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ANAPC11 Antibody

  • 中文名稱：
    ANAPC11兔多克隆抗體
  • 貨號：
    CSB-PA001696GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ANAPC 11 antibody; ANAPC11 antibody; Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody; Anaphase promoting complex subunit 11 antibody; Anaphase promoting complex subunit 11 homolog (yeast) antibody; Anaphase promoting complex subunit 11 homolog antibody; Anaphase-promoting complex subunit 11 antibody; Apc 11 antibody; Apc 11p antibody; APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody; APC11 anaphase promoting complex subunit 11 homolog antibody; APC11 antibody; APC11_HUMAN antibody; Apc11p antibody; Cyclosome subunit 11 antibody; Hepatocellular carcinoma associated RING finger protein antibody; Hepatocellular carcinoma-associated RING finger protein antibody; HSPC 214 antibody; HSPC214 antibody; MGC882 antibody; Yeast APC 11 homolog antibody; Yeast APC11 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ANAPC11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
  • 基因功能參考文獻：
    1. siRNA targeted against Apc11 could hamper entry into G2/M phase. PMID: 23007976
    2. Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress PMID: 15256223
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    RING-box family
  • 組織特異性：
    Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14452

    OMIM: 614534

    KEGG: hsa:51529

    UniGene: Hs.534456