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ATG4D Antibody

  • 中文名稱：
    ATG4D兔多克隆抗體
  • 貨號：
    CSB-PA070059
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    9830134P12Rik antibody; APG4 autophagy 4 homolog D antibody; APG4 D antibody; APG4; S. cerevisiae; homolog of; D antibody; APG4D antibody; ATG4 autophagy related 4 homolog D (S. cerevisiae) antibody; Atg4d antibody; ATG4D_HUMAN antibody; Atg4dl antibody; AUT like 4 cysteine endopeptidase antibody; AUT-like 4 cysteine endopeptidase antibody; AUTL4 antibody; Autophagin 4 antibody; Autophagin-4 antibody; autophagy 4; S. cerevisiae; homolog of; D antibody; autophagy related 4D; cysteine peptidase antibody; Autophagy related cysteine endopeptidase 4 antibody; Autophagy related protein 4 homolog D antibody; Autophagy-related cysteine endopeptidase 4 antibody; Autophagy-related protein 4 homolog D antibody; Cysteine protease ATG4D antibody; Cysteine protease involved in autophagy antibody; MGC31226 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Atg4D.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.; Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
  • 基因功能參考文獻：
    1. study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells PMID: 28834690
    2. The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts. PMID: 23508006
    3. the import of Atg4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, reactive oxygen species, mitophagy and cell viability. PMID: 22441018
    4. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. PMID: 19549685
  • 亞細胞定位：
    [Cysteine protease ATG4D]: Cytoplasm.; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix.
  • 蛋白家族：
    Peptidase C54 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20789

    OMIM: 611340

    KEGG: hsa:84971

    STRING: 9606.ENSP00000311318

    UniGene: Hs.512799