoylated/glycosylated, membrane-integrated human A(2B)AR in its native environment is a possible approach and this model can be used for designing potent and selective A(2B)AR antagonists. PMID: 22570080
- There were no main effects or interactions in relation to ADRA2B genotype. PMID: 21965191
- The significant novel finding from this study is that the affective modulation of T2 detection is influenced by a non-additive (epistatic) interaction between the ADRA2B and 5-HTTLPR insertion/deletion polymorphisms. PMID: 21854681
- Adenosine A(2B) receptor signaling plays a role in regulating placental 11beta-hydroxysteroid dehydrogenase type 2 expression, and consequently fetal development. PMID: 22701600
- Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content. PMID: 22743060
- A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export PMID: 22404651
- For the first time, we revealed on clinical - genetic material association between hereditary disturbances of cardiac conduction and polymorphism of 2-adrenergic receptor gene. PMID: 22839581
- this study found significant effects of ADRA2B haplotype polymorphisms on response inhibition in a large Chinese sample, with the minor AAGG haplotype associated with shorter SSR. PMID: 22218095
- Data strongly demonstrate that the small GTPase ARF1 modulates ERK1/2 activation by alpha(2B)-AR and provide the first evidence indicating a novel function for ARF1 in regulating the MAPK signaling pathway. PMID: 22025613
- the ADRA2B polymorphism influences emotional memory formation but not memory retrieval in the amygdala and left inferior frontal gyrus. PMID: 21259387
- The noradrenaline-mediated depolarization of vascular smooth muscle cells is produced by activation of both alpha(1)-and alpha(2)-adrenoceptors. PMID: 20739228
- Was detected polymorphisms of ADRA2B in patients with atrial fibrillation. PMID: 21942960
- ADRA2B gene polymorphism might be associated with the hereditary sick sinus node syndrome. PMID: 21878072
- Data do not show any association between the presence of the alpha2B-adrenergic receptor deletion allele and the occurrence of spontaneous abortions. PMID: 21159032
- Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface PMID: 21357695
- gene x exercise interactions were observed for A2BGlu9/12 and B2Gln27Glu on change in lean soft tissue (LST, p = 0.02); exercisers on the A2BGlu9- background gained LST compared to a loss among controls over 12 months (p\0.05) PMID: 20401689
- Homozygote for insertion [I]/deletion allele of alpha(2B)-AR gene polymorphism is associated with silent myocardial ischemia in type 2 diabetes mellitus patients with coronary artery disease. PMID: 20692245
- the findings of this study do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects. PMID: 20651814
- Data provide strong evidence indicating that Rab8 GTPase interacts with distinct motifs in the C termini of alpha(2B)-AR and beta(2)-AR and differentially modulates their traffic from the TGN to the cell surface. PMID: 20424170
- carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val158 carriers compared to met158 carriers. PMID: 20110158
- The ADRA2B 301-303 deletion allele (ins/del and del/del, n = 18) was associated with resistance to desensitization. PMID: 20051907
- Middle-aged white men carrying the DD genotype of the alpha(2B)-AR have a significantly increased risk for sudden cardiac death and myocardial infarction, especially before the age of 55 years. PMID: 12535806
- No major functional significance of the alpha(2B) adrenergic receptor polymorphism in the present sample of morbidly obese subjects was found. PMID: 12822042
- A polymorphism in the (alpha)2B adrenoceptor gene associates with hypertension. PMID: 14744925
- body fat response to exercise training in older adults is associated with the combined effects of the Glu12/Glu9 alpha2b-adrenergic receptor, Trp64Arg beta3-adrenergic receptor, and Gln27Glu beta2-adrenergic receptor gene variants PMID: 15166301
- The 12Glu9 polymorphism of ADRA2B is associated with impaired insulin secretion and may predict the development of Type 2 diabetes. PMID: 15309292
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相關(guān)疾?。?/div>Epilepsy, familial adult myoclonic, 2 (FAME2)亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.蛋白家族:G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2B sub-subfamily數(shù)據(jù)庫(kù)鏈接:
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