Birc5 Antibody
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中文名稱:Birc5兔多克隆抗體
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貨號:CSB-PA002706HA01MO
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Mus musculus (Mouse) Birc5 Polyclonal antibody
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Uniprot No.:
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基因名:Birc5
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別名:Birc5 antibody; Api4 antibody; Iap4Baculoviral IAP repeat-containing protein 5 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; TIAP antibody
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宿主:Rabbit
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反應(yīng)種屬:Mouse, Human
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免疫原:Recombinant Mouse Baculoviral IAP repeat-containing protein 5 protein (1-140AA)
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免疫原種屬:Mus musculus (Mouse)
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標記方式:Non-conjugated
本頁面中的產(chǎn)品,Birc5 Antibody (CSB-PA002706HA01MO),的標記方式是Non-conjugated。對于Birc5 Antibody,我們還提供其他標記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function.
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基因功能參考文獻:
- The present results indicated that PPARgamma may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma regulation during cerebral ischemia. PMID: 29039513
- While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation. PMID: 27427516
- HDL-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. PMID: 28038379
- Survivin also attenuates DNA damage related to PARP activation and inhibits TNFalpha-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli. PMID: 28055005
- The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin. PMID: 27678504
- this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin PMID: 27440860
- Survivin was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation PMID: 27715398
- SurvivinT34A combined with arsenic trioxide induces a loss of mitochondria membrane potential PMID: 27748945
- Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche. PMID: 26832409
- TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function. PMID: 26418219
- Survivin is a key gene for regulating squamous cell carcinoma (SCC) cancer stem cell formation and cancer SCC development. PMID: 26771605
- In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 and ki67. PMID: 26722528
- survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation. PMID: 26810226
- Survivin directly participates in PRL-mediated beta cell proliferation via Akt, STAT5-PIM and ERK signalling pathways during pregnancy PMID: 26099856
- Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model. PMID: 25678789
- Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury PMID: 25987205
- NR4A1 protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP expression. PMID: 26157144
- Studies indicate the importance of survivin in Sonic hedgehog (SHH)-driven medulloblastoma (MB). PMID: 25241898
- the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin PMID: 25778398
- Both HIF1-alpha and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy. PMID: 25400763
- survivin-mediated radio-adaptive response is dependent upon the ability of cells to activate NFkappaB PMID: 25763931
- These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis. PMID: 25204429
- Survivin has an important role in regulating folliculogenesis and oogenesis in the adult mouse ovary. PMID: 24675472
- Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets PMID: 24903482
- The study shows that the inhibition of survivin is sufficient to reduce joint inflammation and bone damage in preclinical models of arthritis PMID: 25381389
- Survivin haploinsufficiency in syngeneic grafts was associated with Ischemia/reperfusion tissue injury, which triggered inflammation eventually resulting in graft loss. PMID: 24731002
- UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5. PMID: 24818710
- Findings support the importance of adhesion molecules (VE-cadherin and CD31), survivin, and Ajuba in modulating the Hippo pathway, which regulates, in part, proliferation and survival in hemangioendotheliomas. PMID: 25266662
- Survivin may be an essential mediator of cyto-protection in podocytes injury. PMID: 24747598
- The survivin cascade in neural progenitor cells plays a role in anti-apoptosis. PMID: 24022164
- Data suggest that toll-like receptor 3 (TLR3), phosphatidylinositol 3-kinase (PI3K), survivin, Fas ligand (FasL), and CD95 (Fas) genes are involved in the development of cervical cancer. PMID: 25106857
- A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression. PMID: 24793696
- Data indicate that loss of survivin in conditional Pten deletion mouse model delays prostate tumor progression. PMID: 23936028
- The present studies aim to examine whether and how cilia function (Pkd1 or Pkd2) and structure (Tg737) play a role in cystic kidney and aneurysm through survivin downregulation. PMID: 24235270
- Increased expression of survivin correlates with the proliferation of neural stem cells in the DG of the hippocampus soon after traumatic brain injury. PMID: 23900556
- STAT3 phosphorylation and subsequent upregulation of survivin expression mediated by Notch-2 signaling in renal proximal tubule epithelial cells aid in the functional and structural recovery of the kidney from acute kidney injury. PMID: 23949800
- sticky siRNAs against survivin and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 tumors as well as formation and dissemination of melanoma lung metastases. PMID: 23835136
- Data suggest survivin is a key mediator of cytoprotection in acute lung injury (as seen in antineoplastic-induced pulmonary fibrosis); survivin appears to act at epithelial/mucosal cell level; survivin action depends partly on apoptosis inhibition. PMID: 23979427
- Data from Pak1 knockout mice and RNA interference in cells suggest Pak1 has role in regulation of survivin ubiquitination/stability in beta-cells; impaired proliferation of beta-cells induced by loss of PAK1 is restored by overexpression of survivin. PMID: 23514967
- survivin inhibition/down-regulation with flavopiridol or specific shRNAs increased the apoptotic response of old fibroblasts to various genotoxic agents PMID: 22252435
- These results suggest that OX40 costimulation crucially engages survivin during antigen-mediated Th2 responses PMID: 23616302
- Thimerosal induces S phase arrest and finally causes apoptosis via inhibition of PI3K/Akt/survivin signaling. PMID: 23145070
- vaccination with recombinant Fowlpox expressing survivin improves T-cell responses against aggressive Malignant mesothelioma tumors and may form the basis for promising clinical applications. PMID: 23335100
- Our data support a function of survivin in hippocampal synaptic plasticity and learning and underline the importance of adult brain neurogenesis for proper operation of the hippocampal tri-synaptic circuit and the physiological functions that depend on it PMID: 23123921
- This study identified a novel role for survivin in erythroblast enucleation through previously unknown protein partners. PMID: 22491741
- overexpression of Bmi1 induces repressive epigenetic regulation of the promoter of Survivin, a well-characterized antiapoptotic protein. PMID: 23132836
- prepared two mutant forms of the PhSurv-PhTERT tandem with two or four Sp1 sites removed from the distal "long" PhSurv promoter PMID: 23056318
- Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. PMID: 22638909
- these data suggest a potentially novel role for survivin in functionally promoting astrocytic proliferation after intracerebral hemorrhage PMID: 22862734
- Survivin is a dual regulator of lens epithelial cell proliferation and lens fiber cell differentiation. PMID: 23213276
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亞細胞定位:Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody.
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蛋白家族:IAP family
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