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AIFM3 Antibody

  • 中文名稱：
    AIFM3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA444394
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA444394(AIFM3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA444394(AIFM3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: CSB-PA444394(AIFM3 Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    AIFM3
  • 別名：
    AIFL antibody; Aifm3 antibody; AIFM3_HUMAN antibody; Apoptosis inducing factor 3 antibody; Apoptosis inducing factor like antibody; Apoptosis inducing factor like protein antibody; Apoptosis inducing factor; mitochondrion associated antibody; Apoptosis-inducing factor 3 antibody; Apoptosis-inducing factor-like protein antibody; FLJ30473 antibody; FLJ45137 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human AIFM3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
  • 基因功能參考文獻(xiàn)：
    1. Upregulated expression of AIFM3 is associated with cholangiocarcinoma. PMID: 27473083
    2. The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age. PMID: 22550867
    3. AIFM3 is a direct target of miR-210 in human hepatoma cells. PMID: 22387901
    4. AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain. PMID: 15764604
    5. AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function. PMID: 16001080
    6. H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events PMID: 19166416

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  • 亞細(xì)胞定位：
    Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis.
  • 蛋白家族：
    FAD-dependent oxidoreductase family
  • 組織特異性：
    Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26398

    OMIM: 617298

    KEGG: hsa:150209

    STRING: 9606.ENSP00000382120

    UniGene: Hs.723246