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CABLES1 Antibody

  • 中文名稱：
    CABLES1兔多克隆抗體
  • 貨號：
    CSB-PA138718
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from LOVO cells, using Ik3-1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CABLES1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CABLES1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human Ik3-1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.
  • 基因功能參考文獻(xiàn)：
    1. We have identified four potentially pathogenic missense CABLES1 variants as a novel, although infrequent, cause of Cushing's Disease in children and young adults. PMID: 28533356
    2. miR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit(+) cell proliferation and apoptosis. PMID: 28583208
    3. Cables1/p21 pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 is probably one of several downstream effector molecules to mediate Cables1. PMID: 28118639
    4. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease PMID: 26695862
    5. the results suggest Cables1 as a novel p21 regulator through maintaining p21 stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21. PMID: 24975575
    6. Results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1. PMID: 25361894
    7. The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism. PMID: 21890215
    8. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing. PMID: 16177568
    9. Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation. PMID: 17982127
    10. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported. PMID: 18059193

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Cyclin family
  • 組織特異性：
    Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25097

    OMIM: 609194

    KEGG: hsa:91768

    STRING: 9606.ENSP00000256925

    UniGene: Hs.11108