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C2CD3 Antibody

  • 中文名稱：
    C2CD3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA673367LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA673367LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA673367LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA673367LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) C2CD3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    C2CD3
  • 別名：
    C2CD3 antibody; C2 domain-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human C2 domain-containing protein 3 protein (2079-2265AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，C2CD3 Antibody (CSB-PA673367LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于C2CD3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA673367LB01HU C2CD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA673367LC01HU C2CD3 Antibody, FITC conjugated
    Biotin CSB-PA673367LD01HU C2CD3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
  • 基因功能參考文獻(xiàn)：
    1. Our data provide further evidence that mutations in C2CD3 cause a ciliopathy in humans and expand the previously reported phenotype resulting from C2CD3 dysfunction. PMID: 27094867
    2. we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD) syndrome PMID: 25412110
    3. Loss of C2CD3 results in short centrioles without subdistal and distal appendages. PMID: 24997988
  • 相關(guān)疾病：
    Orofaciodigital syndrome 14 (OFD14)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24564

    OMIM: 615944

    KEGG: hsa:26005

    STRING: 9606.ENSP00000323339

    UniGene: Hs.557938