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ARFRP1 Antibody

  • 中文名稱：
    ARFRP1兔多克隆抗體
  • 貨號：
    CSB-PA133087
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA133087(ARFRP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA133087(ARFRP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 293T cells, human fetal liver tissue, human cervical cancer tissue, Human fetal muscle tissue, Primary antibody: CSB-PA133087(ARFRP1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ARFRP1
  • 別名：
    ADP ribosylation factor related protein 1 antibody; ADP-ribosylation factor-related protein 1 antibody; ARF related protein 1 antibody; ARF related protein antibody; ARF-related protein 1 antibody; ARFRP_HUMAN antibody; ARFRP1 antibody; ARL 18 antibody; ARL18 antibody; ARP 1 antibody; ARP antibody; ARP1 antibody; Helicase like protein NHL antibody; MGC6837 antibody; SCG10 like protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ARFRP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
  • 基因功能參考文獻：
    1. Results provide evidence that ARFRP1 is required for HCV propagation through its interaction with NS5A protein. Also, ARFRP1 is involved in the regulation of lipid droplet (LD) growth in HCV-infected cells and, recruits SNAP23 to sites in close proximity to LDs. PMID: 27550144
    2. ARFRP1 shifted from a predominantly cis-Golgi and endosome-to-trans-Golgi network localization to localizing both Golgi and non-Golgi vesicular structures in hNaa30-depleted cells. PMID: 28356483
    3. One or more of 7 genes residing in a chromosome 20q13.3 CNV region appears to influence BMI. The strongest candidate is ARFRP1. PMID: 26881067
    4. Propose that Arfrp1 exposes a binding site on AP-1 that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell. PMID: 23326640
    5. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. PMID: 22505585
    6. Data show that ADP-ribosylation factor-related protein 1 (ARFRP1) is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of golgin-97 and golgin-245 onto Golgi membranes. PMID: 16129887
    7. These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi. PMID: 17127620
    8. Results show that ARL1 and ARFRP1 regulate retrograde transport of Shiga toxin to the TGN and anterograde transport of VSVG from the TGN, respectively. PMID: 19224922

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  • 亞細胞定位：
    Golgi apparatus. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 組織特異性：
    Found in most tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 662

    OMIM: 604699

    KEGG: hsa:10139

    STRING: 9606.ENSP00000326884

    UniGene: Hs.389277