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AMBP Antibody

  • 中文名稱：
    AMBP兔多克隆抗體
  • 貨號：
    CSB-PA001654YA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, U251 whole cell lysate
      All lanes: AMBP antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 39 kDa
    • IHC image of CSB-PA001654YA01HU diluted at 1:150 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AMBP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AMBP
  • 別名：
    A1M antibody; Alpha 1 microglobulin/bikunin precursor antibody; Alpha 1 microglycoprotein antibody; Alpha-1 microglycoprotein antibody; Alpha-1-microglobulin antibody; AMBP antibody; AMBP_HUMAN antibody; Bikunin antibody; Complex-forming glycoprotein heterogeneous in charge antibody; EDC1 antibody; Growth inhibiting protein 19 antibody; HCP antibody; HI-30 antibody; HI30 antibody; IATIL antibody; ITI antibody; ITI-LC antibody; ITIL antibody; Microglobulin (alpha 1) antibody; Protein AMBP antibody; Protein HC antibody; Trypstatin antibody; Uristatin antibody; Uronic-acid-rich protein antibody; UTI antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein AMBP protein (20-203AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，AMBP Antibody (CSB-PA001654YA01HU)，的標(biāo)記方式是Non-conjugated。對于AMBP Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA001654YB01HU AMBP Antibody, HRP conjugated ELISA
    FITC CSB-PA001654YC01HU AMBP Antibody, FITC conjugated
    Biotin CSB-PA001654YD01HU AMBP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.; Trypstatin is a trypsin inhibitor.
  • 基因功能參考文獻(xiàn)：
    1. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia. PMID: 27155336
    2. Prophylactic UTI maintains the endothelial barrier function, increases VE-cadherin expression, and inhibits the phosphorylation of VE-cadherin at Tyr658 under inflammatory conditions PMID: 26681130
    3. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. PMID: 26728454
    4. Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin. PMID: 26497278
    5. results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse PMID: 25555815
    6. Proximal tubular dysfunction, indicated by urine alpha1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women. PMID: 25370597
    7. placental alpha microglobulin-1 is a sensitive and specific test to assess rupture of membranes in patients with an equivocal diagnosis based on simple tests PMID: 24698819
    8. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. PMID: 25561734
    9. Decreased bikunin mRNA level in renal cells might be associated with poor prognosis of renal carcinoma. PMID: 24980765
    10. The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue. PMID: 23642167
    11. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN. PMID: 24211404
    12. The high level of serum AMBP could predict the poor response of the AGC patients. PMID: 24135868
    13. In pre-term pregnant women with intact membranes, placental alpha-microglobulin-1 in cervicovaginal fluid test rates are more positive in cases of uterine contraction. PMID: 23919851
    14. our findings suggest that urine bikunin level, as well as proteinuria, could represent a useful parameter for monitoring renal function in those patients that do not present any symptoms of renal insufficiency. PMID: 23841057
    15. Determined is the first structure of human alpha-1-microglobulin with heavy electron density of the chromophore. PMID: 24012674
    16. Sulfation of the bikunin chondroitin sulfate chain determines heavy chain.hyaluronan complex formation PMID: 23801333
    17. High urine alpha-1-microglobulin is associated with interstitial fibrosis and tubular atrophy plus inflammation. PMID: 23414180
    18. High urine alpha-1-microglobulin is associated with ischemic acute tubular necrosis than other causes of acute kidney injury. PMID: 23324582
    19. Report prognostic value of urinary alpha 1-macroglobulin in idiopathic membranous nephropathy. PMID: 22595828
    20. crystal of alpha1-microglobulin belonged to space group P4(3), with unit-cell parameters a = b = 36.45, c = 112.68 A PMID: 22684072
    21. The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding. PMID: 22096585
    22. urinary marker for the differential diagnosis of Balkan endemic nephropathy PMID: 21332340
    23. These findings suggest that there was no significant association in genotype distribution of Init-2 polymorphism of the AMBP gene between patients with kidney stones and healthy controls. PMID: 20602574
    24. the cell-protective effects of alpha(1)-microglobulin during alpha-particle irradiation PMID: 20954860
    25. The promoter of AMBP gene had polymorphisms at positions -218 and -189 nt giving three different genotypes with no association between these observed genotypes and kidney stone-forming phenotypes. PMID: 20602574
    26. increased protein levels in preeclamptic women PMID: 19879940
    27. significant relationship was established between the low level and absence of bikunin, and pro-u-PA in urine samples from patients with bladder tumors; identified bikunin loss in urine as a potential bladder carcinoma marker PMID: 19914646
    28. Transfection into H460M Human large cell lung carcinoma line decreased tumor growth and metastasis in nude mice PMID: 11807786
    29. Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. PMID: 11877257
    30. bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells PMID: 14597629
    31. Data show that alpha(1) -microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. PMID: 15037615
    32. alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores PMID: 15452109
    33. Bikunin neither decreased expression of TGF-beta receptors (TbetaRI and TbetaRII) in cancer cells nor altered the specific binding of 125I TGF-beta1 to the cells. PMID: 15498571
    34. The TSG-6 and inter-alpha-inhibitor interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link. PMID: 15653696
    35. the second processed protein from AMBP, bikunin, strongly interacted with the full-length hepatitis E virus ORF3 protein PMID: 16140784
    36. the ORF3 protein exploits the endosomal sorting machinery to enhance the secretion of an immunosuppressant molecule (alpha1 microglobulin) from cultured hepatocytes PMID: 16407257
    37. Identification of the protein bikunin as an endogenous, competitive inhibitor of a dynorphin-converting enzyme in human cerebrospinal fluid. PMID: 17087727
    38. Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. PMID: 17115277
    39. Bikunin was found to localize on the cell membrane, while tryptase was in the secretary granules of the mast cells from psoriatic lesions. PMID: 17146627
    40. alpha(1)-microglobulin participates in the defense against oxidation by hemoglobin, heme, and reactive oxygen species PMID: 17320766
    41. small angle X-ray scanning study of the monomer and dimer forms of alpha1-microglobulin; monomer is characterised by a radius of gyration R(G)= 2.20 nm and D(max)=6.3 nm and the dimer by R(G)=2.99 nm and D(max)=9.5 nm PMID: 17584166
    42. The ability of alpha-1-microglobulin to restore the initial conformation characteristic for the native protein and the internal dynamics after the unfolding of the globule by 10 M urea and 6 M guanidine hydrochloride has been ascertained. PMID: 17633530
    43. AMBP has radical scavenging activity. PMID: 17766242
    44. urinary trypsin inhibitor is insufficiently produced for neutrophil elastase release after cardiac arrest PMID: 17998887
    45. in multiple myeloma patients without renal failure, elevated Alpha-1-microglobulin excretion might be an early marker of renal tubular involvement PMID: 18046670
    46. In the present study, structural motifs regulating bikunin's anti-inflammatory function are delineated. Binding of bikunin to neutrophils is critically important for its anti-inflammatory capacity. PMID: 18226914
    47. The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. PMID: 18448433
    48. Overexpression of bikunin reduced the gene expression of matriptase, which attenuated in vitro cell invasion in prostate cancer. PMID: 18649735
    49. Overexpression of Urinary trypsin inhibitor is associated with recurrence in hepatocellular carcinoma. PMID: 19636634

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 453

    OMIM: 176870

    KEGG: hsa:259

    STRING: 9606.ENSP00000265132

    UniGene: Hs.436911