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AMPD2 Antibody

  • 中文名稱：
    AMPD2兔多克隆抗體
  • 貨號：
    CSB-PA211918
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells, NIH-3T3 cells and COLO205 cells, using AMPD2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AMPD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AMPD2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human AMPD2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
  • 基因功能參考文獻(xiàn)：
    1. Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
    2. tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
    3. In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
    4. Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
    5. N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092

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  • 相關(guān)疾病：
    Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
  • 組織特異性：
    Highly expressed in cerebellum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 469

    OMIM: 102771

    KEGG: hsa:271

    STRING: 9606.ENSP00000256578

    UniGene: Hs.82927