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AFG1L Antibody, Biotin conjugated

  • 中文名稱：
    AFG1L兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA819895LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AFG1L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AFG1L
  • 別名：
    AFG1 antibody; ATPase family gene 1 homolog antibody; CG8520 gene product antibody; lace1 antibody; LACE1_HUMAN antibody; Lactation elevated protein 1 antibody; Lactivation elevated 1 antibody; Protein AFG1 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human AFG1-like ATPase protein (14-313AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
  • 基因功能參考文獻：
    1. Increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis. PMID: 27323408
    2. This study establishes LACE1 as a novel factor with a crucial role in mitochondrial protein homeostasis. PMID: 26759378
    3. association between bipolar disorder and two SNPs in the gene LACE1 PMID: 20872768
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    8. Observational study of genetic testing. (HuGE Navigator) PMID: 18237552

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  • 亞細(xì)胞定位：
    Mitochondrion membrane.
  • 蛋白家族：
    AFG1 ATPase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16411

    OMIM: 617469

    KEGG: hsa:246269

    STRING: 9606.ENSP00000357973

    UniGene: Hs.259666