ADRB3 Antibody
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中文名稱:ADRB3兔多克隆抗體
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貨號(hào):CSB-PA120361
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規(guī)格:¥1100
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:ADRB3; ADRB3R; B3AR; Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Synthetic peptide of Human ADRB3
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:Antigen affinity purification
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,IHC
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推薦稀釋比:
Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:15-1:50 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
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基因功能參考文獻(xiàn):
- results of this study have shown a significant association between the Trp64Arg polymorphism in ADRB3 gene and the development of overweight and obesity in Saudi populations; It also has an influence on the levels of lipid, insulin, leptin, and glucose PMID: 29587766
- the association between the Arg64 allele of the Trp64Arg polymorphism of ADRB3 gene, FATMAX, and LDL-cholesterol levels should be interpreted with caution, as it may represent a small portion of complex physiological processes related to lipolysis and metabolism lipids. PMID: 28941386
- Nerve fibers expressing immunoreactivity for beta3AR were abundantly found in the mucosa and muscular layers of the human bladder. PMID: 28185314
- The presence of the Trp64Trp genotype is related to higher TAG level in CTDs and reliably predicts hypertriglyceridemia. PMID: 29606859
- The current meta-analysis demonstrated that Trp64Arg polymorphism in ADRB3 was associated with sus- ceptibility to GDM in the European Caucasian population. PMID: 28783993
- The mechanism(s) of downstream beta3 adrenoceptor activation in human corpus cavernosum and in penile artery involves CSE-derived H2S and cGMP elevation. In other words, beta3 relaxation does not need the endothelium but is still able to amplify the cGMP signaling through H2S pathway. This study defines a possible novel pharmacological approach in erectile dysfunction treatment. PMID: 28760490
- There were no differences between the distribution of genotypes and the allele frequencies of the PPARG Pro12Ala, and C1431T polymorphisms and the ADRB3 Trp64Arg polymorphism in normo- and hyperglycaemic women. PMID: 29464546
- the mechanism of beta3-AR-mediated upregulation of hepatic apoA-I expression PMID: 28802864
- ADRB3 gene Trp64Arg mutation was significantly associated with an increased predisposition toward hypertension and elevated systolic/diastolic BP in hypertensive patients, suggesting that Trp64Arg is an important hypertension-susceptibility marker. PMID: 28404887
- Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
- Middle-age adult Asians with the ADRB3 rs4994 minor alleles are at increased risk of Type 2 Diabetes (Meta-Analysis). PMID: 28521197
- It has been shown, that presence of one mutant allele of rs9939609 (gene FTO) and rs4994 (gene ADRB3) leads to statistically significant association with obesity. PMID: 29381017
- In mutant group of beta3 adrenoreceptor gene patients have higher insulin and HOMA levels than wild type group, without relation with metabolic PMID: 28421794
- Pharmacological experiments allowed us to demonstrate that these effects were driven by an Erk1/2-mediated activation of the antioxidant transcription factor PPARg. These results suggest that b3-AR protective effects in the myometrium could be due to its dual antioxidant properties. PMID: 28723418
- body mass index (BMI) >/=25, PRRs of beta-3 adrenergic receptor genotype (Trp/Arg and Arg/Arg) for periodontal disease markers were 0.13 to 0.70, those of PPARgamma genotype (Pro/Pro) were 0.66 to 3.14 and those of the interaction term for the two genotypes were 1.69 to 12.61. Results confirm a positive relation between beta-3 adrenergic receptor genotype & PPAR-gamma genotype PMID: 25855572
- Study reports association of the Arg64 allele of the rs4994 polymorphism of ADRB3 with increased serum urate in Western Polynesian individuals. PMID: 26410617
- ADRB3 expression correlated strongly with overactive bladder related symptoms. PMID: 26617941
- our result suggested complex interactions amongst the studied SNPs and ADRB3 rs4994 as candidate influencing GBC susceptibility. PMID: 26602921
- A non-significant association between total body fat (TBF) and B3Trp64Arg persisted among sedentary controls only when intervention groups were separated (%TBF gain with B3Arg64+ carriage, p = 0.03); exercisers lost TBF regardless of genotype. PMID: 20401689
- Study tested the association of peroxisome proliferator-activated receptor and beta3-AR polymorphisms with metabolic, nutritional, and blood pressure parameters in 271 postmenopausal women PMID: 25827163
- Trp64Arg polymorphism associated with elevated lipid and apolipoprotein levels in Chinese population PMID: 25928572
- W64R Polymorphism in the adrenergic beta-3- receptor is not associated with obesity and waist-to-hip ratio. PMID: 25800470
- Meta-analysis: Trp64Arg polymorphism in the beta3-AR gene is involved in the pathogenesis of overactive bladder. PMID: 25867395
- Carriers of the ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers. PMID: 25081806
- Genetic association of ADRB3 single nucleotide polymorphism with metabolic syndrome among the Tatars PMID: 26410938
- Arg64 associated with decreased response to reactive hyperemia in the brachial artery PMID: 24670327
- in the codominant model Trp/Arg genotype, there was an odds ratio or 1.67 which was increased to 2.56 for the Arg/Arg genotype for association with type 2 diabetes PMID: 24972470
- No significant differences in lipolysis or lipid oxidation were observed between 64R and 64W allele carriers of ADRB3 at any time during the aerobic load. PMID: 24905907
- T190C variation of the beta3-AR gene was not associated with increased risk for chronic heart failure PMID: 25636111
- Aromatic residues in adrenergic beta-3 receptor play an important role in the function of the receptor. PMID: 22728712
- genetic polymorphism determines relationship between childhood obesity and asthma in Taiwan PMID: 24786241
- Higher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism. PMID: 24658877
- results demonstrate that the activation of beta3-adrenoceptors inhibits neurogenic contractions ofboth rat and human urinary bladder. PMID: 24378642
- study indicates a positive association between periodontal disease and the beta-3 adrenergic receptor genotype in obese individuals. PMID: 24460850
- This study shows that the Trp64Arg polymorphism in the beta3-AR gene is weakly but significantly associated with overactive bladder syndrome PMID: 24038238
- Results suggest that epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications. PMID: 24579945
- UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients PMID: 24138564
- The results of these studies suggest that genetic variants of the FTO gene rs9939609 genotype and Trp64Arg ADRB3 contribute to the development of obesity among residents of Moscow and Sverdlovsk Region of Russia. PMID: 25059067
- Suggest that ADRB3 C190T may be involved in the complex pathophysiology of coronary artery disease. PMID: 24201118
- Genetic polymorphisms of ADRB3, FTO, and UCP2 genes are associated with overweight in athletes of winter sports. PMID: 24741957
- beta3-ARs are expressed in B16F10 melanoma cells. beta3-ARs are involved in B16F10 cell proliferation and apoptosis. Reduced beta3-AR function decreases the growth of melanoma induced by B16F10 cell inoculation PMID: 23907236
- Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia PMID: 23729572
- ADRb3 T190C polymorphism is significantly associated with Gallbladder cancer and gallstone disease susceptibility. PMID: 24556804
- Human ureteral relaxation is mediated by both beta(2) - and beta(3) -adrenoceptor stimulation. beta(3) -Adrenoceptor agonists have the potential to relax the human ureter, and their clinical application in the treatment of ureteral stones is expected. PMID: 23360304
- Enhanced expression of beta3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase. PMID: 24190960
- The study signifies that the Arg64 allele of the ADRB3 gene is a genotypic risk factor and confers susceptibility to type 2 diabetes PMID: 23968135
- beta3AR 64 Trp/Arg substitution accelerates age-related decrease in BAT activity, and thereby may associate with visceral fat accumulation with age. PMID: 23032405
- In a study population of young adult Japanese males, the impact of the Trp64Arg polymorphism on the association between exercise and body composition was weak, if it existed at all. PMID: 23292548
- study found disease risk factors in postmenopausal women are not directly associated with the polymorphisms of peroxisome proliferator-activated receptor gamma 2 and adrenoceptor beta 3 genes PMID: 23113754
- Trp64Arg variant of ADRB3 was associated with body mass index in East Asians, but not Europeans PMID: 21358132
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB3 sub-subfamily
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組織特異性:Expressed mainly in adipose tissues.
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