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ARHGEF10 Antibody

  • 中文名稱：
    ARHGEF10兔多克隆抗體
  • 貨號：
    CSB-PA176345
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA176345(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA176345(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ARHGEF10
  • 別名：
    ARHGA_HUMAN antibody; ARHGEF10 antibody; DKFZp686H0726 antibody; GEF10 antibody; KIAA0294 antibody; MGC131664 antibody; Rho guanine nucleotide exchange factor (GEF) 10 antibody; Rho guanine nucleotide exchange factor 10 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ARHGEF10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in developmental myelination of peripheral nerves.
  • 基因功能參考文獻：
    1. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
    2. This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population. PMID: 27934548
    3. A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found. PMID: 26143528
    4. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). PMID: 21719701
    5. the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population PMID: 21743172
    6. The functional single-nucleotide polymorphism of ARHGEF10 confers the susceptibility to atherothrombotic stroke. PMID: 20042462
    7. data support a role for ARHGEF10 in developmental myelination of peripheral nerves PMID: 14508709
    8. Gef10 is the third member of a Rho-specific GEF family with unusual protein architecture PMID: 16896804
    9. A novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. PMID: 19635168

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  • 相關疾?。?/div>
    Slowed nerve conduction velocity (SNCV)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14103

    OMIM: 608136

    KEGG: hsa:9639

    STRING: 9606.ENSP00000340297

    UniGene: Hs.98594