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ARPIN Antibody

  • 中文名稱(chēng)：
    ARPIN兔多克隆抗體
  • 貨號(hào)：
    CSB-PA773801LA01HU
  • 規(guī)格：
    ￥440
  • 促銷(xiāo)：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25, 44 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA773801LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773801LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) ARPIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARPIN
  • 別名：
    2610034B18Rik antibody; Actin related protein 2/3 complex inhibitor antibody; Arp2/3 inhibition protein antibody; ARPIN antibody; C15orf38 antibody; Chromosome 15 open reading frame 38 antibody; CO038_HUMAN antibody; Hypothetical protein LOC348110 antibody; MGC61550 antibody; RIKEN cDNA 2610034B18 antibody; UPF0552 protein C15orf38 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Arpin protein (1-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，ARPIN Antibody (CSB-PA773801LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于A(yíng)RPIN Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA773801LB01HU ARPIN Antibody, HRP conjugated ELISA
    FITC CSB-PA773801LC01HU ARPIN Antibody, FITC conjugated
    Biotin CSB-PA773801LD01HU ARPIN Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
  • 基因功能參考文獻(xiàn)：
    1. ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling. PMID: 28531800
    2. Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients PMID: 28293092
    3. Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins. PMID: 26774128
    4. Arpin downregulation may contribute to the initiation and development of breast cancer metastasis. PMID: 26648569
    5. Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis. PMID: 25892881

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  • 亞細(xì)胞定位：
    Cell projection, lamellipodium.
  • 蛋白家族：
    Arpin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 28782

    OMIM: 615543

    KEGG: hsa:348110

    STRING: 9606.ENSP00000350075

    UniGene: Hs.6734