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AMIGO2 Antibody, HRP conjugated

  • 中文名稱：
    AMIGO2兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA769765LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AMIGO2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AMIGO2
  • 別名：
    Adhesion molecule with Ig like domain 2 antibody; ALI 1 antibody; ALI1 antibody; Alivin 1 antibody; Alivin-1 antibody; Alivin1 antibody; AMGO2_HUMAN antibody; AMIGO 2 antibody; AMIGO-2 antibody; Amigo2 antibody; Amphoterin induced gene 2 antibody; Amphoterin induced protein 2 antibody; Amphoterin-induced gene and open reading frame 2 antibody; Amphoterin-induced protein 2 antibody; DEGA antibody; Differentially expressed in gastric adenocarcinoma antibody; Differentially expressed in gastric adenocarcinomas antibody; Transmembrane protein AMIGO 2 antibody; Transmembrane protein AMIGO2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Amphoterin-induced protein 2 protein (420-522AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
  • 基因功能參考文獻：
    1. Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. PMID: 28272394
    2. this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. PMID: 29149598
    3. AMIGO2 is an important regulator of the PDK1-Akt pathway. PMID: 26553931
    4. Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. PMID: 12843293
    5. Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice. PMID: 15107827

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    Immunoglobulin superfamily, AMIGO family
  • 組織特異性：
    Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24073

    OMIM: 615690

    KEGG: hsa:347902

    STRING: 9606.ENSP00000266581

    UniGene: Hs.121520