AXIN1 Antibody
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中文名稱:AXIN1兔多克隆抗體
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貨號:CSB-PA517675LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) AXIN1 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:AI316800 antibody; AXIN antibody; Axin 1 antibody; Axin-1 antibody; axin1 antibody; AXIN1_HUMAN antibody; Axis inhibition protein 1 antibody; Axis Inhibitor 1 antibody; Fu antibody; fused antibody; Fused; mouse; homolog of antibody; hAxin antibody; Kb antibody; Ki antibody; kinky antibody; knobbly antibody; MGC132911 antibody; MGC52315 antibody; PPP1R49 antibody; Protein Fused antibody; Protein phosphatase 1 regulatory subunit 49 antibody
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宿主:Rabbit
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反應種屬:Human
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免疫原:Recombinant Human Axin-1 protein (418-707AA)
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
本頁面中的產(chǎn)品,AXIN1 Antibody (CSB-PA517675LA01HU),的標記方式是Non-conjugated。對于AXIN1 Antibody,我們還提供其他標記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關產(chǎn)品
靶點詳情
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功能:Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation.
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基因功能參考文獻:
- RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling. PMID: 29932918
- TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway. PMID: 28754688
- coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth. PMID: 28731177
- data delineate opposing roles for gamma-Pcdh isoforms in regulating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-Pcdh-C3 isoform PMID: 27530555
- Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population. PMID: 29053018
- Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. PMID: 28100566
- role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells PMID: 28107521
- RUNX1 and AXIN1 proteins are strongly correlated in ER(-) tumors as well. PMID: 28055379
- Mutagenesis and binding studies using the bivalent TNKS binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS ankyrin repeat conformations modulated by Axin1 interaction. PMID: 27594684
- LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/ beta-catenin pathway in the pathogenesis of colorectal cancer PMID: 26894286
- The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma. PMID: 26968103
- AXIN1 is expressed in meningioma along with APC and E-cadherin PMID: 27630299
- Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
- Cancer point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth in vivo through a gain-of-function mechanism. PMID: 26974125
- The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells. PMID: 27138857
- Data show that 5-hydroxytryptamine receptor (5-HT1DR) played an important role in cell invasion via Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway. PMID: 26214021
- GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction. PMID: 26393419
- We have offered primary evidence that the T allele and T/T genotype of rs370681 polymorphisms and C/T genotype of rs1805105 polymorphisms in AXIN1 gene are more frequent in patients with cryptorchidism. PMID: 25802106
- Higher expression of AXIN1 protein in IUGR placentae indicates a role of Wnt/beta-catenin signaling pathway in pathology of placental development. PMID: 24846767
- This study study showed that HMGA2 was able to elicit EMT and regulate several genes which are closely related to the Wnt/beta-catenin pathway by directly binding to their promoter. PMID: 23135750
- Significantly increased atrial septal defect risk was observed to be associated with the A allele of rs12921862 PMID: 25355064
- suggest a novel mechanism of Wnt signaling through the dissociation of the beta-catenin destruction complex by Axin1 Thr160 modification PMID: 25735981
- In adenomatous polyposis coli, beta-catenin phosphorylation involves Axin and the 20 amino acids of APC or APCL. PMID: 24722208
- Which destabilize beta-catenin through stabilizing Axin. PMID: 24419084
- Gastric neoplasia of chief cell-predominant type (GN-CCP) as a unique variant of nonaggressive tumor are characterized by nuclear beta-catenin accumulation and mutation of CTNNB1 or AXIN gene, suggesting activation of the Wnt/beta-catenin pathway. PMID: 24011952
- The expression levels of CTNNB1, AXIN1 and APC did not correlate with the beta-catenin mutation status, which corroborates previous gene expression micro-array analyses PMID: 23525311
- methylation status of the Axin gene may be one important factor to predict radiosensitivity of lung cancer. PMID: 23915259
- In invasive breast cancer preserved Axin expression is associated with a more aggressive phenotype and reduced survival. PMID: 23278310
- Our study revealed that alterations of AXIN1 were involved in hepatitis B virus-related hepatocellular carcinoma PMID: 23879168
- X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells PMID: 23110995
- Abnormal hypermethylation of Axin gene is associated with lung cancer. PMID: 23192643
- HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling. PMID: 23277359
- Despite the absence of AXIN1 gene mutations, the low level of Axin-1 protein in the cytoplasm probably also plays a role in tumorigenesis. PMID: 21769465
- Phosphorylation of axin-1 by glycogen synthase kinase(GSK)-3beta accelerates the association of axin-1 with beta-catenin. PMID: 22933777
- respiratory epithelial polygonal and cuboidal cells have distinct expression of beta-catenin, Axin, and C-myc PMID: 22614067
- Low axin1 is associated with hepatocellular carcinoma. PMID: 22524844
- Results demonstrate that beta-catenin is not only phosphorylated inside the APC/Axin1 destruction complex, but also ubiquinated and degraded via the proteasome, all within an intact Axin1 complex. PMID: 22682247
- 3 synonymous alterations (p.P39P, p.D260D, p.V383V)were found in patients with ALL and one novel synonymous alteration (p.G67G) in the cohort with AML. A new g.G42525A variation was seen in intron 4-5 in 3 patients with acute leukemia. PMID: 21902576
- Wnt/beta-catenin signaling and AXIN1 may regulate the efficacy of inhibitors of BRAF(V600E), suggesting that manipulation of the Wnt/beta-catenin pathway could be combined with BRAF inhibitors to treat melanoma PMID: 22234612
- These results reveal an important mode of Myc activation in human breast cancer and a mechanism contributing to Myc deregulation involving unique insight into inactivation of the Axin1 tumor suppressor in breast cancer. PMID: 21808024
- RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins PMID: 21799911
- Axin I expression was investigated in 42 patients with glioblastoma, the most aggressive form of glial tumors. Immunostaining and image analysis revealed the quantity and localization of the protein. PMID: 21648318
- methylation of Axin by PRMT1 may serve as a finely tuned regulation mechanism for Wnt/beta-catenin signaling. PMID: 21242974
- axin associates with ubiquitin-specific protease 34 (USP34); results indicate USP34 controls the levels of axin and positively modulate Wnt signaling by acting downstream of beta-catenin stabilization through controlling the nuclear accumulation of axin PMID: 21383061
- found that dominant-negative mutants of PML blocked AXIN-induced p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions PMID: 21057547
- these results support a model in which the unfolded nature of these critical scaffolding regions in Axin1 facilitates dynamic interactions with a kinase and its substrate, which in turn act upon each other. PMID: 21087614
- Study demonstrate that the DIX domains of Dvl and Axin are expressed noticeably in a multi-cistronic system but not in a mono-cistronic system. PMID: 20846493
- Down regulation of axin expression and up regulation of beta-catenin were detected in neuroepithelial brain tumors PMID: 19633924
- MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway PMID: 20128690
- Axin downregulates TCF-4 transcription via beta-catenin and independently of p53. PMID: 20122174
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相關疾病:Hepatocellular carcinoma (HCC); Caudal duplication anomaly (CADUA)
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亞細胞定位:Cytoplasm. Nucleus. Membrane. Cell membrane.
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組織特異性:Ubiquitously expressed.
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