ALDH1B1 Antibody
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中文名稱(chēng):ALDH1B1兔多克隆抗體
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貨號(hào):CSB-PA000860
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:ALDH1B1
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別名:Acetaldehyde dehydrogenase 5 antibody; AL1B1_HUMAN antibody; Aldehyde dehydrogenase 1 family; member B1 antibody; Aldehyde dehydrogenase 1B1 antibody; Aldehyde dehydrogenase 5 antibody; Aldehyde dehydrogenase family 1 member B1 antibody; Aldehyde dehydrogenase X antibody; Aldehyde dehydrogenase X mitochondrial antibody; ALDH class 2 antibody; Aldh1b1 antibody; ALDH5 antibody; ALDHX antibody; MGC2230 antibody; Mitochondrial aldehyde dehydrogenase X antibody; mitochondrial antibody; OTTHUMP00000021399 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Monkey
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免疫原:Synthesized peptide derived from the Internal region of Human ALDH1B1.
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:WB, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
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基因功能參考文獻(xiàn):
- These results suggest that ALDH1B1 is a novel human colorectal cancer biomarker PMID: 28881356
- The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. PMID: 28594837
- ALDH1B1 is expressed at very high levels in human pancreatic cancer, and it contributes to proliferation in these tumor cells. PMID: 26566217
- High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. PMID: 26366059
- Data show that ALDH1B1 may promote colon cancer tumorigenesis by modulating the Wnt/beta-catenin, Notch and PI3K/Akt signaling pathways. PMID: 25950950
- ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. PMID: 25413692
- ALDH1B1 SNPs play a role in shaping the alcohol drinking patterns among the Inuit in Greenland. PMID: 25311581
- ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
- ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer. PMID: 21216231
- An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin PMID: 20955166
- a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity. PMID: 20205700
- ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample PMID: 18782342
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亞細(xì)胞定位:Mitochondrion matrix.
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蛋白家族:Aldehyde dehydrogenase family
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組織特異性:Liver, testis and to a lesser extent in brain.
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數(shù)據(jù)庫(kù)鏈接:
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